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FADD


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Gene DB Home
Symbol:FADD
Name(s):Fas (TNFRSF6)-associated via death domain
Type:protein-coding
Organism:Homo sapiens
Synonyms:GIG3, MGC8528, MORT1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17656375 Implication of FGF3 and FADD in human craniofacial disease.
17977957 Increased expression and activation of Fas in beta-cells could constitute a molecular event common to the pathogenesis of both type 1 and type 2 diabetes.
18174230 Observational study of gene-disease association. (HuGE Navigator)
17975136 cancer cells expressing high levels of the Ser(194) phosphorylated isoform of FADD are sensitive to Taxol-induced cell cycle arrest
17911615 Transgenic FADD/caspase-8 play an essential role in maintaining S6 kinase activity during T cell cycle progression.
17235653 The expression of Fas-associated death domain (FADD) in peripheral blood mononuclear cells was significantly decreased in SLE patients.
17511679 Reduced expression of the proapoptotic proteins FADDor overexpression of Bcl-2 improved myoblast transplantation survival.
17031492 Endoplasmic reticulum, ER-bound RTN3 protein recruited endogenous FADD to the ER membrane and subsequently initiated caspase-8 cascade, including activation of caspase-8, processing of Bid and release of cytochrome c from mitochondria.
12196516 dominant negative form inhibits cytochrome c release in response to TRAIL receptor 2 or CD95
15173180 binding of Fas-associated death domain (FADD) to the tumor necrosis factor-related apoptosis-inducing ligand receptor DR5 is regulated by the death effector domain of FADD

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDATP-binding cassette, sub-family A member 1Fas-associated via death domain--Pubmed
HPRDATP-binding cassette, sub-family A member 1Fas-associated via death domain--Pubmed
BIND-Fas-associated via death domainFas interacts with FADD.-Pubmed
BIND-Fas-associated via death domainAn unspecified isoform of Fas interacts with FADD.-Pubmed
HPRDtumor necrosis factor receptor superfamily, member 6 isoform 1 precursorFas-associated via death domain--Pubmed
HPRDtumor necrosis factor receptor superfamily, member 6 isoform 1 precursorFas-associated via death domain--Pubmed
HPRDCaspase 8Fas-associated via death domain--Pubmed
BIND-Fas-associated via death domaincaspase-8 interacts with FADD.-Pubmed
HPRDcaspase 8 isoform A precursorFADD--Pubmed
BINDCaspase-8 precursor [Contains: Caspase-8 ...Fas-associated via death domainCASP8 (caspase-8) interacts with FADD.-Pubmed

Recent Publications on FADD:

Pubmed Logo
Perfluorononanoic Acid-induced Apoptosis in Rat Spleen Involves Oxidative Stress and the Activation of Caspase-Independent Death Pathway.
Perfluoroalkyl acid (PFAA)-induced apoptosis has been reported in many...
3rd November, 2009
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Toxicology. 2009 Oct 27.
DOI Direct Link
The IL-8 production by streptococcal pyrogenic exotoxin B.
We have previously identified alpha(v)beta(3) and Fas as receptors for the...
27th October, 2009
Institute of Basic Medical Sciences, Department of Biochemistry, National Exp Biol Med (Maywood). 2009 Nov;234(11):1316-26.
DOI Direct Link
Increased death receptor pathway of apoptotic signaling in septic mouse aorta: effect of systemic delivery of FADD siRNA.
Recent evidence suggests that apoptotic cell death plays an important role...
27th October, 2009
University of Toyama. Am J Physiol Heart Circ Physiol. 2009 Oct 23.
DOI Direct Link
Impaired TNFalpha-induced A20 expression in E1A/Ras-transformed cells.
BACKGROUND: Tumour necrosis factor (TNF) is capable of activating the cell...
15th October, 2009
The Campbell Family Institute of Breast Cancer Research, Ontario Cancer Br J Cancer. 2009 Nov 3;101(9):1555-64. Epub 2009 Oct 13.
DOI Direct Link
CD95/Fas downregulation in lymphoma cells through acquired alkyl-lysophospholipid resistance; partial role of associated sphingomyelin deficiency.
The alkyl-lysophospholipid (ALP)...
15th October, 2009
Biochem J. 2009 Oct 14.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Carinal Biopsy Study

Patents:

Patents logo
US Patent No.Title
7518575 Plasma display device and method of driving the same
7553632 Luminogenic and nonluminogenic multiplex assay
7553821 Methods for selectively modulating survivin apoptosis pathways
7553955 Molecular beacons, methods and kits for detecting DNA damage response
7563462 Methods for modulating eicosanoid metabolism

View more patents.

FADD results (if any) from reagent suppliers

Google CSE Logo
FADD Antibody / FADD Antibodies
FADD Antibody / FADD Antibodies. ... FADD specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-fadd.html...

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FADD antibody (ab24533) | Abcam
Rabbit polyclonal to FADD. FADD (Fas Associated Death Domain) is an apoptosis adapter molecule enabling transduction of the apoptosis signal initiated via ...
http://www.abcam.com/fadd-antibody-ab24533.html...

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FADD Antibody (Human Specific) #2782
Western blot analysis of extracts from Jurkat and HeLa cells treated with 4 mM hydroxyurea or 1 µg/ml nocodazole (each for 20 hours), using FADD Antibody ...
http://www.cellsignal.com/products/2782.html...

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p-FADD (Ser 194) Antibody sc-12439
See how others have used p-FADD (Ser 194): sc-12439 antibody and or p-FADD ... Phosphorylation of FADD (Fas-associated death domain protein) at serine 194 ...
http://www.scbt.com/datasheet-12439-p-fadd-ser-194-antibody....

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Phospho-FADD (Ser194) Antibody (Human Specific) #2781
Phospho-FADD (Ser194) Antibody (Human Specific) detects endogenous levels of human FADD protein only when phosphorylated at serine 194. ...
http://www.cellsignal.com/products/2781.html...

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p-FADD (Ser 191) Antibody sc-33399
rabbit polyclonal IgG, 200µg/ml; epitope corresponding to phosphorylated Ser 191 of FADD of mouse origin; recommended for detection of Ser 191 ...
http://www.scbt.com/datasheet-33399-p-fadd-ser-191-r-antibod...

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Fadd antibody, FADD (Fas (TNFRSF6)-associated via death domain ...
Buy quality rabbit Fadd antibody (interacts with mouse), anti-Fadd, FADD (Fas ( TNFRSF6)-associated via death domain) antibody, rabbit polyclonal antibody, ...
http://www.genwaybio.com/product_info.php?products_id=43791...

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