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VAMP8


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Gene DB Home
Symbol:VAMP8
Name(s):vesicle-associated membrane protein 8 (endobrevin)
Type:protein-coding
Organism:Homo sapiens
Synonyms:EDB
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16110299 Observational study of gene-disease association. (HuGE Navigator)
16690874 Observational study of gene-disease association. (HuGE Navigator)
17975119 Observational study of gene-disease association. (HuGE Navigator)
18073581 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
12130530 VAMP-3 and VAMP-8 are present in human platelets and are required for granule secretion.
16110299 Our findings indicate that VAMP5 and VAMP8 are not involved in POAG in the Dutch population.
16690874 Variants in 2 genes were associated with early-onset myocardial infarct: VAMP8, which is involved in platelet degranulation, and HNRPUL1, which encodes a ribonuclear protein.
16195891 VAMP-8 is unlikely to be a v-SNARE for constitutive exocytosis in HSY cells.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDSynaptosomal associated protein,25Kdvesicle-associated membrane protein 8--Pubmed
HPRDsynaptosomal-associated protein 25 isoform SNAP25AVesicle associated membrane protein 8--Pubmed
HPRDSyntaxin 1Avesicle-associated membrane protein 8--Pubmed
HPRDsyntaxin 1AVesicle associated membrane protein 8--Pubmed
HPRDsyntaxin 3Vesicle associated membrane protein 8--Pubmed
HPRDSyntaxin 4Avesicle-associated membrane protein 8--Pubmed
HPRDsyntaxin 4Vesicle associated membrane protein 8--Pubmed
HPRDSyntaxin 7vesicle-associated membrane protein 8--Pubmed
HPRDsyntaxin 7Vesicle associated membrane protein 8--Pubmed
HPRDVesicle associated membrane protein 8synaptosomal-associated protein 23 isoform SNAP23A--Pubmed

Recent Publications on VAMP8:

Pubmed Logo
A role of VAMP8/endobrevin in surface deployment of the water channel aquaporin 2.
The vesicle-associated-membrane-protein 8 (VAMP8) is highly expressed in...
21st October, 2009
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore Mol Cell Biol. 2009 Oct 19.
DOI Direct Link
A role for endobrevin/VAMP8 in CTL lytic granule exocytosis.
CTL clear virus-infected cells and tumorigenic cells by releasing potent...
16th October, 2009
Membrane Biology Laboratory, Institute of Molecular and Cell Biology, Eur J Immunol. 2009 Oct 14.
DOI Direct Link
Vesicle-associated membrane protein 2 mediates trafficking of alpha5beta1 integrin to the plasma membrane.
Integrins are major receptors for cell adhesion to the extracellular...
14th October, 2009
Department of Biochemistry and Molecular Biology, University of Louisville Exp Cell Res. 2009 Oct 12.
DOI Direct Link
Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo.
Individuals whose platelets lack dense or alpha-granules suffer various...
22nd September, 2009
Division of Hemostasis and Thrombosis, Department of Medicine, Beth Israel Blood. 2009 Jul 30;114(5):1083-90. Epub 2009 Apr 24.
DOI Direct Link
Variations in the requirement for v-SNAREs in GLUT4 trafficking in adipocytes.
Vesicle transport in eukaryotic cells is regulated by SNARE proteins,...
18th September, 2009
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese J Cell Sci. 2009 Oct 1;122(Pt 19):3472-80.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7598080 Diagnostic assay for source of inflammation
7531300 Method of diagnosing breast cancer
7251568 Methods and compositions for regulating bone and cartilage formation
7235358 Methods and compositions for diagnosing and monitoring transplant rejection
7026121 Methods and compositions for diagnosing and monitoring transplant rejection

View more patents.

VAMP8 results (if any) from reagent suppliers

Google CSE Logo
The Abcam catalog
VAMP8 antibodies. ... VAMP8 antibody [EP2629Y]. Flow Cyt, ICC, IP, WB, IHC-P. Images. Rabbit monoclonal. Reacts with: Hu, Ms, Rat ...
http://www.abcam.com/index.html?t=4923&pt=1&c=3330...

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Antibodies to Synaptic Proteins
V7389, Anti-VAMP-8 (N-terminal) antibody produced in rabbit, (polyclonal), affinity isolated antibody, mouse ... Vamp8(22320) rat ... Vamp8(83730) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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VAMP8 proteins and peptides: Immunology > Innate Immunity ...
VAMP8 proteins and peptides. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab79141 · VAMP8 protein (His tag). SDS-PAGE ...
http://www.abcam.com/index.html?t=4923&pt=2&c=480&ei=&mu=ra...

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VAMP-8 - R&D Systems
VAMP-8 (vesicle associated membrane protein 8; also endobrevin) is a 12 kDa member of the synaptobrevin family of proteins. A type IV transmembrane (TM) ...
http://www.rndsystems.com/molecule_detail.aspx?m=4188...

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Endobrevin
Endobrevin (VAMP8). Endosomal fusion protein, member of the R-SNARE family ... v -Fos · VAChT · VAMP 1 · VAMP 2 · VAMP 3 · VAMP 4 · VAMP 5; VAMP 8; Velis ...
http://www.sysy.com/products/endobrevin/index.php?n=VAMP8...

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endobrevin (C-16) Antibody sc-19368
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIMâ„¢ Number. Human, VAMP8, 8673, 2p11.2, NM_003761 ...
http://www.scbt.com/datasheet-19368-endobrevin-c-16-antibody...

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STX1A antibody, E. coli STX 1 & 2 Antibody, Mouse Monoclonal Antibody
Found in a complex with VAMP8 and SNAP23. Interacts with VAPA and SYBU. Subcellular Location: Cell membrane; Single-pass type IV membrane protein. ...
http://www.genwaybio.com/product_info.php?products_id=241591...

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