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CCNA1


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Gene DB Home
Symbol:CCNA1
Name(s):cyclin A1
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17530187 Over expression of H179Y-mutant p53 promoted G1 to S phase transition with enlarged cell size and increased cyclin A1 and Cdk4 expression in HELF cells.
17455244 these analyses demonstrate that cyclin A1 exerts antiapoptotic functions by interacting with retinoblastoma and Ku proteins in leukemia cells.
16799873 The data implicate cyclin A1 as a downstream player in p53-dependent apoptosis and G2 arrest.
16007189 cyclin A1 mediates VEGF expression in cooperation with Rb- and androgen-dependent pathways in prostate cancer
15159402 study provides evidence that the cyclin A1-cyclin dependent kinase 2 complex plays a role in several signaling pathways important for cell cycle control and meiosis
12579332 CCNA1 had successive increases in its promoter activity during spermatgogensis in transgenic mice.
16449996 Significant tumour specific methylation of cyclin A1 promoter seen in oral sqmaous cell carcinoma
15342377 Cyclin A1 methylation was inversely related to p53 mutational status in primary tumors, and forced expression of cyclin A1 resulted in robust induction of wild-type p53 in HNSCC cell lines.
15456866 These findings establish a novel function for cyclin A1 and CDK2 in DNA double strand break repair following radiation damage.
12121569 the level of cyclin A1 mRNA expression predicts meiotic disorders during spermatogenesis

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDbreast cancer 1, early onset isoform 1cyclin A1 isoform aBRCA1 associates with Cyclin A-Pubmed
HPRDCDC2cyclin A1 isoform a--Pubmed
HPRDcell division cycle 2 protein isoform 1Cyclin A1--Pubmed
BINDcell division cycle 2 protein isoform 1cyclin A1 isoform aCCNA1 (CYCA) interacts with CDC2.-Pubmed
HPRDCDC 25Acyclin A1 isoform a--Pubmed
HPRDcell division cycle 25ACyclin A1--Pubmed
HPRDcell division cycle 25A isoform aCyclin A1--Pubmed
BIND-cyclin A1 isoform aCCNA1 (CYCA) interacts with unspecified isoform of CDK2.-Pubmed
HPRDcyclin-dependent kinase 2 isoform 1cyclin A1 isoform a--Pubmed
HPRDcyclin-dependent kinase 2 isoform 1cyclin A1 isoform a--Pubmed

Recent Publications on CCNA1:

Pubmed Logo
Methylation Markers for CCNA1 and C13ORF18 Are Strongly Associated with High-Grade Cervical Intraepithelial Neoplasia and Cervical Cancer in Cervical Scrapings.
PURPOSE: Recently, we reported 13 possible cervical cancer-specific...
22nd October, 2009
Departments of 1Gynecologic Oncology and 2Pathology, University Medical Cancer Epidemiol Biomarkers Prev. 2009 Oct 20.
DOI Direct Link
TGFbetaR2 aberrant methylation is a potential prognostic marker and therapeutic target in multiple myeloma.
Multiple myeloma (MM) is an incurable hematological malignancy. Different...
22nd September, 2009
Discipline of Hematology and Hemotherapy, Universidade Federal de Sao Int J Cancer. 2009 Oct 15;125(8):1985-91.
DOI Direct Link
Mutant p53 and cyclin A1 protein expression in primary laryngeal squamous cell carcinomas do not correlate to second primary tumours of the head and neck.
BACKGROUND: Field cancerization is a feature of head and neck squamous...
9th May, 2009
St Vincent's Hospital, Melbourne, Victoria, Australia. ANZ J Surg. 2009 Jan-Feb;79(1-2):48-54.
DOI Direct Link
Cyclin and protamine as prognostic molecular marker for testicular sperm extraction in patients with azoospermia.
The CCNA1, CCNB1, CCNB2, PRM1, and PRM2 messenger RNA transcript ratios...
28th April, 2009
Department of Organs Therapeutics, Division of Urology, Faculty of Fertil Steril. 2009 Apr;91(4 Suppl):1424-6. Epub 2008 Aug 9.
DOI Direct Link
Cyclin A1 regulates WT1 expression in acute myeloid leukemia cells.
Cyclin A1 is a cell cycle protein that is expressed in testes, brain and...
25th February, 2009
Department of Medicine, Hematology and Oncology, University Hospital of Int J Oncol. 2009 Jan;34(1):129-36.

View more research publications.

Clinical Trials:

Clinical Trials Logo
Identification of Predictive Markers for Testis Cancer in a Population of Men With High Risk

Patents:

Patents logo
US Patent No.Title
7612181 Dual variable domain immunoglobulin and uses thereof
7485418 Aberrantly methylated genes in pancreatic cancer
7341552 Gene sets for glioma classification
7338758 Compositions and methods for the identification, assessment, prevention and therapy of human cancers
6706867 DNA array sequence selection

View more patents.

CCNA1 results (if any) from reagent suppliers

Google CSE Logo
cyclin A1 (H-230) Antibody sc-15383
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CCNA1, 8900, 13q13.3, NM_003914 ...
http://www.scbt.com/datasheet-15383-cyclin-a1-h-230-antibody...

Thumbshot
CCNE1 antibody, Rabbit anti Cyclin E Antibody, Rabbit Polyclonal ...
Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Subcellular Location: Nucleus. ...
http://www.genwaybio.com/product_info.php?products_id=244482...

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cyclin A1 (H-230) Antibody sc-15383
Spezies, Gen, Gen ID, Chromosomaler Locus, mRNA (Isoform) Accession #, Protein Accession #, OMIM™ Nummer. Human, CCNA1, 8900, 13q13.3, NM_003914 · P78396 ...
http://www.scbt.com/de/datasheet-15383-cyclin-a1-h-230-antib...

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cyclin A1 (H-230) Antibody sc-15383
Species, 遺伝子名, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. ヒト, CCNA1, 8900, 13q13.3, NM_003914 ...
http://www.scbt.com/ja/datasheet-15383-cyclin-a1-h-230-antib...

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cyclin A1 (H-230) Antibody sc-15383
Humain, CCNA1, 8900, 13q13.3, NM_003914 · P78396 · 604036. Souris, Ccna1, 12427, 3 C, Q61456, Non disponible. Produits disponibles ...
http://www.scbt.com/fr/datasheet-15383-cyclin-a1-h-230-antib...

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