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IER3
| Symbol: | IER3 | | Name(s): | immediate early response 3 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | DIF-2, DIF2, GLY96, IEX-1, IEX-1L, IEX1, PRG1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18026799 |
This study indicates that an evaulation of IEX-1 expression may be clinically useful for predicting patient prognosis in pancreatic cancer. |
| 17704804 |
Modulates NF-kappaB-dependent antiapoptotic protection and thereby exerts tumor-suppressive potential. |
| 11844788 |
regulation by p53 tumor suppressor and Sp1 |
| 15767410 |
concluded that IEX-1 mRNA is not preferentially degraded during HSV-1 infection and that HSV-1 instead inhibits the normal turnover of this mRNA |
| 16960879 |
IEX-1 plays an important role in astrocytic differentiation of human glioma cells and that IEX-1 functions at downstream of PKA. |
| 12356731 |
IEX-1 is a new type of ERK substrate that has a dual role in ERK signaling by acting both as an ERK downstream effector mediating survival and as a regulator of ERK activation |
| 12743274 |
failure of IEX-1 to express its protein reflects the numerous mechanisms by which HSV-1 thwarts the cells from expressing its genes after infection |
| 15451437 |
Our data suggest that IEX-1 may regulate apoptosis by directly interacting with various proteins involved in the control of apoptotic pathways. |
| 12032839 |
Characterization of a novel hexameric repeat DNA sequence in the promoter of the immediate early gene, IEX-1, that mediates 1alpha,25-dihydroxyvitamin D(3)-associated IEX-1 gene repression. |
| 15781630 |
We found that p73beta targets the apoptotic program at multiple levels: facilitating caspase activation through p53-dependent signals and inducing p57KIP2, while down-regulating c-IPA1 and IEX1 through a p53-independent mechanism. | →View more information from publications. |
Recent Publications on IER3: |  |
Rearrangements and amplification of IER3 (IEX-1) represent a novel and recurrent molecular abnormality in myelodysplastic syndromes.
IER3 (formerly IEX-1) encodes a 27-kDa glycoprotein that regulates death... | 24th September, 2009
| Mayo Clinic,
| Cancer Res. 2009 Oct 1;69(19):7518-23. Epub 2009 Sep 22.
DOI Direct Link |
The virion-packaged endoribonuclease of herpes simplex virus 1 cleaves mRNA in polyribosomes.
The virion host shutoff protein product of the U(L)41 gene of herpes... | 26th August, 2009
| The Marjorie B. Kovler Viral Oncology Laboratories, University of Chicago,
| Proc Natl Acad Sci U S A. 2009 Jul 21;106(29):12139-44. Epub 2009 Jul 7.
DOI Direct Link |
Gene expression profiling of bone marrow endothelial cells in patients with multiple myeloma.
PURPOSE: To determine a "gene/molecular fingerprint" of multiple myeloma... | 20th August, 2009
| Department of Internal Medicine and Clinical Oncology, University of Bari
| Clin Cancer Res. 2009 Sep 1;15(17):5369-78. Epub 2009 Aug 18.
DOI Direct Link |
Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.
In order to identify new genes with differential expression in early... | 17th July, 2009
| Molecular and Population Genetics Laboratory, London Research Institute,
| Hum Mol Genet. 2008 Dec 15;17(24):3864-75. Epub 2008 Sep 9.
DOI Direct Link |
Novel STAT3 target genes exert distinct roles in the inhibition of mesoderm and endoderm differentiation in cooperation with Nanog.
Leukemia inhibitory factor (LIF) activates the transcription factor signal... | 23rd June, 2009
| Institut National de la Sante et de la Recherche Medicale, U846, Bron,
| Stem Cells. 2009 Aug;27(8):1760-71.
DOI Direct Link |
→View more research publications. |
IER3 results (if any) from reagent suppliers | 
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IEX-1 Antibody a stress inducible gene that is induced by ionizing ...
Additional Names. IEX-1, Immediate early response 3, IER3, DIF2, PRG1, GLY96. IEX-1 Antibody. Description. Left: Western blot analysis of IEX1 in human ...
http://www.prosci-inc.com/shop/catalog1/IEX-1-Antibody-p-654...
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IEX-1 (M-20) Antibody sc-8457
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Ier3, 15937, 17 B1, P46694 ...
http://www.scbt.com/datasheet-8457-iex-1-m-20-antibody.html...
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Accurate Chemical supplier of Antibodies, Monoclonal Antibodies ...
IER3, Rabbit anti-; paraffin,WB, purified, 50 µg. $444.00. BMDV10335, I-FLICE ( Inhibitor of FLICE), CASPAR, , cFLIP, FLAME-1, CASH, CLARP, 25-58kD, ...
http://www.accuratechemical.com/browse.asp?LETTER=I...
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IEX-1 (C-20) Antibody sc-8454
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, IER3, 8870, 6p21.33, NM_003897, ...
http://www.scbt.com/datasheet-8454-iex-1-c-20-antibody.html...
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The inaugural meeting Stem Cells 2006: Mexican Riviera Cancun ...
hypoxia, including Ak4, Akt3, Col X, Fmod, Ier3, IGFbp4, MafF, Mxi1, Rcor2, Rras , Sox6,. Tnni2, Wnt5a, and Zfp313. Page 141. Yunfei Zhou. Abstract P89 ...
http://www.abcam.com/ps/pdf/stemcells/stemcells06_programme....
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