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EDG4


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Symbol:EDG4
Name(s):endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
Type:protein-coding
Organism:Homo sapiens
Synonyms:EDG-4, LPA2, LPAR2
Links: Pubmed, Entrez Gene, GeneCards, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17965021 lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival
16904289 These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA.
15755723 formation of the LPA receptor/PDZ domain-containing RhoGEF complex plays a pivotal role in LPA-induced RhoA activation
15728708 LPA2 is the major LPA receptor in colon cancer cells and cellular signals by LPA2 are largely mediated through its ability to interact with NHERF2.
15535846 Upregulation of LPA2 may play a role in carcinogenesis, particularly in postmenopausal breast cancer.
12123830 demonstrate that two biological fluids, blood plasma and seminal plasma, differentially activate LPA receptors
12759391 LPA may directly increase the level of cyclin D1 in ovarian cancer cells, increasing their proliferation.
12668280 results suggested that LPA(2) and LPA(3) may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis
17496233 EDG4 and EDG2 cooperate to promote LPA-stimulated chemotaxis in breast tumor cell lines.

Recent Publications on EDG4:

Pubmed Logo
[Expression and significance of Edg4 and Edg7 in the placentas of patients with hypertensive disorder complicating pregnancy]
OBJECTIVE: To study Edg4 and Edg7 expression in placenta of women with...
11th October, 2008
Department of Gynecology and Obstetrics, the First Affiliated Hospital of Zhonghua Fu Chan Ke Za Zhi. 2007 Jun;42(6):386-9.
Analysis of Lysophosphatidic Acid Receptor and Lysophosphatidic Acid-Induced Endometrial PTGS2 Expression in The Porcine Uterus.
Lysophosphatidic acid (LPA), a simple phospholipid-derived mediator with...
16th August, 2008
Department of Biological Resources and Technology, Yonsei University, Endocrinology. 2008 Aug 14.
DOI Direct Link
Full-length coding sequences, polymorphism and chromosomal localizations of the porcine EDG4 and EDG7 genes.
EDG4 and EDG7 are identified as cellular receptors for lysophosphatidic...
2nd April, 2008
Department of Veterinary Internal Medicine, College of Veterinary Mol Biol Rep. 2008 Apr 1.
DOI Direct Link
Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents.
The LPA(2) protein is overexpressed in many tumor cells. We report the...
25th March, 2008
Chemistry Research & Discovery, Amgen Inc., 1120 Veterans Boulevard, South Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41. Epub 2008 Jan 4.
DOI Direct Link
[Vector construction and silencing effect of Edg4 gene targeted small interfering RNA in ovarian cancer cell line]
OBJECTIVE: To construct the recombinant eukaryotic expression vector...
1st March, 2008
Department of Obstetrics and Gynecology, the First Affiliated Hospital of Zhonghua Fu Chan Ke Za Zhi. 2007 Nov;42(11):765-9.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7417065 Immunosuppressant compounds and compositions
7026121 Methods and compositions for diagnosing and monitoring transplant rejection
7014838 Use of biomolecular targets in the treatment and visualization of brain tumors
6905827 Methods and compositions for diagnosing or monitoring auto immune and chronic inflammatory diseases
6812335 Human polypeptide receptors for lysophospholipids and sphingolipids and nucleic acids encoding the same

View more patents.

EDG4 results (if any) from reagent suppliers

Google CSE Logo
EDG4 antibody (ab13349) datasheet | Abcam
Rabbit polyclonal to EDG4. EDG4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. There are eight known members of
the ...
http://www.abcam.com/index.html?datasheet=13349...

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EDG4 Antibody (N-term)
AP6140a) is used in Western blot to detect EDG4 in HL60 lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, ...
http://www.abgent.com/catalog_no/AP6140a...

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EDG4 antibody - Aminoterminal end (ab38322) datasheet | Abcam
Rabbit polyclonal to EDG4 - Aminoterminal end. EDG4 belongs to a family of G- protein coupled receptors whose ligands are lysophospholipids.
http://www.abcam.com/index.html?datasheet=38322...

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EDG4 Antibody (N-term)
Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein
kinases ...
http://www.abgent.com/products/catalog_no/AP6140a/background...

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EDG4 endothelial differentiation, lysophosphatidic acid G-protein ...
G protein-coupled receptor; LPA receptor EDG4; lysophosphatidic acid receptor EDG4. Accession No.(s). AF011466; AF197929; AF233092; AK123043; AY322548; ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

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Orbigen Inc. - Orbigen Inc.
The integral membrane protein endothelial differentiation sphingolipid G-protein -coupled receptor 4 (EDG4) is a lysophosphatidic acid (LPA) receptor from a ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

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Edg4 endothelial differentiation, lysophosphatidic acid G-protein ...
Official Symbol. Edg4. Species. Mus musculus. Entrez Gene ID. 53978. Alternate Symbol. Edg4; EDG4; IPA2; LPA2. Refseq ID(s). NM_020028. Accession No.(s) ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...

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Exalpha Biologicals, Inc.
X1570P, Lysophosphatidic Acid 2 (LPA2) Receptor (EDG4) CT, Polyclonal Antibody ... X1573B, Lysophosphatidic Acid Receptor 2 (EDG4) CT, Blocking Peptide ...
http://exalpha.com/Searchresults1.php?menuvalue=Category&Sea...

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View Cart
EDG4 Antibody (N-term), AP6140a, 0.1mg, $235.00, $235.00. Shipping, flat fee, $35.00. Tax will be added to the Total after the order is processed. ...
https://www.abgent.com/store/add_to_cart/AP6140a...

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Validation & Assay Performance Summary
contain the human Endothelial Differentiation Gene 4 (EDG4) (EDG4) linked to a TEV ... addition, Tangoâ„¢ EDG4-bla U2OS cells have been tested for assay ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf/GP...

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