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ADAM9
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17704059 |
the ADAM-9 adhesive domain plays a role in regulating the motility of cells by interaction with beta1 integrins and modulates MMP synthesis. |
| 17018608 |
Intracellular ROS and/or hydrogen peroxide, generated by cell stress, regulate ADAM9 expression. ADAM9 may support prostate cancer cell survival and progression. |
| 16311053 |
In conclusion, our findings are consistent with the hypothesis that FHL-2 and ADAM-9 are important modulators of IGFBP-5 actions and are, in part, regulated in a coordinated manner in bone |
| 12535668 |
The results indicate that ADAM9, ADAM10, and ADAM17, members of the disintegrin and metalloprotease family, catalyze alpha-secretory cleavage and therefore act as alpha-secretases in A172 cells. |
| 16806063 |
ADAM9 does not behave as a genuine alpha-secretase but rather acts as an important upstream regulator of ADAM10 activity. |
| 15205330 |
ADAM9 overexpression enhances cell adhesion and invasion of non-small cell lung cancer cells via modulation of other adhesion molecules and changes in sensitivity to growth factors, thereby promoting metastatic capacity to the brain. |
| 15856464 |
In melanoma ADAM-9 protein expression appeared to be restricted to the melanoma cells within the invading front. |
| 12054541 |
cloning of a novel form of human ADAM9 (hADAM9s) which has an alpha-secretase activity for Amyloid Protein Precursor |
| 12484779 |
First evidence is presented of ADAM9 as an insulin-like growth factor binding protein-5 (IGFBP-5) protease produced and secreted by osteoblasts in culture, able to degrade IGFBP-5 with high potency, thereby regulating the critical activity of IGFBP-5. |
| 11955914 |
The downregulated expression of ADAM9 may serve as a marker for anterior polar cataracts. | →View more information from publications. |
Recent Publications on ADAM9: |  |
ADAM9 as a potential target molecule in cancer.
ADAM (a disintegrin and metalloproteinase) proteins have a predominant... | 23rd October, 2009
| Institut Pasteur, Laboratory of Lymphoid Tissue Development, CNRS URA1961,
| Curr Pharm Des. 2009;15(20):2282-7.
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Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9.
Collagen XVII is a transmembrane collagen and the major autoantigen of the... | 20th October, 2009
| Arthritis and Tissue Degeneration Program, Hospital for Special Surgery,
| J Biol Chem. 2009 Aug 28;284(35):23386-96. Epub 2009 Jul 1.
DOI Direct Link |
Inhibition of platelets and tumor cell adhesion by the disintegrin domain of human ADAM9 to collagen I under dynamic flow conditions.
This work aimed to investigate the role of the disintegrin domain of the... | 14th October, 2009
| Departamento de Ciencias Fisiologicas, Universidade Federal de Sao Carlos,
| Biochimie. 2009 Aug;91(8):1045-52. Epub 2009 Jun 6.
DOI Direct Link |
Role of ADAMs in the ectodomain shedding and conformational conversion of the prion protein.
The cellular prion protein (PrP(C)) is essential for the pathogenesis and... | 7th October, 2009
| Proteolysis Research Group, Institute of Molecular and Cellular Biology,
| J Biol Chem. 2009 Aug 21;284(34):22590-600. Epub 2009 Jun 29.
DOI Direct Link |
Involvement of a disintegrin and metalloproteinase 10 and 17 in shedding of tumor necrosis factor-alpha.
Tumor necrosis factor-alpha (TNF-alpha) is initially synthesized as a... | 22nd September, 2009
| Department of Pathomechanisms, Clinical Research Center, National Hospital
| Biochem Cell Biol. 2009 Aug;87(4):581-93.
DOI Direct Link |
→View more research publications. |
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