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EBAG9


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Symbol:EBAG9
Name(s):estrogen receptor binding site associated, antigen, 9
Type:protein-coding
Organism:Homo sapiens
Synonyms:EB9, PDAF, RCAS1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17604121 possible role of the RCAS1 protein in the development of pre-eclampsia through an immunological pathway.
17466050 High-level expression of RCAS1 is involved in the malignant transformation of endometrium, and RCAS1 coexpression with ER-alpha may be associated with development and metastasis of endometrial carcinoma
17717421 the drop of the RCAS1 level, which could be a result of an insufficiency of the compensatory immune response mechanisms in tubal mucosa (although these mechanisms are simultaneously preserved in endometrium), leads to tubal perforation.
17825484 Results show that the suppression of RCAS1 expression effectively recover T cell proliferation, reduce apoptosis and partially reverse the T cell function of IFN-gamma secretion.
17981616 RCAS1 is a bioactive marker that induces connective tissue remodeling and lymphocyte apoptosis [review]
17849467 RCAS1 may be a pivotal regulator of tumor growth through angiogenesis.
17845206 The limited immune cells infiltration in decidua during severe pre-eclampsia is associated with increase in RCAS1 decidual level.
15904507 the estrogen-inducible EBAG9 gene-product and the 22-1-1 defined antigen are structurally and functionally separate antigens
14981953 The mean survival of patients who had primary hepatocellular carcinoma with high RCAS1 protein expression was significantly longer than that of patients with low expression.
16211275 expression of RCAS1 is correlated with recurrence not only in carcinomas, but also in mesenchymal tumors

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
BINDconserved helix-loop-helix ubiquitous kinaseHomo sapiens chromosome 8, reference assembly.IKK-alpha interacts with EBAG9 promoter.-Pubmed
BINDestrogen receptor 1Homo sapiens chromosome 8, reference assembly.ER-alpha interacts with EBAG9 promoter.-Pubmed
BINDDNA directed RNA polymerase II polypeptide AHomo sapiens chromosome 8, reference assembly.Pol II interacts with EBAG9 promoter.-Pubmed
BIND-Homo sapiens chromosome 8, reference assembly.AIB1 interacts with EBAG9 promoter.-Pubmed
BINDestrogen receptor binding site associated antigen 9SNAP-associated proteinEBAG9 interacts with Snapin.-Pubmed

Recent Publications on EBAG9:

Pubmed Logo
Diagnostic and prognostic utility of serum receptor-binding cancer antigen expressed on SiSo cells (RCAS1) levels in colon cancer patients.
Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) is a human...
9th October, 2009
Department of Forensic Medicine and Toxicology, Medical School, University Int J Biol Markers. 2009 Apr-Jun;24(2):70-6.
The level of RCAS1 expression is inversely correlated with the number of vimentin-positive stromal cells in epithelial ovarian cancer.
Expression of RCAS1 is significantly associated with clinical prognosis in...
2nd September, 2009
Department of Obstetrics and Gynecology, Graduate School of Medical Int J Gynecol Cancer. 2009 Jul;19(5):838-43.
DOI Direct Link
Alterations in RCAS1 serum concentration levels during menstrual cycle in patients with uterine leiomyoma and lack of analogical changes in adenomyosis.
INTRODUCTION: The selective suppression phenomenon of the cytotoxic immune...
1st September, 2009
Department of Gynecology, Obstetrics and Oncology, The Jagiellonian Gynecol Obstet Invest. 2009;67(3):195-201. Epub 2008 Dec 20.
DOI Direct Link
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells.
CTLs eliminate virus-infected and tumorigenic cells through exocytosis of...
28th August, 2009
Max-Delbruck-Center for Molecular Medicine, Berlin, Germany. J Clin Invest. 2009 Aug;119(8):2184-203. doi: 10.1172/JCI37760. Epub 2009
DOI Direct Link
EBAG9 tempers lymphocyte killing activity.
The cytotoxic activity of lymphocytes is crucial for immune surveillance...
28th August, 2009
INSERM U768, Paris, France. J Clin Invest. 2009 Aug;119(8):2136-40. doi: 10.1172/JCI40270. Epub 2009
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7595159 Prediction of Parkinson's disease using gene expression levels of peripheral blood samples
7547687 Therapeutic treatment methods
7482334 Therapeutic treatment methods

EBAG9 results (if any) from reagent suppliers

Google CSE Logo
EBAG9 antibodies: Cancer > Tumor immunology > Tumor-associated ...
EBAG9 antibodies. ... EBAG9 antibody [ZR001] - Carboxyterminal end. IHC-P, WB, ELISA. Images. Mouse monoclonal. Reacts with: Hu. Predicted: Ms, Rat ...
http://www.abcam.com/index.html?t=209625&pt=1&c=4315&ei=&mu=...

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Abgent - Cancer Antibodies - Cancer
AT1838aNEW, E2F6 monoclonal antibody (M02), ELISA,IF,S-ELISA,WB-Ce,WB-Re, H. AT1842aNEW, EBAG9 monoclonal antibody (M04), ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/cell_function/cancer...

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EBAG9 proteins and peptides: Cancer > Tumor biomarkers > Tumor ...
EBAG9 proteins and peptides. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab79243 · EBAG9 protein (His tag). SDS-PAGE ...
http://www.abcam.com/index.html?t=209625&pt=2&c=4377&ei=&mu=...

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Abgent - Transcription and Regulation Antibodies ...
AT1839aNEW, E2F8 monoclonal antibody (M01), ELISA,S-ELISA,WB-Re, H. AT1842aNEW, EBAG9 monoclonal antibody (M04), ELISA,WB-Ce,WB-Re, H ...
http://www.abgent.com/products/category/nuclear_signaling/tr...

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Lck antibody (ab3885) | Abcam
The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells. J Clin Invest 119:2184-203 (2009). ...
http://www.abcam.com/Lck-antibody-ab3885.html...

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RCAS1 (N-18) Antibody sc-23394
EBAG9 inducing hyporesponsiveness of T cells promotes tumor growth and metastasis in 4T1 murine mammary carcinoma. Cancer Sci. 100: 961-969. ...
http://www.scbt.com/ja/datasheet-23394-rcas1-n-18-antibody.h...

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SNAPAP protein, SNARE-associated protein Snapin recombinant protein
EBAG9 adds a new layer of control on large dense-core vesicle exocytosis via interaction with Snapin [2] Buxton,P., Zhang,X.M., Walsh,B., Sriratana,A., ...
http://www.genwaybio.com/product_info.php?products_id=5207...

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