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CDK5R1
| Symbol: | CDK5R1 | | Name(s): | cyclin-dependent kinase 5, regulatory subunit 1 (p35) | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | CDK5P35, CDK5R, MGC33831, NCK5A, p23, p25, p35, p35nck5a | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18053171 |
the involvement of 3'-UTR in the modulation of CDK5R1 expression |
| 16425041 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17491008 |
p35 is a microtubule-associated protein that modulates microtubule dynamics |
| 14976144 |
Expression of p35 and CDK5 in insulin-producing beta-cellsis new signaling pathway controlled by glucose, and its functional role may comprise regulation of various biological processes in beta-cells, such as expression of the insulin gene. |
| 15741232 |
an early event in neuronal cell death is p25/Cdk5-mediated retinoblastoma phosphorylation |
| 12859671 |
Neither the CDK5 activator p25 immunoreactivity nor the p25/p35 ratio was elevated in Alzheimer disease brains or in other tauopathies (n = 34) compared with controls (n = 11) |
| 15175076 |
significantly lower levels of cyclin-dependent kinase 5, regulatory subunit 1 (p35) gene transcripts were detected in gangliogliomas compared to controls |
| 17060323 |
p35 employs pathways distinct from that used by Cdk5 for transport to the nucleus |
| 12826674 |
p25-Cdk5 is responsible for the mitotic-like phosphoepitopes present in neurofibrillary tangles |
| 11784720 |
Like p25, p29 was more stable than p39 and caused redistribution of Cdk5 in cortical neurons. Our data suggest that neurotoxic insults lead to calpain-mediated conversion of p39 to p29, which might contribute to deregulation of Cdk5. | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | amphiphysin isoform 1 | cyclin-dependent kinase 5, regulatory subunit 1 | - | - | Pubmed |
| HPRD | amphiphysin isoform 1 | cyclin-dependent kinase 5, regulatory subunit 1 | - | - | Pubmed |
| BIND | amphiphysin isoform 1 | cyclin-dependent kinase 5, regulatory subunit 1 | Amphiphysin 1 interacts with p35. This interaction was modeled on a demonstrated interaction between human amphiphysin 1 and rat p35. | - | Pubmed |
| HPRD | calcium/calmodulin-dependent protein kinase IIA isoform 1 | Cyclin dependent kinase 5, regulatory subunit 1 | - | - | Pubmed |
| BIND | cyclin-dependent kinase 5 | cyclin-dependent kinase 5, regulatory subunit 1 | Cdk5 interacts with p35. | - | Pubmed |
| BIND | cyclin-dependent kinase 5 | cyclin-dependent kinase 5, regulatory subunit 1 | p35 interacts with Cdk5. This interaction was modeled on a demonstrated interaction between bovine p35 and human Cdk5. | - | Pubmed |
| HPRD | cyclin-dependent kinase 5 | cyclin-dependent kinase 5, regulatory subunit 1 | - | - | Pubmed |
| HPRD | cyclin-dependent kinase 5 | cyclin-dependent kinase 5, regulatory subunit 1 | - | - | Pubmed |
| HPRD | cyclin-dependent kinase 9 | cyclin-dependent kinase 5, regulatory subunit 1 | - | - | Pubmed |
| HPRD | PAK1 | cyclin-dependent kinase 5, regulatory subunit 1 | - | - | Pubmed |
Recent Publications on CDK5R1: |  |
Cloning and spatio-temporal expression of porcine CDK5 and CDK5R1(p35) genes.
Cyclin-dependent kinase 5 (CDK5) is a serine/threonine kinase homologue... | 3rd October, 2009
| Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction
| Anim Biotechnol. 2009;20(3):133-43.
DOI Direct Link |
Epistasis between tau phosphorylation regulating genes (CDK5R1 and GSK-3beta) and Alzheimer's disease risk.
OBJECTIVE: Glycogen synthase kinase-3beta (GSK-3beta) and cyclin-dependent... | 8th September, 2009
| Neurology Service and Centro de Investigacion Biomedica en Red sobre
| Acta Neurol Scand. 2009 Aug;120(2):130-3. Epub 2008 Dec 22.
DOI Direct Link |
The 3' untranslated region of human Cyclin-Dependent Kinase 5 Regulatory subunit 1 contains regulatory elements affecting transcript stability.
BACKGROUND: CDK5R1 plays a central role in neuronal migration and... | 26th March, 2008
| Department of Biology and Genetics, Medical Faculty, University of Milan,
| BMC Mol Biol. 2007 Dec 3;8:111.
DOI Direct Link |
Mutations and novel polymorphisms in coding regions and UTRs of CDK5R1 and OMG genes in patients with non-syndromic mental retardation.
Mental retardation (MR) is displayed by 57% of NF1 patients with... | 28th March, 2007
| Department of Biology and Genetics, Medical Faculty, University of Milan,
| Neurogenetics. 2006 Mar;7(1):59-66. Epub 2006 Jan 20.
DOI Direct Link |
Association of cyclin-dependent kinase 5 and neuronal activators p35 and p39 complex in early-onset Alzheimer's disease.
Malfunctioning of cyclin-dependent kinase 5 (CDK5) through aberrant... | 19th August, 2005
| Department of Molecular Genetics, Flanders Interuniversity Institute for
| Neurobiol Aging. 2005 Aug-Sep;26(8):1145-51. Epub 2004 Dec 22.
DOI Direct Link |
→View more research publications. |
CDK5R1 results (if any) from reagent suppliers | 
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CDK5R1(p35) Antibody (N-term)
Formalin-fixed and paraffin-embedded human brain tissue reacted with CDK5R1(p35) Antibody (N-term) (Cat.#AP7743a), which was peroxidase-conjugated to the ...
http://www.abgent.com/products/catalog_no/AP7743a_CDK5R1_p35...
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p35 (N-20) Antibody sc-821
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CDK5R1, 8851, 17q11.2, NM_003885 ...
http://www.scbt.com/datasheet-821-p35-n-20-antibody.html...
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Antibodies to Cell Cycle Regulators
IgG fraction of antiserum, rat ... Cdk5r1(116671) human ... CDK5R1(8851), human, rat, ARR, WB, pricing. P0357, Anti-p57Kip2 antibody produced in rabbit ...
https://www.sigmaaldrich.com/etc/controller/controller-page....
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Abgent - Phosphorylation Antibodies - Phosphorylation
AP7743b, CDK5R1(p35) Antibody (C-term), IHC, E, H. AP7743a, CDK5R1(p35) Antibody (N-term), IHC, E, H. AP7742bNEW, CDK5R2(p39) Antibody (C-term), IHC, E, H ...
http://www.abgent.com/products/category/protein_modification...
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Search Results
Monoclonal Anti-CDK5R1 antibody produced in mouse (1). 別名: Anti-CDK5P35, Anti- CDK5R, Anti-cyclin-dependent kinase 5, regulatory subunit 1 (p35), ...
http://www.sigmaaldrich.com/catalog/Lookup.do?D7=0&D10=p35&N...
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,OR(LOCATION:US,LOCATION:0))&N3=mode%252520matchpartialmax&N5=Product%252520Name%252520or%252520No.&N4=p35&N25=14574647&N1=S_ID&ST=RS&F=PR&LangOvrride=ja_JP) |
ERBB2 protein, c-erbB2 Human recombinant protein
Products similar to ERBB2 protein: IgG 200kDa + 68kDa Neurofilament [SPM145] ( ready-to-use), IgG · CDK5R1, IgG · NEUROD1 (neurogenic differentiation 1), IgG
...
http://www.genwaybio.com/product_info.php?products_id=46053...
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Cyclic-Dependent Kinase (CDK)
P0232, Monoclonal Anti-p35 (Cdk5 Regulator) antibody produced in mouse, ES19 and ES24 (monoclonal), purified immunoglobulin, human ... CDK5R1(8851) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...
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