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YARS
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18096501 |
Mutating a conserved tyrosine (Y341) that tethers a critical ELR motif in TyrRS resulted in subtle opening of the structure, and activation of cytokine functions, proving the possibility of constitutive gain-of-function mutations in tRNA ligases. |
| 12416978 |
The recently discovered proangiogenic role of a tyrosyl-tRNA synthetase fragment that stimulates immune cells and links translation to a major cell-signaling pathway is discussed in this review. |
| 11927599 |
replacement of second lysine in KMSKS signature sequence by potassium |
| 16429158 |
identification of two heterozygous missense mutations (G41R and E196K) and one de novo deletion (153-156delVKQV) in tyrosyl-tRNA synthetase (YARS) in three unrelated families affected with dominant intermediate Charcot-Marie-Tooth neuropathy |
| 12016229 |
the KMSSS sequence in human tyrosyl-tRNA synthetase stabilizes the transition state for the tyrosine activation reaction by interacting with the pyrophosphate moiety of ATP |
| 11956181 |
role in inducing angiogenesis |
| 15779907 |
The gene for mitochondrial tyrosyl-tRNA synthetase is described and the initial characterization of the enzyme is reported. Genes for the remaining missing synthetases have also been found with the exception of human glutaminyl-tRNA synthetase. |
| 15840810 |
first example of a TyrRS lacking specificity toward N1-N72 and thus of a TyrRS disobeying the identity rules |
| 11856731 |
role in catalyzing tyrosyl-adenylate formation |
| 12427973 |
The structure of human mini-TyrRS containing both the catalytic & the anticodon recognition domains, is reported to a resolution of 1.18 A. The spatial disposition of the anticodon recognition domain relative to the catalytic domain is unique. | →View more information from publications. |
Recent Publications on YARS: |  |
Dominant mutations in the tyrosyl-tRNA synthetase gene recapitulate in Drosophila features of human Charcot-Marie-Tooth neuropathy.
Dominant-intermediate Charcot-Marie-Tooth neuropathy (DI-CMT) is... | 10th September, 2009
| Laboratory of Developmental Genetics, Center for Human Genetics,
| Proc Natl Acad Sci U S A. 2009 Jul 14;106(28):11782-7. Epub 2009 Jun 26.
DOI Direct Link |
Mediastinal lipoblastoma causing diaphragmatic eventration: a case report and review of the literature.
Lipoblastomatous tumors are quite rare neoplasms derived from embryonic... | 30th May, 2009
| Department of Pediatrics, Faculty of Medicine, Karadeniz Technical
| J Pediatr Hematol Oncol. 2009 May;31(5):346-8.
DOI Direct Link |
Global gene expression profiling of ischemic preconditioning in the rat retina.
PURPOSE: To obtain and analyze the gene expression changes after ischemic... | 5th September, 2007
| Department of Ophthalmogenetics, Netherlands Institute for Neuroscience,
| Mol Vis. 2007 Jun 28;13:1020-30.
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[Detection of arterial hypertension in school childrens]
INTRODUCTION: Hypertension is a multifactorial desease, with increasingly... | 7th March, 2007
| Escuela de Medicina, Universidad Nacional del Comahue Cipolletti, Rio
| Rev Fac Cien Med Univ Nac Cordoba. 2005;62(3):47-52.
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Functional analyses of glycyl-tRNA synthetase mutations suggest a key role for tRNA-charging enzymes in peripheral axons.
Charcot-Marie-Tooth disease type 2D (CMT2D) and distal spinal muscular... | 10th November, 2006
| Genome Technology Branch, National Human Genome Research Institute,
| J Neurosci. 2006 Oct 11;26(41):10397-406.
DOI Direct Link |
→View more research publications. |
YARS results (if any) from reagent suppliers | 
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TyrRS (N-16) Antibody sc-26207
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, YARS, 8565, 1p35.1, NM_003680 ...
http://www.scbt.com/datasheet-26207-tyrrs-n-16-antibody.html...
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Abgent - Metabolism Antibodies - Metabolism
AP7580b, Tyrosyl tRNA synthetase (YARS) Antibody (C-term), WB, IHC, E, H. AP7580a, Tyrosyl tRNA synthetase (YARS) Antibody (N-term), WB, E, H ...
http://www.abgent.com/products/category/cell_function/metabo...
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TyrRS (m3): 293T Lysate sc-126172
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Yars, 107271, 4 D2.2, Q91WQ3 ...
http://www.scbt.com/datasheet-126172-tyrrs-m3-293t-lysate.ht...
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Induction of CHOP Expression by Amino Acid Limitation Requires ...
tagaactcctctgcggtggt-3), YARS (forward primer, 5-gatcggaaggaggatgt- gaa-3; reverse primer, ..... and YARS mRNA inducibility is strongly decreased but not
...
http://www.eurogentec.com/egt/files/AveroustJBC2795288siRNA....
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TyrRS (h): 293 Lysate sc-113365
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, YARS, 8565, 1p35.1, P54577 ...
http://www.scbt.com/datasheet-113365-tyrrs-h-293-lysate.html...
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