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PTCH2


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Gene DB Home
Symbol:PTCH2
Name(s):patched homolog 2 (Drosophila)
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
14613484 PTCH2 isoforms have distinct roles in Hedgehog signalling.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDIndian hedgehogpatched 2--Pubmed
HPRDIndian hedgehog homologPatched 2--Pubmed
HPRDSonic hedgehogpatched 2--Pubmed
HPRDsonic hedgehog preproproteinPatched 2--Pubmed
HPRDSMOHpatched 2--Pubmed
HPRDsmoothenedPatched 2--Pubmed
HPRDPatched 2desert hedgehog preproprotein--Pubmed
HPRDpatched 2Desert hedgehog--Pubmed

Recent Publications on PTCH2:

Pubmed Logo
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Hedgehog signaling is aberrantly activated in glioma, medulloblastoma,...
29th October, 2009
M & M Medical Bioinformatics, Hongo 113-0033, Japan. Curr Mol Med. 2009 Sep;9(7):873-86.
A susceptibility locus on 1p32-1p34 for congenital macrostomia in a Chinese family and identification of a novel PTCH2 mutation.
Keratocystic odontogenic tumors (KCOTs, previously known as odontogenic...
17th April, 2009
Molecular Laboratory for Gene Therapy, Capital Medical University School Am J Med Genet A. 2009 Mar;149A(3):521-4.
DOI Direct Link
[Studies on keratocystic odontogenic tumors]
Keratocystic odontogenic tumors (KCOTs, previously known as odontogenic...
18th February, 2009
Department of Oral Pathology, Peking University School and Hospital of Beijing Da Xue Xue Bao. 2009 Feb 18;41(1):16-20.
Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover.
Patched (Ptc) is a 12-cross membrane protein that binds the secreted...
24th December, 2008
Department of Biochemistry and Biophysics, University of California, San J Biol Chem. 2008 Nov 7;283(45):30964-9. Epub 2008 Sep 2.
DOI Direct Link
Exclusion of patched homolog 2 (PTCH2) as a candidate gene for alopecia X in Pomeranians and Keeshonden.
Patched (Ptc) is a 12-cross membrane protein that binds the secreted...
29th October, 2008
Institute of Genetics, University of Berne, Bremgartenstrasse 109a, Berne, Vet Rec. 2008 Jul 26;163(4):121-3.

View more research publications.

Clinical Trials:

Clinical Trials Logo
A Trial to Evaluate the Safety, Local Tolerability, Pharmacokinetics and Pharmacodynamics of LDE225 on Skin Basal Cell Carcinomas in Gorlin's Syndrome Patients

Patents:

Patents logo
US Patent No.Title
7527971 Adult stem cell lines
6051400 Patched-2 polypeptides and polynucleotides
6268176 TRC8, a gene related to the hedgehog receptor, patched
6348575 Patched-2
6353092 Patched-2 polypeptide

View more patents.

PTCH2 results (if any) from reagent suppliers

Google CSE Logo
PTCH2 (L849) Antibody #2464
PTCH2 (L849) Antibody detects transfected levels of PTCH2 protein. It does not recognize transfected levels of human PTCH1. This antibody also cross-reacts ...
http://www.cellsignal.com/products/2464.html...

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PTCH2 antibodies: Stem Cells > Signaling Pathways > Hedgehog ...
PTCH2 antibodies. ... PTCH2 antibodies. Code. Name. Applications (see key) & Reactivity (see key). Image Abreview Publication. ab3115 · PTCH2 antibody ...
http://www.abcam.com/index.html?t=14836&pt=1&c=4139&ei=&mu=r...

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PTCH2 (L849) Antibody
transfected levels of PTCH2 protein. It does not recognize transfected levels of human PTCH1. ... cellular) surrounding residue Leu849 of human PTCH2. ...
http://www.cellsignal.com/pdf/2464.pdf...

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patched 2 (N-19) Antibody sc-9672
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, PTCH2, 8643, 1p34.1, NM_003738 ...
http://www.scbt.com/datasheet-9672-patched-2-n-19-antibody.h...

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GLI2 (R770) Antibody
PTCH2 (G1191) Antibody #2470. SUFU (C54G2) Rabbit mAb #2520. SUFU (C81H7) Rabbit mAb #2522. Phototope®-HRP Western Blot Detection System, Anti-rabbit IgG, ...
http://www.cellsignal.com/pdf/2585.pdf...

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Cell Surface Molecules / GPCRs
Patched homolog 2 (PTCH2) polyclonal antibody, PAB-11031, $175.00. Phospho- integrin B4 [Y1492] (IGTB4) polyclonal antibody, PAB-11652, $210.00 ...
http://www.orbigen.com/dictionary/cat1089.htm...

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GLI2 (R770) Antibody #2585
2553 GLI1 Antibody · 2271 Shh/Ihh Antibody · 2287 Shh Antibody · 2468 PTCH1 ( C53A3) Rabbit mAb · 2464 PTCH2 (L849) Antibody · 2470 PTCH2 (G1191) Antibody ...
http://www.cellsignal.com/products/2585.html...

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