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SORBS2


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Symbol:SORBS2
Name(s):sorbin and SH3 domain containing 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:ARGBP2, KIAA0777, PRO0618
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15949647 The sorbin N- and C-termini were localized in the human ArgBP2 gene locus; they are spliced to the 5' and 3' ends of the 95% homologous region; thus, a revised human sorbin nucleotide sequence is proposed.
12475393 complexation with Cbl mediates ubiquitination and degradation of c-Abl
15784622 ArgBP2gamma is a physiological substrate of Akt, functions as an adaptor for Akt and PAK1, and plays a role in Akt/PAK1 cell survival pathway
12510380 regulates cytoskeletal organization and signal transduction--review

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDv-abl Abelson murine leukemia viral oncogene homolog 1 isoform asorbin and SH3 domain containing 2 isoform 2--Pubmed
HPRDv-abl Abelson murine leukemia viral oncogene homolog 1 isoform asorbin and SH3 domain containing 2 isoform 2--Pubmed
HPRDTyrosine protein kinase ABL2sorbin and SH3 domain containing 2 isoform 2--Pubmed
HPRDv-abl Abelson murine leukemia viral oncogene homolog 2 isoform bArg binding protein 2--Pubmed
BINDCas-Br-M ecotropic retroviral transforming sequenceHomo sapiens Arg/Abl-interacting protein ArgBP2a mRNA, complete cds.ArgBP2-A interacts with Cbl.-Pubmed
BINDCas-Br-M ecotropic retroviral transforming sequenceHomo sapiens Arg/Abl-interacting protein ArgBP2a mRNA, complete cds.ArgBP2 interacts with Cbl.-Pubmed
HPRDPTK2B protein tyrosine kinase 2 beta isoform asorbin and SH3 domain containing 2 isoform 2--Pubmed
HPRDPTK2B protein tyrosine kinase 2 beta isoform asorbin and SH3 domain containing 2 isoform 2--Pubmed
BINDPTK2B protein tyrosine kinase 2 beta isoform aHomo sapiens Arg/Abl-interacting protein ArgBP2a mRNA, complete cds.ArgBP2 interacts with Pyk2.-Pubmed
HPRDAF6sorbin and SH3 domain containing 2 isoform 2--Pubmed

Recent Publications on SORBS2:

Pubmed Logo
Copy Number and Gene Expression Alterations in Radiation-Induced Papillary Thyroid Carcinoma from Chernobyl Pediatric Patients.
Background: Following exposure to radiation during the Chernobyl fallout...
4th September, 2009
1 Roswell Park Cancer Institute , Department of Cancer Genetics, Buffalo, Thyroid. 2009 Sep 2.
DOI Direct Link
ArgBP2 and the SoHo family of adapter proteins in oncogenic diseases.
ArgBP2, a member of the SoHo family of adapter proteins, is a regulator of...
2nd September, 2009
INSERM U, Parc Scientifique et Technologique de Luminy, Marseille, France. Cell Adh Migr. 2009 Apr;3(2):167-70. Epub 2009 Apr 5.
ArgBP2-dependent signaling regulates pancreatic cell migration, adhesion, and tumorigenicity.
The poor prognosis of pancreatic cancer is due to rapid locoregional...
19th August, 2008
INSERM U.624, Marseille cedex 9, France. Cancer Res. 2008 Jun 15;68(12):4588-96.
DOI Direct Link
ArgBP2, encoding a negative regulator of ABL, is fused to MLL in a case of infant M5 acute myeloid leukemia involving 4q35 and 11q23.
Integrative genomic and gene-expression analyses have identified amplified...
27th September, 2007
Leukemia. 2006 Jul;20(7):1310-3. Epub 2006 Apr 20.
DOI Direct Link
Homozygous deletions localize novel tumor suppressor genes in B-cell lymphomas.
Integrative genomic and gene-expression analyses have identified amplified...
21st February, 2007
Center for Applied Medical Research (CIMA), University of Navarra, Avda Blood. 2007 Jan 1;109(1):271-80. Epub 2006 Sep 7.
DOI Direct Link

View more research publications.

SORBS2 results (if any) from reagent suppliers

Google CSE Logo
ArgBP2 siRNA (m) sc-141193
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. マウス, Sorbs2, 234214, 8 B1.1, Q3UTJ2 ...
http://www.scbt.com/ja/datasheet-141193-argbp2-sirna-m.html...

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Abcam antibodies and reagents product map
... SH2D4A antibodies (2) · SH3BP5 antibodies (1) · SIRPß1/CD172b antibodies (1 ) · SORBS2 antibodies (1) · STK35 antibodies (2) · Styk1 antibodies (4) ...
http://www.abcam.com/index.html?cl=2105&pageconfig=productma...

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ArgBP2 siRNA (h) sc-40336
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, SORBS2, 8470, 4q35.1, NM_003603, ...
http://www.scbt.com/ko/datasheet-40336-argbp2-sirna-h.html...

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ArgBP2 (H-15) Antibody sc-14134
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, SORBS2, 8470, 4q35.1, NM_003603, ...
http://www.scbt.com/ja/datasheet-14134-argbp2-h-15-antibody....

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