Monday November 23 2009 | Biotechnology feed | All feeds

CCNE1

Suggest Content
Advertise Here
Gene DB Home

Symbol:	CCNE1
Name(s):	cyclin E1
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	CCNE
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
18281541	Observational study of gene-disease association. (HuGE Navigator)
17409409	Observational study of gene-disease association. (HuGE Navigator)
18174243	Observational study of gene-disease association. (HuGE Navigator)
18047954	Tissue expression of cyclin D1 or E1 seems not to add independent prognostic value to standard features in patients with nonmuscle -invasive urothelial cell carcinoma of the bladder.
17664332	Data show that cyclin E overexpression impairs progression through mitosis by inhibiting APC(Cdh1).
17325036	Association of a fragment of cyclin E with Ku70 induces dissociation of Bax, its activation, and apoptosis. These interactions provide a balance between apoptosis and the survival of cells exposed to genotoxic stress.
16912169	HuR critically contributes to cyclin E1 overexpression and its growth-promoting function in breast cancer cells.
16740753	The CCNE1 qualify as independent prognostic markers for lymph node-negative breast cancer patients, and CCNE1 may provide additional information for specific subgroups of patients.
15800668	p16(INK4A) reconstitution in p16(INK4A)-deficient T-ALL cells induced cell cycle arrest in the presence of cyclin E and c-Myc expression, uncoupled growth from cell cycle progression and caused a sequential process of growth, differentiation and apoptosis
16504183	Cyclin-dependent kinases regulate the transcriptional activity of FOXM1c; a combination of three phosphorylation sites mediates the Cyclin E and Cyclin A/CDK2 effects.
→View more information from publications.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	androgen receptor isoform 1	cyclin E1 isoform 1	-	-	Pubmed
HPRD	androgen receptor isoform 1	cyclin E1 isoform 1	-	-	Pubmed
BIND	-	cyclin-dependent kinase inhibitor 1A	CDKN1A (p21) interacts with CCNE1 (cyclin E).	-	Pubmed
BIND	-	cyclin-dependent kinase inhibitor 1A	p21 interacts with cyclin E.	-	Pubmed
HPRD	Cyclin E1	cyclin-dependent kinase 3	-	-	Pubmed
HPRD	Cyclin E1	cyclin-dependent kinase 2 isoform 1	-	-	Pubmed
HPRD	Cyclin E1	retinoblastoma-like protein 1 isoform a	-	-	Pubmed
HPRD	Cyclin E1	SWI/SNF-related matrix-associated actin-dependent regulator of chromatin c1	-	-	Pubmed
BIND	-	cyclin-dependent kinase inhibitor 1B	p27 interacts with cyclin E.	-	Pubmed
BIND	-	cyclin-dependent kinase inhibitor 1B	p27 interacts with Cyc E.	-	Pubmed

Recent Publications on CCNE1:
Artemis regulates cell cycle recovery from the S phase checkpoint by promoting degradation of cyclin E. Artemis, a member of the SNM1 gene family, is a known phosphorylation...	29th October, 2009	Department of Oncology, First Affiliated Hospital, Zhejiang University	J Biol Chem. 2009 Jul 3;284(27):18236-43. Epub 2009 May 7. DOI Direct Link
Analysis of breast cancer related gene expression using natural splines and the Cox proportional hazard model to identify prognostic associations. Many studies correlating gene expression data to clinical parameters...	28th October, 2009	Divisions of Radiation Oncology and Experimental Therapy, The Netherlands	Breast Cancer Res Treat. 2009 Oct 27. DOI Direct Link
Identification of the gene encoding cyclin E1 (CCNE1) as a novel IGH translocation partner in t(14;19)(q32;q12) in diffuse large B-cell lymphoma. In a subset of B-cell malignancies, the genes encoding members of the...	14th October, 2009	Institute of Human Genetics, University Hospital Schleswig-Holstein,	Haematologica. 2009 Jul;94(7):1020-3. Epub 2009 May 19. DOI Direct Link
Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc. During estrogen-induced proliferation, c-Myc and cyclin D1 initiate...	6th October, 2009	Cancer Research Program, Garvan Institute of Medical Research, NSW,	Mol Cell Biol. 2009 Sep;29(17):4623-39. Epub 2009 Jun 29. DOI Direct Link
A quantitative comparison of wild-type and gatekeeper mutant cdk2 for chemical genetic studies with ATP analogues. Chemical genetic studies with enlarged ATP binding sites and unnatural ATP...	1st October, 2009	Division of Cell and Molecular Biology, Imperial College, London SW72AZ,	Chembiochem. 2009 Jun 15;10(9):1519-26. DOI Direct Link
→View more research publications.

Clinical Trials:
A Clinical Trial to Validate Molecular Targets of Vorinostat in Patients With Stage I-III Non-Small Cell Lung Cancer

Patents:
US Patent No.	Title
7612181	Dual variable domain immunoglobulin and uses thereof
6960439	Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6964850	Identification, monitoring and treatment of disease and characterization of biological condition using gene expression profiles
6979542	Methods for identifying heterozygous carriers of autosomal recessive diseases
7157233	Methods and compositions for the detection of cervical disease
→View more patents.

CCNE1 results (if any) from reagent suppliers

CCNE1 Antibody Specific antibody for the gene product of CCNE1, the protein Cyclin E1. Validated for specificity by gene-silencing with siRNA followed by Western blot ... http://www.piercenet.com/Products/browse.cfm?fldID=5FE6A27B-...
CCNE1 antibody, Rabbit anti Cyclin E Antibody, Rabbit Polyclonal ... Buy quality rabbit CCNE1 antibody (interacts with n/a), anti-CCNE1, Rabbit anti Cyclin E antibody, rabbit polyclonal antibody, Rabbit anti Cyclin E Antibody ... http://www.genwaybio.com/product_info.php?products_id=244482...
CDK2 + CCNE1 proteins and peptides: Cancer > Cell cycle > Kinases ... CDK2 + CCNE1 protein (Active). SDS-PAGE, WB, FuncS. Images · ab85836 · CDK2 + CCNE1 protein (Tagged). SDS-PAGE, WB. Images · Terms and conditions · Legal ... http://www.abcam.com/index.html?t=286843&pt=2&c=4212&ei=&mu=...
cyclin E (H-145) Antibody sc-20684 Human, CCNE1, 898, 19q12, NM_001238, NM_057182 · P24864 · 123837. Mouse, Ccne1, 12447, 7 B2, Q61457, N/A. Mouse, Ccne1, 12447, 7 B2, Q61457 ... http://www.scbt.com/datasheet-20684-cyclin-e-h-145-antibody....
Phospho-Cyclin E1-T395 Antibody G1/S-specific cyclin-E1; CCNE1; CCNE;. Application Data: Calculated MW: 47077 Da . Phospho-Cyclin E1-T395 Antibody. (LEFT) The anti-Phospho-Cyclin E1-T395 ... http://www.abgent.com/products/catalog_no/AP3081a_Phospho_Cy...
cyclin E (HE12) Antibody sc-247 CHROMOSOMAL LOCATION, Genetic locus: CCNE1 (human) mapping to 19q12; Ccne1 ( mouse) mapping to 7 B2.. SOURCE, cyclin E (HE12) is a mouse monoclonal antibody ... http://www.scbt.com/datasheet-247-cyclin-e-he12-antibody.htm...
Cyclin E1 Antibody (C-term) G1/S-specific cyclin-E1; CCNE1; CCNE. Application Data: Calculated MW: 47077 Da. Cyclin E1 Antibody (C-term). Western blot analysis of Cyclin E1 (C-term) ... http://www.abgent.com/products/catalog_no/AP6270b_Cyclin_E1_...

Resources from the NCBI used on this page, NCBI's standard disclaimer applies.

Nothing in this website should be used in place of personal medical advice from your own qualified medical practitioner.

CCNE1

Gene Information from Publications

Interacting gene products

Recent Publications on CCNE1:

Clinical Trials:

Patents:

CCNE1 results (if any) from reagent suppliers