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LATS1
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16007220 |
Activation of Omi / HtrA2-mediated cell death is a potential mechanism for the tumor suppressive activity of WARTS. |
| 12372621 |
regulation of function on the mitosis apparatus by Cdc/cyclin B |
| 15688006 |
Mst2, a STE20-family member and purported Hpo ortholog, phosphorylates and activates both Lats1 and Lats2 |
| 12379777 |
molecular alterations found in soft tissue sarcoma |
| 17049657 |
LATS1 and LATS2 mRNA was down-regulated in astrocytoma by hypermethylation of the promoter |
| 15220930 |
LATS1 is a novel cytoskeleton regulator that affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. |
| 15122335 |
WARTS plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G(1) tetraploidy checkpoint |
| 15746036 |
Hypermethylation of the promoter region of LATS1 likely plays an important role in the down-regulation of LATS1 mRNA level in breast cancers, and breast cancers with a decreased expression of LATS1 mRNA level have a biologically aggressive phenotype. |
| 16061636 |
Moderate overexpression of human LATS1 in cells exposed to microtubule poisons facilitated mitotic exit, and this activity required MOB1A. |
| 12624101 |
kpm negatively regulates cell growth by inducing G(2)/M arrest and apoptotic cell death through its kinase activity | →View more information from publications. |
Recent Publications on LATS1: |  |
Mst1 and Mst2 Maintain Hepatocyte Quiescence and Suppress Hepatocellular Carcinoma Development through Inactivation of the Yap1 Oncogene.
Hippo-Lats-Yorkie signaling regulates tissue overgrowth and tumorigenesis... | 3rd November, 2009
| Department of Molecular Biology, Massachusetts General Hospital, Boston,
| Cancer Cell. 2009 Nov 6;16(5):425-38.
DOI Direct Link |
Mst Out and HCC In.
Mst1 and Mst2 are key components of the Hippo tumor suppressor pathway. In... | 3rd November, 2009
| Department of Pharmacology and Moores Cancer Center, University of
| Cancer Cell. 2009 Nov 6;16(5):363-4.
DOI Direct Link |
Comparative expression of zebrafish lats1 and lats2 and their implication in gastrulation movements.
Large tumor suppressor (Lats) is a Ser/Thr kinase, and it presents an... | 21st October, 2009
| Department of Genetics and Center for Developmental Biology, College of
| Dev Dyn. 2009 Nov;238(11):2850-9.
DOI Direct Link |
Transcriptional activation of the Lats1 tumor suppressor gene in tumors of CUX1 transgenic mice.
BACKGROUND: Lats1 (large tumor suppressor 1) codes for a serine/threonine... | 21st October, 2009
| Goodman Cancer Center, McGill University, 1160 Pine Avenue West, Room 410,
| Mol Cancer. 2009 Aug 5;8:60.
DOI Direct Link |
Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray.
Human LATS1 and LATS2) (LATS1/2) are tumor suppressors that have been... | 6th October, 2009
| Department of Pathology and Molecular Medicine, Queen's University,
| Gene. 2010 Jan 1;449(1-2):22-29. Epub 2009 Sep 30.
DOI Direct Link |
→View more research publications. |
LATS1 results (if any) from reagent suppliers | 
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