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WASF1


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Symbol:WASF1
Name(s):WAS protein family, member 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:FLJ31482, KIAA0269, SCAR1, WAVE, WAVE1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17696648 the Hem-1/Nap1 component of the Scar/WAVE complex localizes to propagating waves that appear to organize the leading edge of a motile neutrophil
17901257 WAVE1 is critical for formation of oligodendrocyte lamellae and myelin sheaths--REVIEW
12429845 Results suggest that recruitment of factors by Wiskott-Aldrich Syndrome protein (WASP) and Scar1 stimulates cellular actin-based motility and actin nucleation with the Arp2/3 complex.
15506982 Dictyostelium discoideum has been used to remove genetically SCAR complex members to ascertain their specific roles.
12181570 Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck: we propose that Rac1 and Nck cause dissociation of the WAVE1 complex, which releases active WAVE1-HSPC300 and leads to actin nucleation.
12855698 WAVE1 may act as a scaffold to recruit the NADPH oxidase to a complex involved with both cytoskeletal regulation and downstream JNK activation
15280206 the 3 WAVE isoforms exhibit common and distinct features and may potentially be involved in the regulation of actin cytoskeleton in platelets
15670045 WAVE-1 expression was associated with megakaryocytic differentiation; WAVE-1 and WAVE-2 moved from a detergent-soluble cytosolic fraction to insoluble cytoskeleton fraction after platelet aggregation
17101133 NESH (Abi-3), like Abi-1 and Abi-2, is a component of the Abi/WAVE complex, but likely plays a different role in the regulation of c-Abl.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDv-abl Abelson murine leukemia viral oncogene homolog 1 isoform aWiskott-Aldrich syndrome protein family member 1--Pubmed
BINDv-abl Abelson murine leukemia viral oncogene homolog 1 isoform bWiskott-Aldrich syndrome protein family member 1WAVE-1 interacts with Abl.-Pubmed
BINDactin, gamma 1 propeptideWiskott-Aldrich syndrome protein family member 1WAVE-1 interacts with G-actin. This interaction was modeled on a demonstrated interaction between human WAVE-1 and rat G-actin.-Pubmed
HPRDCDC42Wiskott-Aldrich syndrome protein family member 1--Pubmed
HPRDcell division cycle 42 isoform 1WAVE1--Pubmed
HPRDFynWiskott-Aldrich syndrome protein family member 1--Pubmed
HPRDprotein-tyrosine kinase fyn isoform aWAVE1--Pubmed
HPRDGrb2Wiskott-Aldrich syndrome protein family member 1--Pubmed
HPRDgrowth factor receptor-bound protein 2 isoform 1WAVE1--Pubmed
HPRDprofilin 1Wiskott-Aldrich syndrome protein family member 1--Pubmed

Recent Publications on WASF1:

Pubmed Logo
WASP and SCAR/WAVE proteins: the drivers of actin assembly.
Neurofibromatosis type 1 (NF1) is a common disorder that arises secondary...
17th October, 2009
Centre for Cardiovascular Sciences, Institute of Biomedical Research, J Cell Sci. 2009 Aug 1;122(Pt 15):2575-8.
DOI Direct Link
Glomus tumors in neurofibromatosis type 1: genetic, functional, and clinical evidence of a novel association.
Neurofibromatosis type 1 (NF1) is a common disorder that arises secondary...
8th October, 2009
Department of Human Genetics, Catholic University Leuven, Leuven, Belgium. Cancer Res. 2009 Sep 15;69(18):7393-401. Epub 2009 Sep 8.
DOI Direct Link
[Role of WAVE1 in drug resistance of K562/A02 leukemia cells]
OBJECTIVE: To investigate if WAVE1 is involved in mult drug-resistance...
1st October, 2009
Department of Pediatrics, Xiangya Hospital, Central South University, Zhonghua Xue Ye Xue Za Zhi. 2007 Jun;28(6):379-82.
[Role of Cdk5 in dopamine signaling and addiction]
Neurofibromatosis type 1 (NF1) is a common disorder that arises secondary...
6th August, 2009
Tanpakushitsu Kakusan Koso. 2009 Jun;54(7):813-9.
A translocated protein of Bartonella henselae interferes with endocytic uptake of individual bacteria and triggers uptake of large bacterial aggregates via the invasome.
Bartonella henselae enters human endothelial cells (ECs) by two...
6th August, 2009
Focal Area Infection Biology, Biozentrum of the University of Basel, Cell Microbiol. 2009 Jun;11(6):927-45. Epub 2009 Feb 27.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods

WASF1 results (if any) from reagent suppliers

Google CSE Logo
ORDERING INFORMATION
3 Mar 2009 ... aa 1 - 250, human WASF1/WAVE1 shares 99% aa identity with mouse WASF1/WAVE1. ... This antibody detects endogenous human/mouse WASF1/WAVE1 in ...
http://www.rndsystems.com/pdf/AF5514.pdf...

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WAVE1 (L-19) Antibody sc-10388
Human, WASF1, 8936, 6q21, NM_001024934, NM_001024935, NM_001024936, NM_003931 · Q92558 · 605035. Mouse, Wasf1, 83767, 10 B1, Q8R5H6 ...
http://www.scbt.com/datasheet-10388-wave1-l-19-antibody.html...

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WASF1/WAVE1 - R&D Systems
WASF1/WAVE1. Members of the WASP family play important roles in actin remodeling and reorganization that control cell morphology, cell shape change, ...
http://www.rndsystems.com/molecule_detail.aspx?m=4273...

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WAVE1 (30) Antibody sc-136120
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, WASF1, 8936, 6q21, Q92558 ...
http://www.scbt.com/datasheet-136120-wave1-30-antibody.html...

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Search Results
Stock# - 007446 Strain name - B6.129X1-Wasf1/J JAX® Mice Database Site Section: JAX® Mice and services · jaxmice.jax.org/strain/007446.html - 26Kb ...
http://www.jax.org/search/Main.jsp?sg=0&qt=platform&page=7...

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June 09 NPR non-priced.indd
WASF1/WAVE1. Human/Mouse. Goat IgG. AF5514. 100 µg. WASF3/WAVE3. Human/Mouse. Goat IgG. AF5515. 100 µg. ZIC3. Human/Mouse. Sheep IgG ...
http://www.rndsystems.com/DAM_public/6399.pdf...

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Search Results
Stock# - 007445 Strain name - B6.129X1-Wasf1/J JAX® Mice Database Site Section: JAX® Mice and services · jaxmice.jax.org/strain/007445.html - 31Kb ...
http://www.jax.org/search/Main.jsp?sg=4&qt=platform&page=6...

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