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CD1B


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Symbol:CD1B
Name(s):CD1b molecule
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD1, CD1A, MGC125990, MGC125991, R1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
11580851 Observational study of gene-disease association. (HuGE Navigator)
11938350 Lipid length controls antigen entry into endosomal and nonendosomal pathways for CD1b presentation.
16874306 The data presented herein explain how the CD1b groove is preserved, and provide a rationale for the in vivo antigen-binding properties of CD1b.
15556687 CD1b expression was detected on monocytes in the majority of sickle cell anemia patients, and was highly expressed in Sbeta thalassemia patients.
14764708 Current crystal structure illustrates for the first time the binding of a natural bacterial lipid antigen to CD1b and shows how its novel structural features fit the CD1b molecule for its role in the immune response to intracellular bacteria.
16794581 Endosomal acidification acts directly, rather than through enzymatic trimming, to insert lipids into CD1b.
14551186 CD1b and CD1c show strong binding of nitrobenzoxadiazole (NBD)-labeled dialkyl-based ligands.
16272286 identified CD1a-, CD1b-, and CD1c-restricted T cells from normal human donors that induce cytolysis and secrete copious IFN-gamma in response to self-CD1 expressed on monocyte-derived dendritic cells
14716313 model proposed in which saposin C exposes lipid antigens from intralysosomal membranes for loading onto CD1b
12049721 Failure of trafficking and antigen presentation by CD1b in AP-3-deficient cells

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDbeta-2-microglobulin precursorCD1B antigen precursor--Pubmed
HPRDbeta-2-microglobulin precursorCD1B antigen precursor--Pubmed

Recent Publications on CD1B:

Pubmed Logo
Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids.
Dendritic cells (DCs) are the key cell type in the regulation of an...
30th October, 2009
Institute of Immunology, Medical University Vienna, Austria; Blood. 2009 Oct 28.
DOI Direct Link
Presentation of lipid antigens by CD1 glycoproteins.
CD1 molecules are a family of non-polymorphic, class I antigen-presenting...
29th October, 2009
Department of Molecular Biology, Skaggs Institute for Chemical Biology, Curr Pharm Des. 2009;15(28):3311-7.
Efficacy of bacille Calmette-Guerin immunotherapy predicted by expression of antigen-presenting molecules and chemokines.
OBJECTIVES: To ascertain the role and prognostic value of...
24th October, 2009
Departamento de Imunologia, Faculdade de Ciencias Medicas de Lisboa, Campo Urology. 2009 Oct;74(4):944-50. Epub 2009 May 9.
DOI Direct Link
The influence of age and Rhodococcus equi infection on CD1 expression by equine antigen presenting cells.
There is a distinct age-associated susceptibility of horses to Rhodococcus...
20th October, 2009
Department of Veterinary Clinical Sciences, Washington State University, Vet Immunol Immunopathol. 2009 Aug 15;130(3-4):197-209. Epub 2009 Feb 14.
DOI Direct Link
CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice.
Group 1 CD1 (CD1a, CD1b, and CD1c)-restricted T cells recognize...
8th October, 2009
Department of Pathology, University of Chicago, Chicago, IL 60637, USA. J Exp Med. 2009 Oct 26;206(11):2497-509. Epub 2009 Oct 5.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6558661 Treatment of inflammatory bowel disease with IFN-.gamma. inhibitors
6936417 Gene expression in bladder tumors
6953568 Targeting of molecules to large vessel endothelium using EPCR
6994848 Lactobacillus paracasei strain GM-080 for treating allergy related diseases
7009862 Semiconductor device

View more patents.

CD1B results (if any) from reagent suppliers

Google CSE Logo
human CD1b antibody, Alexa Fluor® 647 conjugate
eBioscience technical data sheet for product 51-0018 Alexa Fluor® 647 anti-human CD1b eBioSN13 (SN13 K5-1B8) antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_51/51-...

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Anti-CD1b Monoclonal Antibody
Monoclonal Antibody against CD1b for use in Immunofluorescence.
http://www.bioreagents.com/products/productDetails/productDe...

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CD1b antibodies: Immunology > Adaptive Immunity > B Cells > CD | Abcam
CD1b antibodies. ... CD1b antibody [M-T101]. Flow Cyt, IP, IHC-Fr. Mouse monoclonal ... CD1b antibody [MT-101] (FITC). Flow Cyt. Mouse monoclonal ...
http://www.abcam.com/index.html?t=123201&pt=1&c=498&ei=&mu=r...

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CD1 Antibody / CD1 Antibodies
CD1B (3F66) Antibody, sc-70569, mouse IgG1, FL (h), IP, IF, FCM, human ... CD1B/ C (B-B5) Antibody, sc-65296, mouse IgG1, FL (h), FCM, human ...
http://www.scbt.com/table-cd1.html...

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CD1b+c antibodies: Immunology > Immunoglobulins > Receptors | Abcam
CD1b+c antibodies. ... CD1b+c antibody [B-B5] (FITC). Flow Cyt. Images · Specific publication references. Mouse monoclonal. FITC conjugated ...
http://www.abcam.com/index.html?t=127045&pt=1&c=515&ei=&mu=r...

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CD1B (VPM5) Antibody sc-101618
mouse monoclonal IgM, 200µg/ml; raised against afferent lymph denditric cells of sheep origin; recommended for detection of CD1B of sheep, ...
http://www.scbt.com/ko/datasheet-101618-cd1b-vpm5-antibody.h...

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All Non-CD | Abcam
CD1b antibody [MT-101] (FITC). Flow Cyt. Mouse monoclonal. FITC conjugated ... CD1b antibody [WM25]. Flow Cyt, IP, IHC-Fr. Mouse monoclonal ...
http://www.abcam.com/index.html?c=496...

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