Gene Information from Publications |
| Publication Link |
Summary of findings |
| 14574570 |
expressed in human breast tumors, breast cancer cell lines, and normal breast |
| 12613904 |
Lacritin gene maps near but not within triple A syndome region. Alacrimia in triple a syndrome not due to mutation in lacritin gene. |
| 15952718 |
Lacritin is one of nine tear proteins downregulated in patients suffering from blepharitis, or inflammation of the eyelid often associated with dry eye. |
| 16488965 |
Lacritin is detected by MS in meibomian gland secretions. |
| 16865190 |
Lacritin is detected in human tears by mass spectometry from patients with pterygium. |
| 16982797 |
Heparanase cleavage of SDC1 heparan sulfate chains is required for lacritin binding. This mechanism therefore forms a novel off/on switch for lacritin-dependent mitogenesis. |
| 16982797 |
Lacritin binds a form of SDC1 that lacks or contains short heparan sulfate chains, as revealed by gel filtration of chemically cleaved chains. Also by binding studies with FGF2 purified SDC1 with or without heparitinase digestion. |
| 16982797 |
Lacritin binds human SDC1, but not human SDC2 or SDC4. Lacritin C-5, C-10, N-15, N-24, but not C-25 binds SDC1. C-15 weakly binds. Thus the C-terminal mitogenic and SDC1 binding domains appear to be the same. |
| 16982797 |
Lacritin mitogenesis and COX2 expression is abrogated when SDC1 (but not SDC2) is depleted by siRNA. Similarly siRNA depletion of HPSE1 (but not HPSE2) knocks out lacritin mitogenesis and can be rescued by exogenous HPSE1. |
| 16923831 |
Lacritin calcium signaling is inhibited by pertussis toxin, U73122 and Go 6976. |
→View more information from publications. |
