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WASL


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Symbol:WASL
Name(s):Wiskott-Aldrich syndrome-like
Type:protein-coding
Organism:Homo sapiens
Synonyms:DKFZp779G0847, MGC48327, N-WASP, NWASP
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18191793 These data constitute evidence that Toca-1 is required for N-WASP-mediated actin polymerization by Shigella flexneri in vivo.
17573773 CR16 and N-WASP are suggested to play important roles in spermatogenesis
16687395 Nef interferes with maturation of stimulatory T-lymphocyte contacts by modulation of N-Wasp activity
15102814 Expression of the WA fragment of N-WASP to block associated actin polymerization also inhibited C. parvum invasion.
15699051 NF2 tumor suppressor Merlin and the ERM proteins interact with N-WASP and regulate its actin polymerization function
16293614 WASP and N-WASP are activated and phosphorylated by protein-tyrosine kinase and GTPase signals
16885158 a vesicle trafficking regulator Toca-1 regulates different aspects of neuronal morphology from N-WASP
15169891 Erk phosphorylation liberates the SH3 domain of cortactin from intramolecular interactions with proline-rich regions, causing it to synergize with WASP and N-WASP in activating the Arp2/3 complex
16767080 We demonstrate that the interaction of N-WASP with the PSF-NonO complex can couple N-WASP with RNA polymerase II to regulate transcription.
17085436 signal-induced relief of the autoinhibited fold of IQGAP1 allows activation of N-WASP to stimulate Arp2/3-dependent actin assembly

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDcell division cycle 42 isoform 1Wiskott-Aldrich syndrome gene-like protein--Pubmed
HPRDcell division cycle 42 isoform 1Wiskott-Aldrich syndrome gene-like protein--Pubmed
HPRDcortactin isoform aNeural Wiskott Aldrich syndrome protein--Pubmed
HPRDgrowth factor receptor-bound protein 2 isoform 1Wiskott-Aldrich syndrome gene-like protein--Pubmed
HPRDgrowth factor receptor-bound protein 2 isoform 1Wiskott-Aldrich syndrome gene-like protein--Pubmed
BINDheat shock protein 90kDa alpha, class A member 1 isoform 2Wiskott-Aldrich syndrome gene-like proteinWASL (N-WASP) interacts with HSPCA (HSP90-alpha).-Pubmed
BINDheat shock 90kDa protein 1, betaWiskott-Aldrich syndrome gene-like proteinWASL (N-WASP) interacts with HSPCB (HSP90-beta).-Pubmed
HPRDNCK1Wiskott-Aldrich syndrome gene-like protein--Pubmed
HPRDNCK adaptor protein 1NWASP--Pubmed
HPRDProfilin 1Wiskott-Aldrich syndrome gene-like protein--Pubmed

Recent Publications on WASL:

Pubmed Logo
A survey of folic acid use in primigravid women.
A convenience sample of 320 consecutive primigravid women attending the...
16th October, 2009
Practice Development Midwife-Delivery Suite, Al Wasl Hospital, Dubai, Women Birth. 2009 Oct 12.
DOI Direct Link
cDNA microarray reveals the alterations of cytoskeleton-related genes in osteoblast under high magneto-gravitational environment.
The diamagnetic levitation as a novel ground-based model for simulating a...
22nd September, 2009
Key Laboratory for Space Bioscience and Biotechnology, Faculty of Life Acta Biochim Biophys Sin (Shanghai). 2009 Jul;41(7):561-77.
Molecular profiling to identify molecular mechanism in esophageal cancer with familial clustering.
To identify the genes and molecular functional pathways involved in...
12th August, 2009
Institute of Pathology, Safdarjung Hospital Campus, New Delhi-110029, Oncol Rep. 2009 May;21(5):1135-46.
The Toca-1-N-WASP complex links filopodial formation to endocytosis.
The transducer of Cdc42-dependent actin assembly (Toca-1)-N-WASP complex...
9th June, 2009
Institute of Medical Biology, 8A Biomedical Grove, Immunos, Singapore J Biol Chem. 2009 Apr 24;284(17):11622-36. Epub 2009 Feb 11.
DOI Direct Link
Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoA.
The molecular mechanisms underlying the elaboration of branched processes...
12th May, 2009
Montreal Neurological Institute, Department of Neurology and Neurosurgery, Development. 2009 Feb;136(3):415-26.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7550578 Rice promoters for regulation of plant expression
4839432 Method of manufacturing a grafted resin composition
5285504 Page segmentation with tilt compensation
6377562 Wireless asymmetric local loop (WASL) communication
6727063 Single nucleotide polymorphisms in genes

View more patents.

WASL results (if any) from reagent suppliers

Google CSE Logo
WASL monoclonal antibody (M04)
WASL (NP_003932, 97 a.a. ~ 185 a.a) partial recombinant protein with GST tag. ... Immunofluorescence of monoclonal antibody to WASL (AT4527a) on HeLa cell .
...
http://www.abgent.com/products/catalog_no/AT4527a_WASL_monoc...

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N-WASP (H-100) Antibody sc-20770
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, WASL, 8976, 7q31.32, NM_003941 ...
http://www.scbt.com/datasheet-20770-n-wasp-h-100-antibody.ht...

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Abgent - Cell and Structure Antibodies - Cell_structure
AT4526aNEW, WASF2 monoclonal antibody (M02), ELISA,S-ELISA,WB-Ce,WB-Re, H. AT4527aNEW, WASL monoclonal antibody (M04), ELISA,IF,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function/cell_s...

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PhosphoSignature™
WASL. Neural Wiskott-Aldrich syndrome protein (N-. WASP). O00401. 55. §256. VIyDFIEK. 2. 593. 1.0. 1.0-1.1. PAG1. Phosphoprotein associated with ...
http://www.cellsignal.com/technologies/phosphoscan/pdfs/PSig...

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