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ANTXR1


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Symbol:ANTXR1
Name(s):anthrax toxin receptor 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:ATR, FLJ10601, FLJ11298, FLJ21776, TEM8
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15689409 This is the first demonstration that the ATR/TEM8 protein is highly expressed in epithelial cells, suggesting that the ATR/TEM8 expression pattern is highly relevant for understanding the pathogenesis of anthrax infection.
16401723 Data show that cells expressing palmitoylation-defective mutant receptors are less sensitive to anthrax toxin due to a lower number of surface receptors as well as premature internalization of protective antigen without a requirement for heptamerization.
11700562 Here we describe the cloning of the human PA receptor using a genetic complementation approach
15777794 results indicate that TEM8 plays a positive role in endothelial cell activities related to angiogenesis
16141341 because protective antigen binds to CMG2 with much higher affinity than it does to TEM8, a lower pH is needed to attenuate CMG2 binding to allow pore formation; toxin can form pores at different points in the endocytic pathway
16762926 TEM8 is a new adhesion molecule linking collagen I or PA to the actin cytoskeleton
15689409 ATR/TEM8 protein is highly expressed in epithelial cells, which represent the primary location for bacterial invasion.
15993844 These results suggest that the TEM-8 vW and transmembrane domains may play an important biological role in TEM-8 related tubule formation.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBCLXtumor endothelial marker 8 isoform 1 precursor--Pubmed
HPRDBCL2-like 1 isoform 1Tumor endothelial marker 8--Pubmed
HPRDHistone deacetylase 2tumor endothelial marker 8 isoform 1 precursor--Pubmed
HPRDhistone deacetylase 2Tumor endothelial marker 8--Pubmed

ANTXR1 results (if any) from reagent suppliers

Google CSE Logo
ANTXR1 antibody, Rabbit A' Anthrax Toxin Recep. Antibody, Rabbit ...
Buy quality rabbit ANTXR1 antibody (interacts with n/a), anti-ANTXR1, Rabbit A' Anthrax Toxin Recep. antibody, rabbit polyclonal antibody, Rabbit A' Anthrax ...
http://www.genwaybio.com/product_info.php?products_id=245142...

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ANTXR1 Antibody (Y382)
Formalin-fixed and paraffin-embedded human lung carcinoma tissue reacted with ANTXR1 Antibody (Y382) (Cat.#AP7746a), which was peroxidase-conjugated to the
...
http://www.abgent.com/products/catalog_no/AP7746a_ANTXR1_Ant...

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Peptide-affinity Purified Polyclonal Antibody to Tumor Endothelial ...
... anthrax toxin receptor; tumor endothelial marker 8, isoform 3 precursor Official Gene Symbol - ANTXR1 GenBank Accession Number – NP_115584 LocusLink ID
...
http://www.imgenex.com/antibody_details.php?catalog=IMG-3076...

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Phospho-ANTXR1-pY382 Antibody
Dot blot analysis of anti-Phospho-ANTXR1-pY382 Antibody (Cat.#AP3547a) on nitrocellulose membrane. 50ng of Phospho-peptide or Non Phospho-peptide per dot
...
http://www.abgent.com/products/catalog_no/AP3547a_Phospho_AN...

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TEM8 (H-140) Antibody sc-15406
Human, ANTXR1, 84168, 2p14, NM_018153, NM_032208, NM_053034 · Q9H6X2 · 606410. Mouse, Antxr1, 69538, 6 D1, Q9CZ52, N/A. Ordering Information ...
http://www.scbt.com/datasheet-15406-tem8-h-140-antibody.html...

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Abgent - Phosphospecific Antibody
AP3468aNEW, Phospho-AKT3-S472 Antibody, DB, E, WB†, H. AP3547a, Phospho-ANTXR1- pY382 Antibody, DB, E, H. AP3603aNEW, Phospho-ANTXR1-pY425 Antibody, DB, E, H
...
http://www.abgent.com/products/category/phosphospecific...

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TEM8 siRNA (m) sc-40201
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Antxr1, 69538, 6 D1, Q9CZ52 ...
http://www.scbt.com/datasheet-40201-atr-tem8-sirna-m.html...

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