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CFLAR
| Symbol: | CFLAR | | Name(s): | CASP8 and FADD-like apoptosis regulator | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, USURPIN, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17726263 |
Caspase-8 and cFLIP are upregulated during colorectal carcinogenesis. |
| 17932249 |
reconstitution of ATM kinase activity decreases FLIP protein levels and restores Fas sensitivity in Hodgkin lymphoma-derived cells |
| 17450141 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17988665 |
IFN-alpha causes a transient upregulation of c-FLIP expression, at least through PKCalpha-mediated activation of NF-kappaB |
| 16077198 |
Cycloheximide sensitizes colorectal tumor cells to TNF-alpha induced apoptosis by reducing FLIP levels. |
| 17912957 |
Human keratinocytes were transfected with either Flip, Faim, or Lifeguard (LFG). Our results suggest that heterotopic expression of antiapoptotic proteins can induce the resistance of keratinocytes to a major mechanism of rejection. |
| 14662022 |
Akt activity promotes human gastric cancer cell survival against TRAIL-induced apoptosis via upregulation of FLIP(S), and that the cytotoxic effect of TRAIL can be enhanced by modulating the Akt/FLIP(S) pathway in human gastric cancers. |
| 17697742 |
VPA significantly increased sensitivity of leukemic cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and led to downregulation of c-FLIP (L) expression. |
| 16740746 |
The NFkappaB-mediated overexpression of cFLIP(long)represent alternative mechanisms for deregulating the extrinsic apoptotic pathway in LBCL subtypes defined by gene expression profiling. |
| 17440816 |
Downregulation of either FLIP or XIAP but not Bcl-2 restored sensitivity of Colo320 cells to Apo2L/TRAIL. | →View more information from publications. |
Recent Publications on CFLAR: |  |
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation.
Hedgehog signaling is aberrantly activated in glioma, medulloblastoma,... | 29th October, 2009
| M & M Medical Bioinformatics, Hongo 113-0033, Japan.
| Curr Mol Med. 2009 Sep;9(7):873-86.
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The IKK2/NF-{kappa}B pathway suppresses MYC-induced lymphomagenesis.
Deregulated c-MYC is found in a variety of cancers where it promotes... | 23rd October, 2009
| Institute of Physiological Chemistry, University of Ulm, Germany.
| Blood. 2009 Sep 17;114(12):2448-58. Epub 2009 Jul 23.
DOI Direct Link |
GLUT1-induced cFLIP expression promotes proliferation and prevents apoptosis in vascular smooth muscle cells.
Enhanced expression of the facilitative glucose transporter, GLUT1, has... | 6th October, 2009
| Department of Internal Medicine, University of Michigan Medical School,
| Am J Physiol Cell Physiol. 2009 Sep;297(3):C759-65. Epub 2009 Jul 8.
DOI Direct Link |
Abundant c-Fas-associated death domain-like interleukin-1-converting enzyme inhibitory protein expression determines resistance of T helper 17 cells to activation-induced cell death.
Activation-induced cell death (AICD) plays an important role in peripheral... | 22nd September, 2009
| Departments of Immunology and Blood and Marrow Transplantation, H. Lee
| Blood. 2009 Jul 30;114(5):1026-8. Epub 2009 May 8.
DOI Direct Link |
The histone deacetylase inhibitor suberoylanilide hydroxamic acid sensitises human hepatocellular carcinoma cells to TRAIL-induced apoptosis by TRAIL-DISC activation.
This paper shows that the histone deacetylase inhibitor SAHA sensitised at... | 16th September, 2009
| Dipartimento di Scienze Biochimiche, Universita di Palermo, Policlinico,
| Eur J Cancer. 2009 Sep;45(13):2425-38. Epub 2009 Jul 28.
DOI Direct Link |
→View more research publications. |
CFLAR results (if any) from reagent suppliers | 
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Anti-CFLAR Polyclonal Antibody
Polyclonal Antibody against CFLAR for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...
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CFLAR monoclonal antibody (M01)
Immunofluorescence of monoclonal antibody to CFLAR (AT1508a) on HeLa cell . ... CFLAR monoclonal antibody (M01), clone 2F12 Western Blot analysis of CFLAR ...
http://www.abgent.com/products/catalog_no/AT1508a_CFLAR_mono...
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CKOZFN1011 CompoZr™ Knockout ZFN Kit human CFLAR (NM_003879)
CKOZFN1011 CompoZr Knockout ZFN Kit human CFLAR (NM_003879) CompoZr Knockout ZFNs create targeted double strand breaks at a gene specific target locus.
http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
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Purified Anti-Caspase-8 Antibody - BioLegend
This caspase interacts with FADD, CFLAR, and PEA15 proteins. ... Interaction: FADD, CFLAR, PEA15; isoform 9 interacts at the ER with a complex containing ...
http://www.biolegend.com/purified-anti-caspase-8-antibody-20...
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FLIPS/L (G-11) Antibody sc-5276
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CFLAR, 8837, 2q33.1, NM_003879 ...
http://www.scbt.com/datasheet-5276-flips-l-g-11-antibody.htm...
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Apoptosis Antibodies :: Page 9
CDKN1A Antibody, XW-7422, H, M, R, WB, Wild type p53 activated fragment-1 (p21). CFLAR Antibody, 49-272, H, WB, IHC, CASP8 And FADD-like Apoptosis Regulator ...
http://www.prosci-inc.com/shop/catalog1/Apoptosis-Antibodies...
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FLIPL (M-18) Antibody sc-7109
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Cflar, 12633, 1 C1.3, O35732 ...
http://www.scbt.com/datasheet-7109-flipl-m-18-antibody.html...
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