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ACTN1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17898132 |
Alpha-actinin-1 phosphorylation at Y12 plays a crucial role in pressure-activated cell adhesion and mechanotransduction by facilitating Src recruitment to beta(1)-integrin, and consequently the association of focal adhesion kinase with Src. |
| 17944866 |
Taken together, alpha-actinin not only attaches TRPP3 to the cytoskeleton but also up-regulates TRPP3 channel function. |
| 16430917 |
Results show that the interaction between two species with weak affinity in solution, such as vinculin and alpha-actinin, can be visualized in a membrane-like environment. |
| 15710624 |
the dynamics of alpha-actinin are important for PI 3-kinase-induced reorganization of the actin cytoskeleton |
| 16807302 |
Alpha-actinin plays a role in regulating cell survival through stabilization of focal adhesions and regulation of TNF-alpha-induced survival signaling. |
| 16820411 |
Results show that the interaction between ICAM-5 and alpha-actinin is mediated through binding of positively charged amino acids near the transmembrane domain of ICAM-5, and this interaction may play an important role in neuronal differentiation. |
| 16951376 |
Interaction of alpha 1 actinin with ICAM-1 is required for leukocyte extravasation. |
| 12837758 |
an alpha-actinin-dependent association between the actin cytoskeleton and A2AR trafficking |
| 16195373 |
S1P-induced recruitment of S1P1 to CEM fractions promotes PI3 kinase-mediated Tiam1/Rac1 activation required for alpha-actinin-1/4-regulated cortical actin rearrangement and EC barrier enhancement |
| 16190873 |
GluR4 may regulate its synaptic targeting through phosphorylation-dependent interactions with alpha-Actinin-1 and IQGAP1 | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Actinin alpha 1 | catenin, alpha 1 | - | - | Pubmed |
| HPRD | Actinin alpha 1 | cyclin-dependent kinase 5, regulatory subunit 2 | - | - | Pubmed |
| HPRD | Actinin alpha 1 | synovial sarcoma, X breakpoint 2 interacting protein | - | - | Pubmed |
| HPRD | actinin, alpha 1 | Catenin, alpha 1 | - | - | Pubmed |
| HPRD | actinin, alpha 1 | Cyclin dependent kinase 5, regulatory subunit 2 | - | - | Pubmed |
| HPRD | actinin, alpha 1 | alpha 1 type XVII collagen | - | - | Pubmed |
| HPRD | actinin, alpha 1 | alpha 1 type XVII collagen | - | - | Pubmed |
| HPRD | actinin, alpha 1 | fructose-1,6-bisphosphatase 1 | - | - | Pubmed |
| HPRD | actinin, alpha 1 | fructose-1,6-bisphosphatase 1 | - | - | Pubmed |
| HPRD | actinin, alpha 1 | N-methyl-D-aspartate receptor subunit 2A precursor | - | - | Pubmed |
Recent Publications on ACTN1: |  |
Sequence and expression of the zebrafish alpha-actinin gene family reveals conservation and diversification among vertebrates.
Alpha-actinins are actin microfilament crosslinking proteins. Vertebrate... | 21st October, 2009
| Department of Biochemistry and Cell Biology, Rice University, Houston,
| Dev Dyn. 2009 Nov;238(11):2936-47.
DOI Direct Link |
Development of a multiplex quantitative PCR signature to predict progression in non-muscle-invasive bladder cancer.
In bladder cancer, clinical grade and stage fail to capture outcome. We... | 15th July, 2009
| Department of Urology, Howard Hughes Medical Institute, University of
| Cancer Res. 2009 May 1;69(9):3810-8. Epub 2009 Apr 21.
DOI Direct Link |
Alpha-actinin-4 is selectively required for insulin-induced GLUT4 translocation.
Insulin induces GLUT4 translocation to the muscle cell surface. Using... | 24th October, 2008
| Program in Cell Biology, Hospital for Sick Children, 555 University
| J Biol Chem. 2008 Sep 12;283(37):25115-23. Epub 2008 Jul 10.
DOI Direct Link |
Alternative splicing in colon, bladder, and prostate cancer identified by exon array analysis.
Alternative splicing enhances proteome diversity and modulates... | 7th October, 2008
| Molecular Diagnostic Laboratory, Department of Clinical Biochemistry,
| Mol Cell Proteomics. 2008 Jul;7(7):1214-24. Epub 2008 Mar 18.
DOI Direct Link |
Expression of alpha-actinin-1 in human glomerular mesangial cells in vivo and in vitro.
Recent studies have demonstrated important roles of alpha-actinins in... | 9th July, 2008
| 8701 Watertown Plank
| Exp Biol Med (Maywood). 2008 Jun;233(6):689-93. Epub 2008 Apr 11.
DOI Direct Link |
→View more research publications. |
ACTN1 results (if any) from reagent suppliers | 
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A7811 Monoclonal Anti-α-Actinin (Sarcomeric) antibody produced in ...
indirect immunofluorescence: suitable using human and animal cultured muscle cells. isotype, IgG1. Gene Information, human ... ACTN1(87) ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=A781...
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GeneTex Inc. - Your source for monoclonal, polyclonal, primary ...
ACTN1 antibody (actinin, alpha 1), GTX103240, Rabbit PAb, WB, 100 μl, USD $269.00, -. ACTN2 antibody (actinin, alpha 2), GTX103219, Rabbit ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...
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α-actinin (H-2) Antibody sc-17829
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ACTN1, 87, 14q24.1, NM_001102 ...
http://www.scbt.com/datasheet-17829-alpha-actinin-h-2-antibo...
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A5044 Monoclonal Anti-α-Actinin antibody produced in mouse clone ...
indirect immunofluorescence: 1:200 using cultured chicken fibroblasts. microarray: suitable. isotype, IgM. Gene Information, human ... ACTN1(87). mouse
. ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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α-actinin (H-300) Antibody sc-15335
Human, ACTN1, 87, 14q24.1, NM_001102 · P12814 · 102575. Mouse, Actn2, 11472, 13 A1 ... Mouse, Actn1, 109711, 12 C3, Q7TPR4, N/A. Ordering Information ...
http://www.scbt.com/datasheet-15335-alpha-actinin-h-300-anti...
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Abgent - Cell and Structure Antibodies - Cell_structure
AT1031a, ACTL7B monoclonal antibody (M01), ELISA,WB-Ce,WB-Re, H. AT1032a, ACTN1 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re,WB-Tr, H ...
http://www.abgent.com/products/category/cell_function/cell_s...
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α-actinin (N-19) Antibody sc-7453
Human, ACTN1, 87, 14q24.1, NM_001102 · P12814 · 102575. Human, ACTN2, 88, 1q43, NM_001103 · P35609 ... Mouse, Actn1, 109711, 12 C3, Q7TPR4 ...
http://www.scbt.com/datasheet-7453-alpha-actinin-n-19-antibo...
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