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BCL10


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Symbol:BCL10
Name(s):B-cell CLL/lymphoma 10
Type:protein-coding
Organism:Homo sapiens
Synonyms:CARMEN, CIPER, CLAP, c-E10, mE10
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
14674990 Nuclear expression of BCL10 is unlikely to correlate with the API2-MALT1 fusion gene in ocular adnexal MALT lymphoma.
16229939 Observational study of gene-disease association. (HuGE Navigator)
17893875 Epo has a role in reducing expression of apoptosis-related proteins Bcl-2 and Bcl-10 in ovarian cancer cells
17540779 Identify Bcl10 as a mediator of LPS-induced activation of NK-kappaB and IL-8.
16831874 Data show that IRAK-1 acts as the essential upstream adaptor that recruits BCL10 to the TLR4 signaling complex and mediates signaling to NF-kappaB through the BCL10-MALT1-TRAF6-TAK1 cascade.
15878976 The ability of Bcl10 expression to prevent B-cell antigen receptor-induced growth arrest and apoptosis of WEHI-231 cells was dependent on NF-kappaB activation.
15637807 BinCard inhibits BCL10-mediated activation of NF-kappa B.
11830492 vimplicated in apoptosis, and it has been suggested that mutated forms gain oncogenic activity. The occurrence of genomic BCL10 mutations in gastric MALT-type lymphomas was investigated.
17199743 BCL10 nuclear expression was present in four of 17 cases od MALT lymphoma.
17502353 These findings demonstrate that phosphorylation of Bcl10 at S138 down-regulates Bcl10 protein levels and thus negatively regulates T-cell receptor-mediated NF-kappaB activation.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcaspase 9 isoform alpha preproproteinBCL10--Pubmed
HPRDIKK alphaB-cell CLL/lymphoma 10--Pubmed
HPRDconserved helix-loop-helix ubiquitous kinaseBCL10--Pubmed
HPRDTRAF2B-cell CLL/lymphoma 10--Pubmed
HPRDTNF receptor-associated factor 2BCL10--Pubmed
BINDubiquitin-conjugating enzyme E2NB-cell CLL/lymphoma 10Bcl10 interacts with UBC13.-Pubmed
BINDubiquitin-conjugating enzyme E2 variant 2B-cell CLL/lymphoma 10Bcl10 interacts with MMS2.-Pubmed
BINDinhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gammaB-cell CLL/lymphoma 10Bcl10 interacts with NEMO.-Pubmed
HPRDTRADDB-cell CLL/lymphoma 10--Pubmed
HPRDTNFRSF1A-associated via death domainBCL10--Pubmed

Recent Publications on BCL10:

Pubmed Logo
Carrageenan-induced innate immune response is modified by enzymes that hydrolyze distinct galactosidic bonds.
The common food additive carrageenan (CGN) predictably induces intestinal...
30th October, 2009
Department of Medicine, University of Illinois at Chicago, Chicago, IL, J Nutr Biochem. 2009 Oct 27.
DOI Direct Link
[Crucial roles of Helicobacter pylori infection in the pathogenesis of gastric cancer and gastric mucosa-associated lymphoid tissue (MALT) lymphoma]
Helicobacter pylori (H. pylori) is a gram-negative helical rod that...
29th October, 2009
Department of Biomedical Laboratory Sciences, School of Health Sciences, Rinsho Byori. 2009 Sep;57(9):861-9.
Inhibition of MALT1 protease activity is selectively toxic for activated B cell-like diffuse large B cell lymphoma cells.
Diffuse large B cell lymphoma (DLBCL) is the most common type of lymphoma...
21st October, 2009
Third Medical Department, Technical University of Munich, Klinikum rechts J Exp Med. 2009 Oct 26;206(11):2313-20. Epub 2009 Oct 19.
DOI Direct Link
Mechanisms of NKT cell anergy induction involve Cbl-b-promoted monoubiquitination of CARMA1.
Repeated injection of alpha-galactosylceramide, an agonistic ligand for...
10th October, 2009
La Jolla Institute for Allergy and Immunology, La Jolla, CA 92037, USA. Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17847-51. Epub 2009 Oct 7.
DOI Direct Link
[A clinical study of chromosome translocations in extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue in Chinese patients]
OBJECTIVE: To investigate the genetic aberrations in extranodal marginal...
2nd October, 2009
Department of Pathology, Health Science Center, Peking University, Beijing Zhonghua Nei Ke Za Zhi. 2009 Mar;48(3):181-5.

View more research publications.

Clinical Trials:

Clinical Trials Logo
Prospective Study of First-Line Antibiotic Therapy for Early-Stage Gastric MALT Lymphoma for Treatment Outcome

Patents:

Patents logo
US Patent No.Title
7588771 Microorganisms for therapy
6756196 Molecules of the card-related protein family and uses thereof
6911306 TMS1 compositions and methods of use
6936690 Molecules of the card-related protein family and uses thereof
6953691 Nucleic acid molecule encoding a PANG6 polypeptide

View more patents.

BCL10 results (if any) from reagent suppliers

Google CSE Logo
Bcl10 antibody [151] (ab10432) | Abcam
Mouse monoclonal [151] to Bcl10. Bcl10 / CIPER/ CLAP / mE10 is expressed in many human and murine tissues. It contains a CARD (caspase recruiting domain) ...
http://www.abcam.com/bcl10-antibody-151-ab10432.html...

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Anti-BCL-10 Polyclonal Antibody
Polyclonal Antibody against BCL-10 for use in Western Blot.
http://www.bioreagents.com/products/productDetails/productDe...

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Bcl10 (331.3) Antibody sc-5273
See how others have used Bcl10 (331.3): sc-5273 antibody and or Bcl10 (331.3) ... Phosphorylation of Bcl10 Negatively Regulates T-Cell Receptor-Mediated ...
http://www.scbt.com/datasheet-5273-bcl10-331-3-antibody.html...

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Purified Anti-Bcl10 Antibody - BioLegend
Purified Anti-Bcl10 Antibody - BCL10 promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. It may be an adapter
protein ...
http://www.biolegend.com/purified-anti-bcl10-antibody-5122.h...

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p-Bcl10 (6D3) Antibody sc-81484
Bcl10 shRNA (h) Lentiviral Particles, sc-29793-V, 200 µl ... Western blot analysis of Bcl10 phosphorylation in non-transfected: sc-117752 (A) and mouse
...
http://www.scbt.com/datasheet-81484-p-bcl10-6d3-antibody.htm...

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Bcl-10 Antibody (NT) Involved in apoptosis and tumor
Bcl-10 antibody can be used for detection of BCL10 by Western blot at 1:500 dilution. An approximately 31 kDa band can be detected. ,
http://www.prosci-inc.com/shop/catalog1/Bcl-10-Antibody-p-60...

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Bcl10 (C-17) Antibody sc-9560
See how others have used Bcl10 (C-17): sc-9560 antibody and or Bcl10 (C-17) ... Western blot analysis of Bcl10 expression in non-transfected: sc-117752 (A) ...
http://www.scbt.com/datasheet-9560-bcl10-c-17-antibody.html...

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Data show that IRAK-1 acts as the essential upstream adaptor that recruits BCL10 to the TLR4 signaling complex and mediates signaling to NF-kappaB through the BCL10-MALT1-TRAF6-TAK1 cascade. | cll findings 2009 | lymphoma 10 | lymphoma 10 | lymphoma 10 | H PYLORI AND CLL NEW FINDINGS 2009 | p-bcl10 antibody | CLL 2009 | dectin-1 B-cell | .


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