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BANF1


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Symbol:BANF1
Name(s):barrier to autointegration factor 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:BAF, BCRP1, D14S1460, MGC111161
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18005698 We now show that BAF acts as a potent inhibitor of poxvirus replication unless its DNA-binding activity is blocked by B1-mediated phosphorylation.
17519288 These results indicate that barrier-to-autointegration factor is required for the integrity of the nuclear lamina and normal progression of S phase in human cells.
11792821 The barrier-to-autointegration factor (BAF)-binding domain of emerin is located at the emerin N-terminus (residues 70-178) and includes the LEM-domain.
11792822 BAF is required for the assembly of emerin and A-type lamins at the reforming nuclear envelope during telophase and may mediate their stability in the subsequent interphase.
14645565 BAF protein was detected in activated but not resting CD4+ T-lymphocytes. BAF bound directly to both p55 Gag and its cleaved product, matrix.
15109603 Data describe the mobility of barrier-to-autointegration factor to its partners emerin, LAP2 beta, and MAN1 in the nuclear membrane of living HeLa cells.
12663813 report that BAF protein is a component of preintegration complexes isolated from HIV-1-infected cells
14523012 HB and barrier-to-autointegration factor are the same protein
15546916 LAP2alpha and BAF transiently localize to telomeres and specific regions on chromatin during nuclear assembly
16204256 phosphorylation at Ser175 regulates the dissociation of emerin from BAF

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDEmerinHomo sapiens breakpoint cluster region protein 1 mRNA, complete cds.--Pubmed
HPRDemerinBANF1--Pubmed
BINDemerinbarrier to autointegration factor 1Emerin interacts with BAF.-Pubmed
HPRDThymopoietinHomo sapiens breakpoint cluster region protein 1 mRNA, complete cds.--Pubmed
HPRDthymopoietin isoform alphaBANF1--Pubmed
HPRDHomo sapiens breakpoint cluster region protein 1 mRNA, complete cds.Homo sapiens breakpoint cluster region protein 1 mRNA, complete cds.--Pubmed
BINDbarrier to autointegration factor 1barrier to autointegration factor 1Interaction between BAF (PDB ID: 2EZZ_B) and BAF (PDB ID: 2EZZ_A).-Pubmed

Recent Publications on BANF1:

Pubmed Logo
Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly.
Assembly of the nuclear envelope (NE) in telophase is essential for higher...
13th November, 2008
CREST Research Project, Kobe Advanced ICT Research Center, National J Cell Sci. 2008 Aug 1;121(Pt 15):2540-54. Epub 2008 Jul 15.
DOI Direct Link
LAP2zeta binds BAF and suppresses LAP2beta-mediated transcriptional repression.
Proteins of the nuclear envelope have been implicated as participating in...
2nd July, 2008
Sheba Cancer Research Center and the Institute of Hematology, Chaim Sheba Eur J Cell Biol. 2008 May;87(5):267-78. Epub 2008 Apr 9.
DOI Direct Link
Gene expression in early stage cervical cancer.
OBJECTIVE: Pelvic lymph node metastases are the main prognostic factor for...
21st March, 2008
Department of Gynaecologic Oncology, Academic Medical Center, Meibergdreef Gynecol Oncol. 2008 Mar;108(3):520-6. Epub 2008 Jan 11.
DOI Direct Link
Poxviral B1 kinase overcomes barrier to autointegration factor, a host defense against virus replication.
Barrier to autointegration factor (BAF) is a DNA-binding protein found in...
12th December, 2007
Department of Microbiology and Molecular Genetics, Medical College of Cell Host Microbe. 2007 May 17;1(3):187-97.
DOI Direct Link
Barrier-to-autointegration factor--a BAFfling little protein.
Barrier-to-autointegration factor (BAF) is an abundant, highly conserved,...
20th October, 2007
Department of Genetics, The Institute of Life Sciences, The Hebrew Trends Cell Biol. 2007 Apr;17(4):202-8. Epub 2007 Feb 21.
DOI Direct Link

View more research publications.

BANF1 results (if any) from reagent suppliers

Google CSE Logo
BANF1 Antibody (NT) Barrier to autointegration factor
BANF1 antibody can be used for detection of BANF1 by Western blot at 0.5 – 1 μg/ ml.,
http://www.prosci-inc.com/shop/catalog1/BANF1-Antibody-p-647...

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Anti-BANF1 (NT)
Antibodies , Primary Antibodies , Chromatin , Anti-BANF1 (NT); Host: rabbit polyclonal; Species Reactivity: human, mouse, rat; Application: WB, IF, ELISA.
http://www.anaspec.com/products/product.asp?id=47417...

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Emerin Antibody a serine-rich nuclear membrane member of the ...
Each family member, including Emerin, has an ~40 amino acid LEM-domains that binds barrier-to-autointegration (BANF1), a conserved chromatin protein that ...
http://www.prosci-inc.com/shop/catalog1/Emerin-Antibody-p-64...

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BAF (ZZ-52) Antibody sc-100978
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, BANF1, 8815, 11q13.1, NM_003860 ...
http://www.scbt.com/datasheet-100978-baf-zz-52-antibody.html...

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HIV Antibodies and HIV Related Antibodies :: Page 1
ARR3 Antibody, XW-7690, H, WB, Arrestin-C, Retinal cone arrestin-3. BANF1 Antibody, 4017, H, M, E, WB, IF, (CT) Barrier to autointegration factor ...
http://www.prosci-inc.com/shop/catalog1/HIV-Antibodies-and-H...

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Abgent - Cell and Function Antibodies
AT1266aNEW, BANF1 monoclonal antibody (M04), ELISA,IF,IHC-P,S-ELISA,WB-Re, H. AT1267aNEW, BANF1 monoclonal antibody (M07), ELISA,IF,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...

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New Antibodies :: ProSci Incorporated
BANF1 Antibody (CT) · BANF1 Antibody (NT) · BAP3 Antibody (NT) · BAP3 Antibody ( NT2) · Beta-actin Antibody (CT) · Beta-actin Antibody (NT) ...
http://www.prosci-inc.com/new-antibodies.php...

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