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ARHGEF1
| Symbol: | ARHGEF1 | | Name(s): | Rho guanine nucleotide exchange factor (GEF) 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | GEF1, LBCL2, LSC, P115-RHOGEF, SUB1.5 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17493936 |
analysis of a novel cross-talk exerted from the LPA/Galpha(13)/p115RhoGEF/RhoA pathway to the beta(2)-adrenergic receptor/Galpha(s)/adenylyl cyclase pathway |
| 12748184 |
CD44 interaction with p115RhoGEF and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3-kinase membrane localization, AKT signaling, and cytokine (M-CSF) production during HA-mediated breast cancer progression |
| 12372594 |
coexpression of a dominant negative PDZ-RhoGEF abrogated the ability of plexin-B1 to cause stress fiber formation |
| 12525488 |
rgRGS domain may serve a structural or allosteric role in the regulation of the nucleotide exchange activity of p115RhoGEF on Rho by Galpha(13) |
| 15735747 |
Several features of a typical alpha/RGS interaction are preserved in the alpha(13)/p115RhoGEF interaction. |
| 12754211 |
data demonstrate a pathway of Rho activation involving protein kinase c alpha-dependent phosphorylation of p115Rho guanine exchange factor |
| 15143072 |
Data show that different rho guanine nucleotide exchange factors (rhoGEFs; p115rhoGEF, LARG and PDZrhoGEF) mediate downstream rho signaling by the thrombin and lysophosphatidic acid receptors. |
Recent Publications on ARHGEF1: |  |
Identification of potential therapeutic targets in hypertension-associated bladder dysfunction.
OBJECTIVE To investigate differential gene expression profiles in the... | 20th August, 2009
| Department of Urology, Graduate School of Medical Sciences, Kumamoto
| BJU Int. 2009 Aug 18.
DOI Direct Link |
Lsc activity is controlled by oligomerization and regulates integrin adhesion.
Lsc is a hematopoietic-restricted protein that functions as an effector of... | 25th April, 2008
| Integrated Department of Immunology, University of Colorado Health
| Mol Immunol. 2008 Apr;45(7):1825-36. Epub 2007 Dec 21.
DOI Direct Link |
Expression of RHOGTPase regulators in human myometrium.
BACKGROUND: RHOGTPases play a significant role in modulating myometrial... | 26th March, 2008
| National Centre for Biomedical and Engineering Science, Orbsen Building,
| Reprod Biol Endocrinol. 2008 Jan 11;6:1.
DOI Direct Link |
Gene expression signature in peripheral blood cells from medical students exposed to chronic psychological stress.
To assess response to chronic psychological stress, gene expression... | 1st March, 2008
| Department of Stress Science, Institute of Health Biosciences, University
| Biol Psychol. 2007 Oct;76(3):147-55. Epub 2007 Jul 31.
DOI Direct Link |
Arhgef1 is required by T cells for the development of airway hyperreactivity and inflammation.
RATIONALE: Arhgef1 is an intracellular protein, expressed by hematopoietic... | 6th December, 2007
| Integrated Department of Immunology, University of Colorado at Denver and
| Am J Respir Crit Care Med. 2007 Jul 1;176(1):10-9. Epub 2007 Apr 26.
DOI Direct Link |
→View more research publications. |
ARHGEF1 results (if any) from reagent suppliers | 
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RhoGEF p115/Lsc (H-165) Antibody sc-20804
... Protein Accession #, OMIM™ Number. Human, ARHGEF1, 9138, 19q13.2, NM_004706, NM_198977, NM_199002 · Q92888 · 601855. Mouse, Arhgef1, 16801, 7 A3, Q61210 ...
http://www.scbt.com/datasheet-20804-rhogef-p115-lsc-h-165-an...
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Abgent - Cell and Function Antibodies
AT1184aNEW, ARHGEF1 monoclonal antibody (M02), ELISA,S-ELISA,WB-Re, H. AT1185a NEW, ARHGEF1 monoclonal antibody (M03), ELISA,IF,S-ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function...
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Lsc (M-19) Antibody sc-8491
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Arhgef1, 16801, 7 A3, Q61210 ...
http://www.scbt.com/datasheet-8491-lsc-m-19-antibody.html...
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p115 RhoGEF (D25D2) XP™ Rabbit mAb
(2). p115 RhoGEF/ArhGEF1 and its family members PDZ-. RhoGEF (PRG), and LARG are stimulated by heteromeric. G proteins and thus couple signaling from GPCRs ...
http://www.cellsignal.com/pdf/3669.pdf...
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Abcam antibodies and reagents product map
... ARHGAP9 antibodies (1) · ARHGDIG antibodies (1) · ARHGEF1 antibodies (2) · ARHGEF10 antibodies (1) · ARHGEF11 antibodies (1) · ARHGEF14 antibodies (1) ...
http://www.abcam.com/index.html?cl=2105&pageconfig=productma...
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