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ORAI1
| Symbol: | ORAI1 | | Name(s): | ORAI calcium release-activated calcium modulator 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CRACM1, FLJ14466, ORAT1, TMEM142A | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18250319 |
results imply a positive feedback loop in which an initial TCR signal favors up-regulation of STIM1 and Orai proteins that would augment Ca2+ signaling during subsequent antigen encounter |
| 17968026 |
analysis of how Orai1 mutations alter ion permeation and Ca2+-dependent fast inactivation of CRAC channels |
| 17442569 |
CRACM1, CRACM2, and CRACM3 are store-operated Ca2+ channels with distinct functional properties. |
| 17702753 |
the interacting domains of STIM1 and Orai1 have roles in Ca2+ release-activated Ca2+ channel activation |
| 17684017 |
analysis of the plasma membrane-endoplasmic reticulum contact sites reveals the presence of additional molecular components within the STIM1-Orai1 Complex |
| 17452328 |
Results suggest that Orai1, -2, and -3 channels are similarly inhibited by extracellular calcium, indicating similar affinities for Ca(2+) within the selectivity filter. |
| 17218358 |
Ca2+ entry supporting [Ca2+]i oscillations in HEK293 cells depends upon the Ca2+ sensor, Stim1, and calcium release-activated Ca2+ channel protein, Orai1 |
| 16766533 |
suppression of store-operated channels function by Orai1 overexpression likely reflects a required stoichiometry between STIM1 and Orai1 |
| 17224452 |
dynamic assembly of TRPC1-STIM1-Orai1 ternary complex is involved in activation of SOC channel in response to internal Ca2+ store depletion |
| 16733527 |
STIM1 and CRACM1 interact functionally. Overexpression of both proteins greatly potentiates I(CRAC), suggesting that STIM1 and CRACM1 mutually limit store-operated currents and that CRACM1 may be the long-sought CRAC channel. | →View more information from publications. |
Recent Publications on ORAI1: |  |
R93W mutation in Orai1 causes impaired calcium influx in platelets.
The intracellular Ca(2+) concentration of non-excitable cells is regulated... | 28th October, 2008
| Immune Disease Institute and Harvard Medical School, Boston, MA, United
| Blood. 2008 Oct 24.
DOI Direct Link |
Calcium influx mechanisms underlying calcium oscillations in rat hepatocytes.
The process of capacitative or store-operated Ca(2+) entry has been... | 28th October, 2008
| Laboratory of Signal Transduction, National Institute of Environmental
| Hepatology. 2008 Oct;48(4):1273-81.
DOI Direct Link |
Stim1 and Orai1 Mediate CRAC Currents and Store-Operated Calcium Entry Important for Endothelial Cell Proliferation.
Recent breakthroughs in the store-operated calcium (Ca(2+)) entry (SOCE)... | 11th October, 2008
| Cardiovascular Sciences, Albany Medical College, Albany, NY 12208, USA.
| Circ Res. 2008 Oct 9.
DOI Direct Link |
Role of lipid rafts in the interaction between hTRPC1, Orai1 and STIM1.
Store-operated Ca(2+) entry (SOCE) is a mechanism regulated by the filling... | 10th October, 2008
| Department of Physiology, Cellular Physiology Research Group, University
| Channels (Austin). 2008 Nov 23;2(6).
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Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation.
Platelet activation and aggregation at sites of vascular injury is... | 4th October, 2008
| Rudolf Virchow Center, DFG Research Center for Experimental Biomedicine,
| Blood. 2008 Oct 2.
DOI Direct Link |
→View more research publications. |
ORAI1 results (if any) from reagent suppliers | 
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ORAI1 Antibody (NT) a T cell calcium channel
ORAI1 antibody can be used for detection of ORAI1 by Western blot at 0.5 – 1 ug/ ml.,
http://www.prosci-inc.com/shop/catalog1/ORAI1-Antibody-p-647...
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Orai1 antibody (ab59330) datasheet | Abcam
Rabbit polyclonal to Orai1. Orai1 is a pore subunit of the Ca 2+ release- activated Ca 2+ channel. It is responsible for store-operated Ca 2+ influx,...
http://www.abcam.com/index.html?datasheet=59330...
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ORAI1 Antibody
Rabbit polyclonal ORAI1 antibody was raised against an 18. amino acid peptide from near the ... ORAI1 antibody is supplied as immunoaffinity purified IgG in
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http://www.prosci-inc.com/shop/pdf/4041.pdf...
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O8264 Anti ORAI1 antibody produced in rabbit ~1.0 mg/mL, affinity ...
O8264 Anti-ORAI1 antibody produced in rabbit ~1.0 mg/mL, affinity isolated antibody, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...
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Orai1 (D90B10) Rabbit mAb #3280
Orai1 (D90B10) Rabbit mAb detects endogenous levels of total Orai1 protein. The antibody also cross-reacts with an unidentified protein at 78 kDa. ...
http://www.cellsignal.com/products/3280.html...
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ORAI1 Peptide (NT) ORAI1 peptide
ORAI1 peptide is used for blocking the activity of ORAI1 antibody. It usually blocks the antibody activity completely in Western blot by incubating the ...
http://www.prosci-inc.com/shop/catalog1/ORAI1-Peptide-p-2046...
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Anti-Human Orai1 (extracellular)
Alomone Labs is pleased to offer a new antibody raised against an extracellular epitope of the human Orai1 channel, Anti-Orai1(extracellular) antibody. ...
http://www.alomone.com/p_postcards/database/421.htm...
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ORAI Detection Set ORAI1, ORAI2, ORAI3, STIM1, and STIM2
A missense mutation in the ORAI1 protein in humans is the cause of one form of hereditary severe combined immune deficiency (SCID) which results in ablated ...
http://www.prosci-inc.com/shop/catalog1/ORAI-Detection-Set-p...
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Orai1 siRNA (m) sc-76002
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; RT-PCR Primer also available: Orai1 ...
http://www.scbt.com/datasheet-76002-orai1-sirna-m.html...
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Anti-Human Orai1 (extracellular)-FITC
Alomone Labs is pleased to offer a new version of the Anti-Human Orai1 ( extracellular) antibody (#ACC-060) directly conjugated to FITC. The Anti-Human
Orai1 ...
http://www.alomone.com/p_postcards/database/451.htm...
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