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RUNX1
| Symbol: | RUNX1 | | Name(s): | runt-related transcription factor 1 (acute myeloid leukemia 1; aml1 oncogene) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AML1, AML1-EVI-1, AMLCR1, CBFA2, EVI-1, PEBP2aB | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18328148 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17989718 |
constitutively and overexpressed AML1-ETO protein was cleaved to four fragments of 70, 49, 40 and 25 kDa by activated caspase-3 during apoptosis induction by extrinsic mitochondrial and death receptor signaling pathways. |
| 18003885 |
cdk phosphorylation of RUNX1 potentially couples stem/progenitor proliferation and lineage progression |
| 18206538 |
RUNX1 over-representation is associated to a poor outcome of acute lymphoblastic leukemia. |
| 18206548 |
RUNX1 rearrangements in acute myeloblastic leukemia relapsing after hematopoietic stem cell transplantation. |
| 17910630 |
RUNX1 mutation is associated with poor prognosis in patients with primary myelodysplastic syndrome. It may play a role in the development and progression of a subset of primary myelodysplastic syndrome |
| 15654961 |
Observational study of gene-disease association. (HuGE Navigator) |
| 15968309 |
Observational study of genetic testing. (HuGE Navigator) |
| 16249223 |
Observational study of gene-disease association. (HuGE Navigator) |
| 16519819 |
Observational study of gene-disease association. (HuGE Navigator) | →View more information from publications. |
Recent Publications on RUNX1: |  |
Detailed molecular and clinical characterization of three patients with 21q deletions.
Lindstrand A, Malmgren H, Sahlen S, Schoumans J, Nordgren A, Ergander U,... | 30th October, 2009
| Department of Molecular Medicine and Surgery, Clinical Genetics Unit,
| Clin Genet. 2009 Oct 23.
DOI Direct Link |
[Molecular mechanisms of myeloproliferative diseases and myelodysplastic syndromes]
Little was known about the mechanisms for myeloproliferative diseases... | 29th October, 2009
| Department of Hematology and Oncology, Research Institute for Radiation
| Nippon Rinsho. 2009 Oct;67(10):1901-5.
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The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis.
The transcription factor RUNX1/AML1 is a master regulator of hematopoietic... | 28th October, 2009
| Cancer Research UK Stem Cell Biology Group, Paterson Institute for Cancer
| Blood. 2009 Oct 26.
DOI Direct Link |
AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms.
Myeloproliferative neoplasms (MPN) are clonal hematopoietic stem cell... | 24th October, 2009
| Department of Hematology and Oncology, Research Institute for Radiation
| Blood. 2009 Oct 22.
DOI Direct Link |
The role of Runx1/AML1 and Evi-1 in the regulation of hematopoietic stem cells.
Lineage-specific transcription factors must be precisely regulated during... | 23rd October, 2009
| Department of Cell Therapy and Transplantation Medicine, University of
| J Cell Physiol. 2009 Oct 21.
DOI Direct Link |
→View more research publications. |
RUNX1 results (if any) from reagent suppliers | 
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