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ABCC3
| Symbol: | ABCC3 | | Name(s): | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18207572 |
Observational study of gene-disease association and pharmacogenomic / toxicogenomic. (HuGE Navigator) |
| 18313914 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17495421 |
Observational study of genotype prevalence. (HuGE Navigator) |
| 18038766 |
induction of ABCC2 and ABCG2 by tBHQ is mediated by the Nrf2/Keap1 system, whereas the induction of ABCC1 may involve a Keap1-dependent but Nrf2-independent mechanism. |
| 17494643 |
MRP1-Pro(1150), MRP2-Pro(1158), and MRP3-Pro(1147) in the cytoplasmic loop 7 differ in their influence on substrate specificity but share a common role in the nucleotide interactions at nucleotide binding domain 2 of these transporters. |
| 17485564 |
Mrp2 and Mrp3 provide alternative routes for the excretion of a glucuronidated substrate from the liver in vivo. |
| 15688370 |
Upregulation of MRP3 expression is associated with pancreatic carcinoma |
| 11820781 |
Expression of MRP3 can be induced by certain nonsteroidal anti-inflammatory drugs (e.g., indomethacin) in a reactive oxygen species-dependent but cyclooxygenase-2-independent manner. |
| 12220224 |
possible role in the removal of bile acids from the liver in cholestasis |
| 15167703 |
Genetic polymorphisms in the MRP3 is associated with liver neoplasms | →View more information from publications. |
Recent Publications on ABCC3: |  |
The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells.
Fasudil, an inhibitor of Rho kinase, is known to suppress tumorigenicity... | 3rd November, 2009
| Department of Thoracic Surgery, Fourth Affiliated Hospital, China Medical
| Biomed Pharmacother. 2009 Oct 17.
DOI Direct Link |
Involvement of drug transporters in the synergistic action of FOLFOX combination chemotherapy.
FOLFOX is a cytostatic drug combination for adjuvant treatment of... | 27th October, 2009
| Department of Internal Medicine VI, Clinical Pharmacology and
| Biochem Pharmacol. 2009 Dec 1;78(11):1366-73. Epub 2009 Jul 19.
DOI Direct Link |
Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2.
Ezetimibe lowers plasma cholesterol levels by inhibiting the uptake of... | 20th October, 2009
| Liver Center, Academic Medical Center, Meibergdreef 69-71, Amsterdam, The
| Drug Metab Dispos. 2009 Aug;37(8):1698-702. Epub 2009 May 14.
DOI Direct Link |
mRNA expression profile of multidrug resistance genes in childhood acute lymphoblastic leukemia. Low expression levels associated with a higher risk of toxic death.
BACKGROUND: Increased activity of multidrug resistance (MDR) genes has... | 14th October, 2009
| Faculty of Medicine of Ribeirao Preto, Department of Genetics, University
| Pediatr Blood Cancer. 2009 Dec;53(6):996-1004.
DOI Direct Link |
ABCC1, ABCC2 and ABCC3 are implicated in the transepithelial transport of the myco-estrogen zearalenone and its major metabolites.
The myco-estrogene zearalenone (ZEA) is a worldwide cereal contaminant,... | 29th September, 2009
| UMR 1233 INRA-ENVL, MTCX, Ecole Nationale Veterinaire de Lyon, 1 av.
| Toxicol Lett. 2009 Oct 28;190(2):215-23. Epub 2009 Jul 30.
DOI Direct Link |
→View more research publications. |
ABCC3 results (if any) from reagent suppliers | 
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Antibodies to Drug Efflux Pumps
ABCC3(8714), human, ICC, IHC (f), WB, pricing. M6442, Monoclonal Anti-MRP5 antibody produced in rat, M5II-54 (monoclonal), tissue culture supernatant ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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Anti-CD105 (FITC) Monoclonal Antibody
Monoclonal Antibody against CD105 (FITC) for use in Flow Cytometry.
http://www.bioreagents.com/products/productDetails/productDe...
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Monoclonal Anti-Breast Cancer Resistance Protein antibody produced ...
(ABCC3), and BCRP (ABCG2), belong to the ABC trans- porter family. They act as efflux pumps, which result in decreased intracellular concentrations of ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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MRP3 (D-15) Antibody sc-5775
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ABCC3, 8714, 17q21.33, NM_003786 ...
http://www.scbt.com/ko/datasheet-5775-mrp3-d-15-antibody.htm...
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Multidrug Resistance Antibodies
M6567, Monoclonal Anti-MRP3 antibody produced in mouse, M3II-21, tissue culture supernatant, human ... ABCC3(8714), human, ICC, IHC (f), WB, pricing ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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MRP3 (D-15) Antibody sc-5775
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, ABCC3, 8714, 17q21.33, NM_003786 ...
http://www.scbt.com/ja/datasheet-5775-mrp3-d-15-antibody.htm...
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MRP3 (H-16) Antibody sc-5774
Humano, ABCC3, 8714, 17q21.33, NM_003786 · O15438 · 604323. camundongo, Abcc3, 76408, 11 D, B2RX12, N/A. Informacoes sobre ordens ...
http://www.scbt.com/pt/datasheet-5774-mrp3-h-16-antibody.htm...
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