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ACTN2


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Symbol:ACTN2
Name(s):actinin, alpha 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
12140183 Spectrin-like repeats from dystrophin and alpha-actinin-2 are not functionally interchangeable.
17110593 Association of Ca2+-activated K+ channel with alpha-actinin2 localizes channel to entry of external Ca(2+) source, which regulates channel function.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDAlpha actinin 2selectin E precursor--Pubmed
HPRDAlpha actinin 2N-methyl-D-aspartate receptor subunit 2B precursor--Pubmed
HPRDAlpha actinin 2postsynaptic density protein 95--Pubmed
HPRDActinin alpha 2a disintegrin and metalloprotease domain 12 isoform 1 preproprotein--Pubmed
HPRDAlpha actinin 2a disintegrin and metalloprotease domain 12 isoform 1 preproprotein--Pubmed
HPRDAlpha actinin 2discs, large homolog 1--Pubmed
HPRDActinin alpha 2LIM domain binding 3 isoform 1--Pubmed
HPRDActinin alpha 2synovial sarcoma, X breakpoint 2 interacting protein--Pubmed
HPRDAlpha actinin 2palladin--Pubmed
HPRDAlpha actinin 2myozenin 2--Pubmed

Recent Publications on ACTN2:

Pubmed Logo
Sequence and expression of the zebrafish alpha-actinin gene family reveals conservation and diversification among vertebrates.
Alpha-actinins are actin microfilament crosslinking proteins. Vertebrate...
21st October, 2009
Department of Biochemistry and Cell Biology, Rice University, Houston, Dev Dyn. 2009 Nov;238(11):2936-47.
DOI Direct Link
alpha-actinin-3 and performance.
The human sarcomeric alpha-actinins (ACTN2 and ACTN3) are major structural...
22nd August, 2009
Institute for Neuroscience and Muscle Research, Children's Hospital at Med Sport Sci. 2009;54:88-101. Epub 2009 Aug 17.
DOI Direct Link
Assignment of the 1H, 13C and 15N resonances of the calponin homology-2 domain of alpha-actinin-4.
We report the assignment of the 110 amino acid second calponin homology...
20th August, 2009
School of Molecular and Biomedical Science, University of Adelaide, Biomol NMR Assign. 2008 Dec;2(2):195-7. Epub 2008 Sep 27.
DOI Direct Link
Defective myotilin homodimerization caused by a novel mutation in MYOT exon 9 in the first Japanese limb girdle muscular dystrophy 1A patient.
Myotilin is a muscle-specific Z disk protein. Several missense mutations...
1st July, 2009
Department of Neuromuscular Research, National Institute of Neuroscience, J Neuropathol Exp Neurol. 2009 Jun;68(6):701-7.
DOI Direct Link
A genome scan for positive selection in thoroughbred horses.
Thoroughbred horses have been selected for exceptional racing performance...
9th June, 2009
Animal Genomics Laboratory, School of Agriculture, Food Science and PLoS One. 2009 Jun 2;4(6):e5767.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
7588767 Microorganisms for therapy
7208313 Combined growth factor-deleted and thymidine kinase-deleted vaccinia virus vector
7208270 Method for diagnosing a person having multiple sclerosis
6727063 Single nucleotide polymorphisms in genes

View more patents.

ACTN2 results (if any) from reagent suppliers

Google CSE Logo
ACTN2 antibody - GeneTex Inc. - Your source for monoclonal ...
Product Description, Rabbit polyclonal antibody to ACTN2 (actinin, alpha 2) ... Specificity, This antibody is specific to the Human ACTN2 protein. ...
http://www.genetex.com/WebPage/Product/ProductDetail.aspx?Ca...

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α-actinin (N-19) Antibody sc-7453
Mouse, Actn2, 11472, 13 A1, Q9JI91, N/A. Mouse, Actn3, 11474, 19 A, O88990, N/A. Mouse, Actn4, 60595, 7 A3, P57780, N/A. Mouse, Actn1, 109711, 12 C3, Q7TPR4 ...
http://www.scbt.com/datasheet-7453-alpha-actinin-n-19-antibo...

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GeneTex Inc. - Your source for monoclonal, polyclonal, primary ...
ACTN2 antibody (actinin, alpha 2), GTX103219, Rabbit PAb, WB, 100 μl, USD $269.00, -. ACTN2 antibody (actinin, alpha 2), GTX111167, Rabbit ...
http://www.genetex.com/WebPage/Product/Catalog.aspx?Type=Sea...

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α-actinin-2 (A-25) Antibody sc-130928
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ACTN2, 88, 1q43, P35609 ...
http://www.scbt.com/datasheet-130928-alpha-actinin-2-a-25-an...

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Sarcomeric Alpha Actinin antibody [EA-53] (ab9465) | Abcam
ACTN2 encodes a muscle-specific, alpha actinin isoform that is expressed in both ... ACTN2 has the ability to form both homo- and heterodimers (with ACTN3). ...
http://www.abcam.com/Sarcomeric-Alpha-Actinin-antibody-EA-53...

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α-actinin (B-12) Antibody sc-166524
Human, ACTN2, 88, 1q43, NM_001102, NM_001103, NM_001104, NM_001130004, NM_001130005, NM_004924 · P35609, n/a. Human, ACTN3, 89, 11q13.1, NM_001102, ...
http://www.scbt.com/datasheet-166524-alpha-actinin-b-12-anti...

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ACTN3 antibody (ab65067) | Abcam
It is a Homodimer and also forms heterodimers with ACTN2 and interacts with MYOZ1. Although about 18% of the world population lack a functional ACTN3 gnen
...
http://www.abcam.com/ACTN3-antibody-ab65067.html...

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