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CCND2

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Symbol:	CCND2
Name(s):	cyclin D2
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	KIAK0002, MGC102758
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18281541	Observational study of gene-disease association. (HuGE Navigator)
17873913	Responsible for neoplastic cell transformation when coexpressed with an activated Ras protein.
17882269	role for D-type cyclins in the excessive basal-cell proliferation and perturbed keratinocyte differentiation in the psoriatic epidermis
17409409	Observational study of gene-disease association. (HuGE Navigator)
18174243	Observational study of gene-disease association. (HuGE Navigator)
17486076	cyclin D2 expression in normal and malignant hematopoietic cells is regulated by ubiquitin/proteasome-dependent degradation triggered by Thr280 phosphorylation by GSK3beta or p38, which is induced by inhibition of the PI3K pathway
12777997	results show that cyclin D2 is complexed with p27, leading to a model for testicular germ cell tumors whereby the overexpression of cyclin D2 leads to the functional sequestration of p27 in the presence of CCNE and CCND2, favoring cell proliferation
14612939	DNA hypomethylation is a mechanism underlying the increased expression of cyclin D2 in cancer cells and demethylation of cyclin D2 may be involved in development and progression of gastric carcinoma
15245432	E2 may stimulate the growth of keratinocytes by inducing cyclin D2 expression via CREB phosphorylation by protein kinase A, dependent on cAMP.
15755896	Cyclin D1, D2, or D3 expression appears to be increased and/or dysregulated in virtually all MM tumors despite their low proliferative capacity
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
BIND	B-cell lymphoma 6 protein	Homo sapiens chromosome 12	BCL6 interacts with the CCND2 promoter region.	-	Pubmed
HPRD	Cyclin D2	A-kinase anchor protein 8	-	-	Pubmed
HPRD	Cyclin D2	cyclin D binding myb-like transcription factor 1	-	-	Pubmed
BIND	Homo sapiens chromosome 12	signal transducer and activator of transcription 5A	STAT5A interacts with Cyclin D2 promoter.	-	Pubmed
BIND	Homo sapiens chromosome 12	nuclear receptor co-repressor 1	NcoR interacts with the CCND2 promoter region.	-	Pubmed
BIND	Homo sapiens chromosome 12	nuclear receptor co-repressor 2	SMRT interacts with the CCND2 promoter region.	-	Pubmed
HPRD	cyclin D2	Cyclin dependent kinase 4	-	-	Pubmed
HPRD	cyclin D2	AKAP95	-	-	Pubmed
BIND	cyclin D2	cyclin-dependent kinase 4	CCND2 interacts with CDK4	-	Pubmed
HPRD	cyclin D2	cyclin-dependent kinase 4	-	-	Pubmed

Recent Publications on CCND2:
Di-(2-ethylhexyl) phthalate and Mono-(2-ethylhexyl) phthalate Inhibit Growth and Reduce Estradiol Levels of Antral Follicles In Vitro. Any insult that affects survival of ovarian antral follicles can cause...	31st October, 2009	Division of Toxicology, Department of Veterinary Biosciences, University	Toxicol Appl Pharmacol. 2009 Oct 26. DOI Direct Link
Association between Lifestyle Factors and CpG Island Methylation in a Cancer-Free Population. BACKGROUND: Many risk factors have been associated with cancer, such as...	29th October, 2009	Departments of 1Otolaryngology-Head and Neck Surgery and 2Oncology, Johns	Cancer Epidemiol Biomarkers Prev. 2009 Oct 27. DOI Direct Link
Hedgehog target genes: mechanisms of carcinogenesis induced by aberrant hedgehog signaling activation. Hedgehog signaling is aberrantly activated in glioma, medulloblastoma,...	29th October, 2009	M & M Medical Bioinformatics, Hongo 113-0033, Japan.	Curr Mol Med. 2009 Sep;9(7):873-86.
Identification of novel gene amplifications in breast cancer and coexistence of gene amplification with an activating mutation of PIK3CA. To identify genetic events that characterize cancer progression, we...	8th October, 2009	Laboratory of Population Genetics, Center for Cancer Research, National	Cancer Res. 2009 Sep 15;69(18):7357-65. Epub 2009 Aug 25. DOI Direct Link
Stem cell regulatory gene expression in human adult dental pulp and periodontal ligament cells undergoing odontogenic/osteogenic differentiation. INTRODUCTION: During development and regeneration, odontogenesis and...	6th October, 2009	Department of Operative Dentistry, Guanghua School of Stomatology, Sun	J Endod. 2009 Oct;35(10):1368-76. Epub 2009 Aug 28. DOI Direct Link
→View more research publications.

Clinical Trials:
Simvastatin in Preventing a New Breast Cancer in Women Who Are at High Risk for a New Breast Cancer After Undergoing Surgery for Ductal Carcinoma in Situ or Stage I, Stage II, or Stage III Breast Cancer

Patents:
US Patent No.	Title
7598031	Method for the detection of gene transcripts in blood and uses thereof
7091033	Array of toxicologically relevant canine genes and uses thereof
7045292	Method and marker for identification of pre-malignancy and malignancy and therapeutic intervention
7026121	Methods and compositions for diagnosing and monitoring transplant rejection
6905827	Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
→View more patents.

CCND2 results (if any) from reagent suppliers

cyclin D2 (DCS-3) Antibody sc-56305 Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, CCND2, 894, 12p13.32, NM_001759 ... http://www.scbt.com/datasheet-56305-cyclin-d2-dcs-3-antibody...
C7339 Monoclonal Anti-Cyclin D2 antibody produced in mouse clone ... microarray: suitable. isotype, IgG2a. Gene Information, human ... CCND2(894). mouse ... Ccnd2(12444). shipped in, dry ice. storage temp. −20°C ... http://www.sigmaaldrich.com/catalog/ProductDetail.do?D7=0&N5...
Abgent - Phosphorylation Antibodies - Phosphorylation AP7292b, CCNA2 Antibody (C-term), WB, IHC, E, H. AT1419a, CCND2 monoclonal antibody (M01), ELISA,WB-Re,WB-Tr, H. AT1420a, CCNG1 monoclonal antibody (M01) ... http://www.abgent.com/products/category/protein_modification...
Antibodies to Cyclins and CDKs Ccnd2(12444), mouse, human, ARR, ELISA (i), FACS, ICC, IP, WB, pricing. P7962, Monoclonal Anti-PSTAIR antibody produced in mouse, PSTAIR (monoclonal) ... http://www.sigmaaldrich.com/etc/controller/controller-page.h...
cyclin D1 (M-20) Antibody sc-718 Mouse, Ccnd2, 12444, 6 F3, P30280, N/A. Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List. cyclin D1 (M-20), sc-718, 200 µg/ml ... http://www.scbt.com/datasheet-718-cyclin-d1-m-20-antibody.ht...
Panorama® Antibody Array - Signal Transduction caspase 9, apoptosis-related cysteine protease. 842 · CCNB1. cyclin B1. 891 · CCND1. cyclin D1 (PRAD1: parathyroid adenomatosis 1). 595 · CCND2. cyclin D2 ... http://www.sigmaaldrich.com/life-science/cell-biology/protei...
Abgent - Cancer Antibodies - Cancer AP2612a, CCND1 Antibody (N-term), WB, E, H. AT1419aNEW, CCND2 monoclonal antibody (M01), ELISA,WB-Re,WB-Tr, H. AP6270cNEW, CCNE1 Antibody (Center), WB, E , H ... http://www.abgent.com/products/category/cell_function/cancer...

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CCND2

Gene Information from Publications

Interacting gene products

Recent Publications on CCND2:

Clinical Trials:

Patents:

CCND2 results (if any) from reagent suppliers