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AIFM1


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Symbol:AIFM1
Name(s):apoptosis-inducing factor, mitochondrion-associated, 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:AIF, MGC111425, PDCD8
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18056262 Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis
17471535 PKB/Akt inhibits ceramide-induced apoptosis in neuroblastoma cells by blocking AIF translocation.
17492772 Data suggest that erythroblast chromatin degradation may involve caspase activated DNase and apoptosis inducing factor, enzymes distinct from those active in apoptotic cells.
17709377 TULA enhances the apoptotic effect of AIF by facilitating the interactions of AIF with its apoptotic co-factors
17347867 study of cellular localization of the endonuclease G, AIF & AMID during apoptosis using bioinformatics and image analysis
17560018 AIF is associated with cisplatin induced apoptosis in prostate cancer
17603079 Inhibitor of apoptosis proteins, nuclear factor-kappa, Smac/DIABLO and apoptosis inducing factor were increased in colon cancer cells.
17352692 Down-regulation of hSUV3 results in cell cycle perturbations and in apoptosis, which is both AIF- and caspase-dependent, and proceeds with the induction of p53.
17107772 Hypochlorous acid induced Bax-dependent mitochondrial permeability which led to cell death without caspase activity by processes involving AIF/EndoG-dependent pathways.
12629154 Possible contribution of apoptosis-inducing factor and reactive oxygen species to UVB-induced caspase-independent cell death in the T cell

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDheat shock 70kDa protein 1Aprogrammed cell death 8 isoform 1--Pubmed
HPRDheat shock 70kDa protein 1Aprogrammed cell death 8 isoform 1--Pubmed
HPRDMAP/ERK kinase kinase 3programmed cell death 8 isoform 1--Pubmed
HPRDnuclear factor of kappa light polypeptide gene enhancer in B-cells 2programmed cell death 8 isoform 1--Pubmed
HPRDv-rel reticuloendotheliosis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B-cells 3, p65programmed cell death 8 isoform 1--Pubmed
HPRDtumor necrosis factor receptor 2 precursorprogrammed cell death 8 isoform 1--Pubmed
HPRDTNFRSF1A-associated via death domainprogrammed cell death 8 isoform 1--Pubmed
HPRDTNFRSF1A-associated via death domainprogrammed cell death 8 isoform 1--Pubmed
HPRDprogrammed cell death 8 isoform 1receptor-interacting serine-threonine kinase 3--Pubmed

Recent Publications on AIFM1:

Pubmed Logo
Capsaicin-induced apoptosis is regulated by endoplasmic reticulum stress- and calpain-mediated mitochondrial cell death pathways.
Capsaicin, a pungent compound found in hot chili peppers, induces...
14th October, 2009
Department of Pathology, College of Medicine, Chosun University, Dong-Gu, Toxicology. 2009 Oct 29;264(3):205-14. Epub 2009 Aug 20.
DOI Direct Link
Enhanced dopaminergic differentiation of human neural stem cells by synergistic effect of Bcl-xL and reduced oxygen tension.
Neural stem cells constitute a promising source of cells for...
30th September, 2009
Department of Anatomy and Neurobiology, Institute of Medical Biology, J Neurochem. 2009 Sep;110(6):1908-20. Epub 2009 Jul 17.
DOI Direct Link
Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms.
Helenalin is a naturally occuring sesquiterpene lactone extracted from...
19th September, 2009
Department of Transplantation Immunology, Institute of Immunology, Mol Immunol. 2009 Sep;46(15):2892-901. Epub 2009 Aug 5.
DOI Direct Link
Left ventricular global transcriptional profiling in human end-stage dilated cardiomyopathy.
We employed ABI high-density oligonucleotide microarrays containing 31,700...
2nd September, 2009
Department of Biostatistics, Epidemiology and Scientific Computing, King Genomics. 2009 Jul;94(1):20-31. Epub 2009 Mar 28.
DOI Direct Link
Postnatal Age Influences Hypoglycemia-induced Poly(ADP-ribose) Polymerase-1 Activation in the Brain Regions of Rats.
Poly(ADP-ribose) polymerase-1 (PARP-1) overactivation plays a significant...
19th August, 2009
Department of Pediatrics [R.R., D.S., K.E.] and Center for Neurobehavioral Pediatr Res. 2009 Aug 14.
DOI Direct Link

View more research publications.

AIFM1 results (if any) from reagent suppliers

Google CSE Logo
AIFM1 Antibody Apoptosis-inducing Factor
AIFM1 Antibody 49-571, ... Immunogen. AIFM1 antibody was raised against amino acids 517-531 of AIFM1. Application. AIFM1 antibody can be used for detection
...
http://www.prosci-inc.com/shop/catalog1/AIFM1-Antibody-p-333...

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Aifm1 antibody, AIF Antibody, Rabbit Polyclonal Antibody
Buy quality rabbit Aifm1 antibody (interacts with target species: human reacts with: rat. mouse nb), anti-Aifm1, AIF antibody, rabbit polyclonal antibody, ...
http://www.genwaybio.com/product_info.php?products_id=76434...

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AIFM1 Antibody Apoptosis-inducing Factor
AIFM1 Antibody 49-526, ... Immunogen. AIFM1 antibody was raised against amino acids 593 to 606 of AIFM1. Application. AIFM1 antibody can be used for ...
http://www.prosci-inc.com/shop/catalog1/AIFM1-Antibody-p-333...

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Antibodies to Mitochondrial Proteins
mouse ... Aifm1(26926) human ... AIFM1(9131), human, mouse, ARR, WB, pricing. C5723, Anti-Cytochrome c antibody produced in sheep, whole antiserum ...
https://www.sigmaaldrich.com/etc/controller/controller-page....

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Apoptosis Antibodies :: Page 1
AIF Antibody, 2301, H, M, R, E, WB, ICC, (CT) Apoptosis Inducing Factor. AIFM1 Antibody, 49-526, H, WB, IHC, Apoptosis-inducing Factor ...
http://www.prosci-inc.com/shop/catalog1/Apoptosis-Antibodies...

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AIF (E-1) Antibody sc-13116
Human, AIFM1, 9131, Xq25, NM_004208, NM_145812, NM_145813 · O95831 · 300169. Mouse, Aifm1, 26926, X A4, Q9Z0X1, N/A. Ordering Information ...
http://www.scbt.com/datasheet-13116-aif-e-1-antibody.html...

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Antibodies to Mitochondrial Proteins
A7549, Anti-Apoptosis-Inducing Factor antibody produced in rabbit, (polyclonal), IgG fraction of antiserum, mouse ... Aifm1(26926) human ... AIFM1(9131) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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