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TP63
| Symbol: | TP63 | | Name(s): | tumor protein p63 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AIS, B(p51A), B(p51B), CUSP, EEC3, KET, LMS, OFC8, RHS, SHFM4, TP73L, p40, p51, p63, p73H, p73L | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17984111 |
global repair may be regulated at multiple levels and suggest a novel role for p63 in modulating repair of DNA damage in human keratinocytes |
| 18048390 |
p63 exhibits several transcriptional and stress-response properties similar to those of p53 |
| 16398404 |
differential regulation of human telomerase reverse transcriptase and vascular endothelial growth factor in p63-positive breast carcinomas may contribute to the clinically more aggressive behavior of these neoplasms |
| 17599745 |
Overexpression of p63 is associated with Merkel cell carcinoma |
| 16842248 |
p63 positivity was found in 8/14 (57%) of uterine serous papillary carcinomas and 9/12 (75%) of associated endometrial intraepithelial carcinomas |
| 16581802 |
An autoregulatory loop directs the tissue-specific expression of p63 through a long-range evolutionarily conserved enhancer. |
| 11957139 |
p63 and p73 expression may represent an early event in head and neck squamous carcinoma tumorigenesis and may function as oncogenes in the development of these tumors. |
| 18203782 |
a good correlation exists between histological grade and p63 protein expression in meningiomas |
| 17525625 |
The combination of p63 and calponin is recommended for analysis of breast papillary lesions. |
| 16258268 |
p63 plays an important role in the regulation of cyclin-dependent kinase inhibitor p57Kip2 expression, a type of regulation that is is subverted in ankyloblepharon, ectodermal defects, and cleft lip/palate (AEC) syndrome p63 mutants. | →View more information from publications. |
Recent Publications on TP63: |  |
Sequence Variant on 3q28 and Urinary Bladder Cancer Risk: Findings from the Los Angeles-Shanghai Bladder Case-Control Study.
Recently, the first genome-wide association study of bladder cancer... | 22nd October, 2009
| 1Department of Preventive Medicine, Keck School of Medicine, Norris
| Cancer Epidemiol Biomarkers Prev. 2009 Oct 20.
DOI Direct Link |
AEC syndrome caused by a novel p63 mutation and demonstrating erythroderma followed by extensive depigmentation.
We present an infant with AEC syndrome due to a novel TP63 mutation... | 21st October, 2009
| Division of Dermatology, Department of Internal Medicine, Washington
| Pediatr Dermatol. 2009 Sep-Oct;26(5):617-8.
DOI Direct Link |
Regulation of VDR by deltaNp63alpha is associated with inhibition of cell invasion.
The p63 transcription factor has a pivotal role in epithelial... | 20th October, 2009
| Department of Biochemistry and Molecular Biology, Boonshoft School of
| J Cell Sci. 2009 Aug 15;122(Pt 16):2828-35. Epub 2009 Jul 21.
DOI Direct Link |
Expanding the phenotypic spectrum of acro-cardio-facial syndrome (ACFS): Exclusion of P63 mutation.
Acro-cardio-facial syndrome (ACFS) is a rare autosomal recessive... | 1st October, 2009
| Department of Pediatrics, Chiang Mai University, Thailand.
| Am J Med Genet A. 2009 Aug;149A(8):1749-53.
DOI Direct Link |
A novel TP63 mutation in family with ADULT syndrome presenting with eczema and hypothelia.
Lung carcinoma development is accompanied by field changes that may have... | 24th September, 2009
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| Am J Med Genet A. 2009 Jul;149A(7):1558-60.
DOI Direct Link |
→View more research publications. |
TP63 results (if any) from reagent suppliers | 
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Human Pluripotent Stem Cell Assessment Primer Pair Panel
TP63. PDX-1. ___. ___. SOX2. SOX2. SOX17. ___. ___. ___. ___. HNF-3b. ___. ___. Primer Pairs - Each vial contains 375 pmoles of lyophilized primer. ...
http://www.rndsystems.com/pdf/SC012.pdf...
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Antibodies to p53 and Related Proteins
human ... TP63(8626), mouse, human, ARR, ELISA (i), WB, pricing ... TP63(8626), human, rat, mouse, ARR, ELISA (i), ICC, IHC (f), IHC (p), IP, WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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Human Pluripotent Stem Cell Antibody Array - R&D Systems
Simultaneously detect the relative levels of these pluripotent stem cell markers in a single sample. alpha-Fetoprotein, GATA-4, TP63/TP73L ...
http://www.rndsystems.com/product_detail_objectname_humanplu...
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p63 (4A4) Antibody sc-8431
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, TP63, 8626, 3q28, NM_003722 · Q9H3D4
...
http://www.scbt.com/datasheet-8431-p63-4a4-antibody.html...
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Stem Cell Kits & Panels - R&D Systems
alpha-Fetoprotein; E-Cadherin; GATA-4; Goosecoid; HCG; HNF-3 beta/FoxA2; Nanog; Oct-3/4; Otx2; PDX-1/IPF1; Snail; SOX2; SOX17; TP63/TP73L; VEGF R2 ...
http://www.rndsystems.com/product_detail_objectname_stemcell...
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Products for Induced Pluripotent Stem (iPS) Cell Research
TP63. 10. AFP. 11. GATA-4. 12. PDX-1. 13. SOX17. 14. HNF-3b. 15. Brachyury. 16. Stella. 17. GAPDH. 18. Positive control. 19. DNA marker. Analytes ...
http://www.rndsystems.com/DAM_public/6464.pdf...
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Mouse/Rat Pluripotent Stem Cell Assessment Primer Pair Panel
TP63/TP73L. RDP-341. NM_011641 (m). NM_019221 (r). 587 (m & r). 8672 (m) ... TP63/TP73L. Human Kit. SC012. Human Pluripotent Stem Cell Assessment Primer ...
http://www.rndsystems.com/pdf/SC015.pdf...
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