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F2RL3
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 15099288 |
results suggest stimulation of both the PAR1 & PAR4 receptors are necessary for thrombin-induced procoagulant activity, & the P2Y(12) receptor, but not the P2Y(1) receptor, is responsible for potentiation of agonist-induced platelet procoagulant activity |
| 15203717 |
beta- and gamma-thrombin selectively activate PAR-4; physiological roles are demonstrated |
| 11907122 |
When expressed in respiratory epithelial cells and cell lines, protease-activated receptor 4 (PAR4)induces the release of IL-6, IL-8, and PGE2. |
| 16837456 |
Data show that at relatively high concentration of agonist, inhibition of the P2Y12 receptor and of calcium mobilization result in complete inhibition of PAR4-induced aggregation, with no effect on either thrombin or PAR1-mediated platelet aggregation. |
| 12008957 |
The signal from PAR4 stabilizes platelet-platelet aggregate formation in the absence of P2Y12 activation by ADP. |
| 15078882 |
PAR-1 and PAR-4 signal Rap1B activation, the ability of thrombin to activate this GTPase independently of secreted ADP involves costimulation of both receptors as well as binding to GPIb-IX-V. |
| 15045135 |
evidence that only one of the thrombin platelet receptors, PAR1 or PAR4, is sufficient to induce intracellular signaling leading to the cleavage of the beta3 cytoplasmic domain |
| 13678420 |
Protease-activated receptor-4 exodomains utilize dual prolines and an anionic retention motif for thrombin recognition and cleavage. |
| 14973136 |
plasmin induces platelet aggregation primarily through slow cleavage of PAR-4; prolonged incubation with plasmin desensitized platelets to further stimulation by thrombin. |
| 14521606 |
PAR-1 and PAR-4 have roles in activating GPIb translocation into the cytoskeleton in platelets | →View more information from publications. |
F2RL3 results (if any) from reagent suppliers | 
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PAR-4 (M-20) Antibody sc-8462
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, F2rl3, 14065, 8 B3.3, O88634 ...
http://www.scbt.com/datasheet-8462-par-4-m-20-antibody.html...
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PAR-4 siRNA (h) sc-72068
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, F2RL3, 9002, 19p13.11, NM_003950 ...
http://www.scbt.com/datasheet-72068-par-4-sirna-h.html...
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PAR-4 (A-20) Antibody sc-21049
Humain, F2RL3, 9002, 19p13.11, NM_003950 · Q96RI0 · 602779. Souris, F2rl3, 14065 , 8 B3.3, O88634, Non disponible. Produits disponibles ...
http://www.scbt.com/fr/datasheet-21049-par-4-a-20-antibody.h...
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PAR-4 (H-120) Antibody sc-25466
Humano, F2RL3, 9002, 19p13.11, NM_003950 · Q96RI0 · 602779. Ratón, F2rl3, 14065, 8 B3.3, O88634, No Aplicable. Información sobre pedidos ...
http://www.scbt.com/es/datasheet-25466-par-4-h-120-antibody....
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PAR-4 (H-120) Antibody sc-25466
种属, 基因名称, 基因ID, 染色质位置, 亚型（mRNA）即位号码, 蛋白质即位号码, OMIM™ 号码. 人类, F2RL3, 9002, 19p13.11, NM_003950 · Q96RI0 ...
http://www.scbt.com/zh/datasheet-25466-par-4-h-120-antibody....
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