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NAE1

Symbol:	NAE1
Name(s):	NEDD8 activating enzyme E1 subunit 1
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	A-116A10.1, APPBP1, HPP1, ula-1
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
12740388	Conservation in the mechanism of Nedd8 activation by the human AppBp1-Uba3 heterodimer.
12646924	structure and mutational analysis of human APPBP1-UBA3, the heterodimeric E1 enzyme for NEDD8
14690597	Data report the structure of the quaternary complex between human APPBP1-UBA3, a heterodimeric E1, its ubl NEDD8, and ATP.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	amyloid beta A4 protein precursor, isoform a	NEDD8 activating enzyme E1 subunit 1 isoform a	-	-	Pubmed
HPRD	amyloid beta A4 protein precursor, isoform a	NEDD8 activating enzyme E1 subunit 1 isoform a	-	-	Pubmed
BIND	amyloid beta A4 protein precursor, isoform a	NEDD8 activating enzyme E1 subunit 1 isoform a	The carboxy terminus of Amyloid Precursor Protein (APP) mediates an interaction with APP-BP1.	-	Pubmed
BIND	tumor protein p53 binding protein, 2 isoform 2	NEDD8 activating enzyme E1 subunit 1 isoform a	ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis	-	Pubmed
BIND	NEDD8 activating enzyme E1 subunit 1 isoform a	Homo sapiens UBA3 mRNA, complete cds.	APP-BP1 interaction with hUba3 is necessary to drive cell cycle through S-M checkpoint	-	Pubmed
HPRD	NEDD8 activating enzyme E1 subunit 1 isoform a	ubiquitin-activating enzyme E1C	-	-	Pubmed
HPRD	NEDD8 activating enzyme E1 subunit 1 isoform a	ubiquitin-activating enzyme E1C	-	-	Pubmed

Recent Publications on NAE1:
An evaluation of single nucleotide polymorphisms used to differentiate vaccine and wild type strains of varicella-zoster virus. Rashes following immunization with the vaccine strain (vOka) of...	4th March, 2005	Skin Virus Laboratory, Institute of Cell and Molecular Medicine, 25-29	J Med Virol. 2005 Jan;75(1):174-80. DOI Direct Link

Patents:
US Patent No.	Title
7300778	Human proteins responsible for NEDD8 activation and conjugation
5641660	Glutamicum threonine biosynthetic pathway
5681562	Lymphokine gene therapy of cancer
5723129	GnRH-leukotoxin chimeras
5736331	Method for identifying nucleic acids encoding c-fos promoter activating proteins
→View more patents.

NAE1 results (if any) from reagent suppliers

NAE1 (APPBP1) Antibody (C-term) HPP1; ula-1; NAE1; A-116A10.1; NEDD8-activating enzyme E1 regulatory subunit; ... NAE1 (APPBP1) Antibody (C-term). Western blot analysis of APPBP1 (arrow) ... http://www.abgent.com/products/catalog_no/AP7273e_NAE1_APPBP...
APPBP1 (20) Antibody sc-135839 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, NAE1, 8883, 16q22.1, Q13564 ... http://www.scbt.com/datasheet-135839-appbp1-20-antibody.html...
NAE1 (APPBP1) Antibody (C-term) HPP1; ula-1; NAE1; A-116A10.1; NEDD8-activating enzyme E1 regulatory subunit; Amyloid protein-binding protein 1;Amyloid beta precursor protein-binding ... http://www.abgent.com/products/catalog_no/AP7273b_NAE1_APPBP...
APPBP1 (20) Antibody sc-135839 人类, NAE1, 8883, 16q22.1, Q13564 · 603385. 小鼠, Nae1, 234664, 8 D3, Q8VBW6, N/ A. 订购信息. 产品名称, 产品编号, 规格, 价格, 数量, 欲购列单 ... http://www.scbt.com/zh/datasheet-135839-appbp1-20-antibody.h...
Protein Modification - Ubiquitination Antibody AP7273b, NAE1 (APPBP1) Antibody (C-term), WB, IHC, E, H. AP7273e, NAE1 (APPBP1) Antibody (C-term), WB, IHC, E, H. AP1070b, NCE2 Antibody (C-term E170) ... http://www.abgent.com/products/category/protein_modification...

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