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ADAM23


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Gene DB Home
Symbol:ADAM23
Name(s):ADAM metallopeptidase domain 23
Type:protein-coding
Organism:Homo sapiens
Synonyms:MDC3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15862898 Together, these results indicate that ADAM23 down-regulation by methylation in brain tumors is a rare event and it may help explain why brain tumor metastases are rarely found elsewhere in the body.
16103878 ADAM23 is frequently silenced in gastric cancers by homozygous deletion or aberrant promoter methylation.

Recent Publications on ADAM23:

Pubmed Logo
Association and interaction analyses of eight genes under asthma linkage peaks.
BACKGROUND: Linkage studies have implicated the 2q33, 9p21, 11q13 and...
15th October, 2009
Queensland Institute of Medical Research, Brisbane, Australia. Allergy. 2009 Nov;64(11):1623-8.
DOI Direct Link
LGI1-associated epilepsy through altered ADAM23-dependent neuronal morphology.
Most epilepsy genes encode ion channels, but the LGI1 gene responsible for...
3rd October, 2009
Program in Cellular Neuroscience, Neurodegeneration and Repair, Yale Mol Cell Neurosci. 2009 Sep 29.
DOI Direct Link
Characterization of a specific interaction between ADAM23 and cellular prion protein.
ADAMs are transmembrane proteins implicated in several biological...
25th August, 2009
Department of Basic Pathology, Universidade Federal do Parana, Centro Neurosci Lett. 2009 Sep 11;461(1):16-20. Epub 2009 May 27.
DOI Direct Link
Comparative analysis of DNA methylation between primary and metastatic gastric carcinoma.
Metastasis is a multi-step process involving many biomolecular changes and...
12th August, 2009
Department of Pathology, Seoul National University College of Medicine, Oncol Rep. 2009 May;21(5):1251-9.
ADAM23 negatively modulates alpha(v)beta(3) integrin activation during metastasis.
The ADAM23 gene is frequently silenced in different types of tumors, and,...
30th July, 2009
Laboratory of Molecular Biology and Genomics, Ludwig Institute for Cancer Cancer Res. 2009 Jul 1;69(13):5546-52. Epub 2009 Jun 23.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7611839 Methods for diagnosing RCC and other solid tumors
7485468 Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases
7439332 Polypeptide having an activity to support proliferation or survival of hematopoietic stem or progenitor cells
7399832 Metalloprotease-disintegrin ADAM23 (SVPH3-17)
7320880 Polypeptide having an activity to support proliferation or survival of hematopoietic stem cell and hematopoietic progenitor cell, and DNA coding for the same

View more patents.

ADAM23 results (if any) from reagent suppliers

Google CSE Logo
Immunohistochemistry : ADAM23 - R&D Systems
A disintegrin and metalloprotease domain 23 (ADAM23) was detected in paraffin- embedded human spleen sections using 15 µg/mL mouse anti-human ADAM23 ...
http://www.rndsystems.com/ihc_molecule_images.aspx?m=3990...

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ADAM Antibody / ADAM Antibodies
ADAM23 (H-65) Antibody, sc-50482, rabbit IgG, 351-415 (h), WB, IP, IF, ... ADAM23 (I-19) Antibody, sc-67410, goat IgG, Internal (h), WB, IF, ELISA, m, r, h
...
http://www.scbt.com/table-adam.html...

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All ADAM Protein Family | Abcam
ADAM23 antibody - Cytoplasmic domain. WB, ICC/IF. Images. Rabbit polyclonal. Reacts with: Hu, Rat. ab28304 · ADAM23 antibody - Propeptide domain. WB, ICC/IF
...
http://www.abcam.com/index.html?c=3657...

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ADAM23 siRNA (m) sc-61939
Click here for details. suitable control antibody: ADAM23 (I-19): sc-67410; sqRT -PCR Primer also available: ADAM23 (m)-PR: sc-61939, 20 µl ...
http://www.scbt.com/ko/datasheet-61939-adam23-sirna-m.html...

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ADAM30 antibody - Metalloproteinase domain (ab40136) | Abcam
A member of the metalloproteinase family containing disintegrin-like domains ( ADAMs), the function of ADAM23 is still poorly understood. ...
http://www.abcam.com/ADAM30-antibody-Metalloproteinase-domai...

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ADAM23 (H-65) Antibody sc-50482
ADAM23 shRNA (h) Lentiviral Particles, sc-61938-V, 200 µl ... Western blot analysis of ADAM23 expression in mouse brain (A) and rat brain (B) tissue
extract ...
http://www.scbt.com/ko/datasheet-50482-adam23-h-65-antibody....

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Integrin beta 3 antibody [BV4] (ab7167) | Abcam
ADAM23 negatively modulates alpha(v)beta(3) integrin activation during metastasis. Cancer Res 69:5546-52 (2009). Inhib; Human. PubMed: 19549921 ...
http://www.abcam.com/Integrin-beta-3-antibody-BV4-ab7167.htm...

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