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P4HA2


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Symbol:P4HA2
Name(s):procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide II
Type:protein-coding
Organism:Homo sapiens
Synonyms:-
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17213842 Observational study of gene-disease association. (HuGE Navigator)
16877351 In comparison with healthy cartilage, Osteoarthritis articular chondrocytes exhibit increased in vivo synthesis of collagen prolyl-4-hydroxylase type II, a pivotal enzyme in collagen triple helix formation.
16885164 HIF-P4H, HIF-1alpha and HIF-2alpha are effective oxygen sensors
16917063 results show that p53 transcriptionally activates the alpha(II) collagen prolyl-4-hydroxylase [alpha(II)PH] gene, resulting in the extracellular release of antiangiogenic fragments of collagen type 4 and 18
12824157 the substrate specificity, binding site and conformation of this enzyme

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDProtein disulfide isomeraseprolyl 4-hydroxylase, alpha II subunit isoform 1 precursor--Pubmed
HPRDHLA-B associated transcript-2 isoform aprolyl 4-hydroxylase, alpha II subunit isoform 1 precursor--Pubmed

Recent Publications on P4HA2:

Pubmed Logo
Activation of hypoxia-inducible factor-1 via prolyl-4 hydoxylase-2 gene silencing attenuates acute inflammatory responses in postischemic myocardium.
Emerging research suggests that oxidant-driven transcription of key...
20th October, 2007
Division of Pulmonary and Critical Care Medicine, Department of Internal Am J Physiol Heart Circ Physiol. 2007 Sep;293(3):H1571-80. Epub 2007 Jun
DOI Direct Link
Refined genomic localization and ethnic differences observed for the IBD5 association with Crohn's disease.
Although the general association of the inflammatory bowel disease (IBD) 5...
19th April, 2007
Department of Medicine, Mount Sinai Hospital IBD Centre, University of Eur J Hum Genet. 2007 Mar;15(3):328-35. Epub 2007 Jan 10.
DOI Direct Link
Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen levels.
Osteoarthritic (OA) chondrocytes are metabolically active, displaying...
2nd September, 2006
Division of Orthopedic Rheumatology, Department of Orthopedic Surgery im Am J Pathol. 2006 Aug;169(2):491-502.
OCTNs: will the real IBD5 gene please stand up?
Crohn's disease and ulcerative colitis are inflammatory disorders of the...
15th August, 2006
Mount Sinai Hospital IBD Centre, Department of Medicine, Toronto, Ontario, World J Gastroenterol. 2006 Jun 21;12(23):3678-81.
Gene expression profile of papillary thyroid cancer: sources of variability and diagnostic implications.
The study looked for an optimal set of genes differentiating between...
5th April, 2005
Department of Nuclear Medicine and Endocrine Oncology, Maria Cancer Res. 2005 Feb 15;65(4):1587-97.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7531300 Method of diagnosing breast cancer
7442390 Method for enhancing engraftment of cells using mesenchymal progenitor cells
7251568 Methods and compositions for regulating bone and cartilage formation
7049072 Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
6706867 DNA array sequence selection

View more patents.

P4HA2 results (if any) from reagent suppliers

Google CSE Logo
P4HA Antibody / P4HA Antibodies
P4HA2 shRNA Plasmid (m): sc-151966-SH. P4HA2 shRNA (m) Lentiviral Particles: sc- 151966-V. P4HA3 siRNA (h): sc-97000. P4HA3 shRNA Plasmid (h): sc-97000-SH ...
http://www.scbt.com/table-p4ha.html...

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P4HA2 antibodies: Signal Transduction > Cytoskeleton / ECM ...
P4HA2 antibodies. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab70811 · P4HA2 antibody. IP. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=268454&pt=1&c=766&ei=&mu=r...

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P4HA2 siRNA (m) sc-151966
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: P4HA2 ...
http://www.scbt.com/ko/datasheet-151966-p4ha2-sirna-m.html...

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Abgent - Cancer Antibodies - Cancer
AP1080b, P300 (EP300) Antibody (C-term), E, H. AP1080a, P300 (EP300) Antibody ( Center), E, H. AP7393bNEW, P4HA2 Antibody (C-term), WB, E, H ...
http://www.abgent.com/products/category/cell_function/cancer...

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Abcam antibodies and reagents product map
... Ornithine Carbamoyltransferase antibodies (1) · Ornithine Decarboxylase antibodies (5) · P protein antibodies (1) · P4HA2 antibodies (2) ...
http://www.abcam.com/index.html?c=2105...

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Site Map Bethyl Laboratories
P4HA2 ...
http://www.bethyl.com/content/sitemap...

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