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KALRN


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Symbol:KALRN
Name(s):kalirin, RhoGEF kinase
Type:protein-coding
Organism:Homo sapiens
Synonyms:DUET, FLJ16443, HAPIP, TRAD, duo
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18199770 Kalirin-7 is an essential component of both shaft and spine excitatory synapses in hippocampal interneurons.
17851188 Our observation is the first to relate kalirin to Alzheimer's disease. Kalirin was consistently under-expressed in Alzheimer's disease hippocampus.
17640372 ARF6 recruits KALRN to the cell membrane facilitating Rac activation.
14742910 we have identified multiple transcriptional start sites in rats and humans. These multiple transcriptional start sites result in full-length Kalirin transcripts possessing different 5' ends encoding proteins with differing amino termini
17357071 Three SNPs from the kalirin (KALRN) gene are associated with early-onset coronary artery disease.
15950621 Kalirin GEF1 domain induces lamellipodia through activation of Pak, where Guanine nucleotide exchange factor (GEF) activity is not required.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDPeptidylglycine alpha amidating monooxygenasekalirin, RhoGEF kinase isoform 2--Pubmed
BINDkalirin, RhoGEF kinase isoform 2-An unspecified isoform of DISC1 interacts with HAPIP.-Pubmed

Recent Publications on KALRN:

Pubmed Logo
Kalirin loss results in cortical morphological alterations.
Morphogenesis of pyramidal neuronal dendrites and spines is crucial for...
6th October, 2009
Department of Physiology, Northwestern University Feinberg School of Mol Cell Neurosci. 2009 Sep 30.
DOI Direct Link
Validation study of genetic associations with coronary artery disease on chromosome 3q13-21 and potential effect modification by smoking.
The CATHGEN study reported associations of chromosome 3q13-21 genes...
27th August, 2009
Cardiovascular Department, Intermountain Medical Center, Salt Lake City, Ann Hum Genet. 2009 Nov;73(Pt 6):551-8. Epub 2009 Aug 25.
DOI Direct Link
Kalirin regulates cortical spine morphogenesis and disease-related behavioral phenotypes.
Dendritic spine morphogenesis contributes to brain function, cognition,...
27th August, 2009
Department of Physiology, Northwestern University Feinberg School of Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13058-63. Epub 2009 Jul 22.
DOI Direct Link
Kainic acid-induced F-344 rat model of mesial temporal lobe epilepsy: gene expression and canonical pathways.
Mesial temporal lobe epilepsy (MTLE) is a severe neurological condition of...
25th August, 2009
Department of Pathology, Covance Laboratories Inc., Madison, WI 53704, Toxicol Pathol. 2009;37(6):776-89. Epub 2009 Aug 21.
DOI Direct Link
Pig KALRN, MYH1, MLC2V, SNX13, AK1, and PPIA loci RH mapping and chromosome position refining.
The suppressive subtractive hybridization technique was previously used by...
7th February, 2009
Livestock Genomics, Parco Tecnologico Padano, Lodi, Italy. Genet Mol Res. 2008 Oct 7;7(4):982-5.

View more research publications.

KALRN results (if any) from reagent suppliers

Google CSE Logo
KALRN antibodies: Neuroscience > Neurology process > Neurogenesis ...
KALRN antibodies. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab52012 · KALRN antibody. WB, ELISA ...
http://www.abcam.com/index.html?t=209501&pt=1&c=3379&ei=&mu=...

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Huntington's Disease Antibodies :: Page 1
HAP1 Antibody, 4205, H, M, R, E, WB, IHC, Huntingtin associated protein 1. KALRN Antibody, 46-975, H, M, R, B, Hr, E, (NT) KALRN ...
http://www.prosci-inc.com/shop/catalog1/Huntingtons-Disease-...

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Duo (C-20) Antibody sc-18592
... Protein Accession #, OMIM™ Number. Human, KALRN, 8997, 3q21.1, NM_001024660, NM_003947, NM_007064 · O60229 · 604605. Mouse, Kalrn, 545156, 16 B3, A2CG49 ...
http://www.scbt.com/datasheet-18592-duo-c-20-antibody.html...

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Abcam antibodies and reagents product map
... Hsp27 antibodies (3) · INPPL1 antibodies (2) · KALRN antibodies (1) · KLHL1 antibodies (2) · KLHL1 proteins and peptides (1) · KLHL15 antibodies (1) ...
http://www.abcam.com/index.html?c=2105...

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Duo (C-20) Antibody sc-18592
ヒト, KALRN, 8997, 3q21.1, NM_001024660, NM_003947, NM_007064 · O60229 · 604605. マウス, Kalrn, 545156, 16 B3, A2CG49 ...
http://www.scbt.com/ja/datasheet-18592-duo-c-20-antibody.htm...

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Duo (C-20) Antibody sc-18592
Species, Nome del gene, Codice del gene, Locus cromosoma, Isoform (mRNA) Accession #, codice accesso proteina, Numero d' ordine. Human, KALRN, 8997, 3q21
.1 ...
http://www.scbt.com/it/datasheet-18592-duo-c-20-antibody.htm...

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Duo siRNA (h) sc-41986
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, KALRN, 8997, 3q21.1, NM_001024660, ...
http://www.scbt.com/ko/datasheet-41986-duo-sirna-h.html...

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