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HAP1


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Symbol:HAP1
Name(s):huntingtin-associated protein 1 (neuroan 1)
Type:protein-coding
Organism:Homo sapiens
Synonyms:HAP2, HIP5, HLP, hHLP1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17569884 Observational study of gene-disease association. (HuGE Navigator)
18192679 Observational study of gene-disease association. (HuGE Navigator)
15737634 The combination of siRNA, the SB transposon, and an accurate transgenic mouse model may permit evaluation of this approach in preventing the pathogenesis associated with expression of mutant Htt.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDdynactin 1 isoform 1Huntingtin associated protein 1--Pubmed
BINDhuntingtin-Htt interacts with Hap1.-Pubmed
BINDhuntingtin-Htt interacts with HAP1. This interaction was modeled on a demonstrated interaction between human Htt and Rat HAP1.-Pubmed
HPRDhuntingtinhuntingtin-associated protein 1 isoform 1--Pubmed
HPRDhuntingtinhuntingtin-associated protein 1 isoform 1--Pubmed
BINDhuntingtinhuntingtin-associated protein 1 isoform 2Huntingtin interacts with HAP1.-Pubmed
HPRDNeurogenic differentiation factor 1huntingtin-associated protein 1 isoform 1--Pubmed
HPRDneurogenic differentiation 1Huntingtin associated protein 1--Pubmed
HPRDPericentriolar material 1huntingtin-associated protein 1 isoform 1--Pubmed
HPRDHuman autoantigen pericentriol material 1 mRNA, and translated productsHuntingtin associated protein 1--Pubmed

Recent Publications on HAP1:

Pubmed Logo
Classification of Myoviridae bacteriophages using protein sequence similarity.
BACKGROUND: We advocate unifying classical and genomic classification of...
28th October, 2009
Biosystems Department, Katholieke Universiteit Leuven, Kasteelpark BMC Microbiol. 2009 Oct 26;9:224.
DOI Direct Link
Vitamin D binding protein genotype and osteoporosis.
Osteoporosis is a bone disease leading to an increased fracture risk. It...
21st October, 2009
Department of Internal Medicine, Erasmus Medical Center, Genetic Calcif Tissue Int. 2009 Aug;85(2):85-93. Epub 2009 Jun 2.
DOI Direct Link
A unique mechanism of chaperone action: heme regulation of Hap1 activity involves separate control of repression and activation.
The Hsp90 and Hsp70 molecular chaperones play important roles in the...
15th September, 2009
Department of Molecular and Cell Biology, University of Texas at Dallas, Protein Pept Lett. 2009;16(6):642-9.
Haplotype-tagging single nucleotide polymorphisms in the GSTP1 gene promoter and susceptibility to lung cancer.
BACKGROUND: Glutathione S-transferase (GST) P1 is a major phase II...
21st August, 2009
Laboratory of Human Toxicology and Molecular Epidemiology, Wadsworth Cancer Detect Prev. 2009;32(5-6):403-15. Epub 2009 Mar 17.
DOI Direct Link
Strong Evidence of a Combination Polymorphism of the Tyrosine Kinase 2 Gene and the Signal Transducer and Activator of Transcription 3 Gene as a DNA-Based Biomarker for Susceptibility to Crohn's Disease in the Japanese Population.
OBJECTIVE: An association between susceptibility to inflammatory bowel...
5th August, 2009
Department of Pharmacotherapeutics, Nagasaki University Graduate School of J Clin Immunol. 2009 Aug 4.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Study of Diagnosis and Pathophysiology of Pulmonary Embolism (APE 1 Trial)

Patents:

Patents logo
US Patent No.Title
7098001 Polypeptides having dipeptidyl aminopeptidase activity and nucleic acids encoding same
7241937 Methods and materials for improving plant drought tolerance
7264964 Chimeric histone acetyltransferase polypeptides
7279308 Polynucleotides encoding polypeptides having aminopeptidase activity
7279617 Promoter, promoter control elements, and combinations, and uses thereof

View more patents.

HAP1 results (if any) from reagent suppliers

Google CSE Logo
HAP1 Antibody Huntingtin associated protein 1
HAP1 antibody can be used for detection of HAP1 by Western blot at 0.5 – 1 μg/ml .,
http://www.prosci-inc.com/shop/catalog1/HAP1-Antibody-p-6526...

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HAP1 (R-19) Antibody sc-8770
HAP1 shRNA (h) Lentiviral Particles, sc-94188-V, 200 µl ... HAP1 (R-19): sc-8770 . Western blot analysis of HAP1 expression in rat brain tissue extract. ...
http://www.scbt.com/datasheet-8770-hap1-r-19-antibody.html...

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Huntingtin Associated Protein 1 (HAP1) antibody
This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human HAP1. Other Names
: ...
http://www.abgent.com/products/catalog_no/AP6118a_Huntingtin...

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HAP1 (D-19) Antibody sc-8769
Western blot analysis of HAP1 expression in non-transfected: sc-117752 (A) and mouse HAP1 transfected: sc-125431 (B) 293T whole cell lysates. Download ...
http://www.scbt.com/datasheet-8769-hap1-d-19-antibody.html...

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APE antibody, APE Antibody, Rabbit Polyclonal Antibody
Rabbit polyclonal to APE; 328; APEX1; 107748; P27695; APE; APE1; APEN; APEX; APX ; HAP1; REF-1; REF1;; DNA-(apurinic or apyrimidinic site) lyase, APEX1_HUMAN ...
http://www.genwaybio.com/product_info.php?products_id=196003...

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HAP1 (N-18) Antibody sc-12556
goat polyclonal IgG, 200 µg/ml; epitope mapping near the N-terminus of HAP1 of rat origin; recommended for detection of HAP1A and HAP1B of m, r and h origin
...
http://www.scbt.com/datasheet-12556-hap1-n-18-antibody.html...

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Antibody Products - IgG Polyclonal Antibodies - GenWay
RABBIT ANTI HAP1; Huntingtin-associated protein 1, IgG Polyclonal ... HAP1; HAP2 ; HLP1 - Huntingtin-associated protein 1 isoform 1; N/A, IgG Polyclonal ...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=H...

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