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EDG4
| Symbol: | EDG4 | | Name(s): | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | EDG-4, LPA2, LPAR2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17965021 |
lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival |
| 16904289 |
These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA. |
| 15755723 |
formation of the LPA receptor/PDZ domain-containing RhoGEF complex plays a pivotal role in LPA-induced RhoA activation |
| 15728708 |
LPA2 is the major LPA receptor in colon cancer cells and cellular signals by LPA2 are largely mediated through its ability to interact with NHERF2. |
| 15535846 |
Upregulation of LPA2 may play a role in carcinogenesis, particularly in postmenopausal breast cancer. |
| 12123830 |
demonstrate that two biological fluids, blood plasma and seminal plasma, differentially activate LPA receptors |
| 12759391 |
LPA may directly increase the level of cyclin D1 in ovarian cancer cells, increasing their proliferation. |
| 12668280 |
results suggested that LPA(2) and LPA(3) may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis |
| 17496233 |
EDG4 and EDG2 cooperate to promote LPA-stimulated chemotaxis in breast tumor cell lines. |
Recent Publications on EDG4: |  |
[Expression and significance of Edg4 and Edg7 in the placentas of patients with hypertensive disorder complicating pregnancy]
OBJECTIVE: To study Edg4 and Edg7 expression in placenta of women with... | 11th October, 2008
| Department of Gynecology and Obstetrics, the First Affiliated Hospital of
| Zhonghua Fu Chan Ke Za Zhi. 2007 Jun;42(6):386-9.
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Analysis of Lysophosphatidic Acid Receptor and Lysophosphatidic Acid-Induced Endometrial PTGS2 Expression in The Porcine Uterus.
Lysophosphatidic acid (LPA), a simple phospholipid-derived mediator with... | 16th August, 2008
| Department of Biological Resources and Technology, Yonsei University,
| Endocrinology. 2008 Aug 14.
DOI Direct Link |
Full-length coding sequences, polymorphism and chromosomal localizations of the porcine EDG4 and EDG7 genes.
EDG4 and EDG7 are identified as cellular receptors for lysophosphatidic... | 2nd April, 2008
| Department of Veterinary Internal Medicine, College of Veterinary
| Mol Biol Rep. 2008 Apr 1.
DOI Direct Link |
Discovery of potent LPA2 (EDG4) antagonists as potential anticancer agents.
The LPA(2) protein is overexpressed in many tumor cells. We report the... | 25th March, 2008
| Chemistry Research & Discovery, Amgen Inc., 1120 Veterans Boulevard, South
| Bioorg Med Chem Lett. 2008 Feb 1;18(3):1037-41. Epub 2008 Jan 4.
DOI Direct Link |
[Vector construction and silencing effect of Edg4 gene targeted small interfering RNA in ovarian cancer cell line]
OBJECTIVE: To construct the recombinant eukaryotic expression vector... | 1st March, 2008
| Department of Obstetrics and Gynecology, the First Affiliated Hospital of
| Zhonghua Fu Chan Ke Za Zhi. 2007 Nov;42(11):765-9.
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→View more research publications. |
EDG4 results (if any) from reagent suppliers | 
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EDG4 antibody (ab13349) datasheet | Abcam
Rabbit polyclonal to EDG4. EDG4 belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. There are eight known members of
the ...
http://www.abcam.com/index.html?datasheet=13349...
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EDG4 Antibody (N-term)
AP6140a) is used in Western blot to detect EDG4 in HL60 lysate. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, ...
http://www.abgent.com/catalog_no/AP6140a...
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EDG4 antibody - Aminoterminal end (ab38322) datasheet | Abcam
Rabbit polyclonal to EDG4 - Aminoterminal end. EDG4 belongs to a family of G- protein coupled receptors whose ligands are lysophospholipids.
http://www.abcam.com/index.html?datasheet=38322...
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EDG4 Antibody (N-term)
Abgent develops powerful tools to profile posttranslational modifications related to cellular function and disease. Abgent antibodies target protein
kinases ...
http://www.abgent.com/products/catalog_no/AP6140a/background...
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EDG4 endothelial differentiation, lysophosphatidic acid G-protein ...
G protein-coupled receptor; LPA receptor EDG4; lysophosphatidic acid receptor EDG4. Accession No.(s). AF011466; AF197929; AF233092; AK123043; AY322548; ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...
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Orbigen Inc. - Orbigen Inc.
The integral membrane protein endothelial differentiation sphingolipid G-protein -coupled receptor 4 (EDG4) is a lysophosphatidic acid (LPA) receptor from a ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...
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Edg4 endothelial differentiation, lysophosphatidic acid G-protein ...
Official Symbol. Edg4. Species. Mus musculus. Entrez Gene ID. 53978. Alternate Symbol. Edg4; EDG4; IPA2; LPA2. Refseq ID(s). NM_020028. Accession No.(s) ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...
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Exalpha Biologicals, Inc.
X1570P, Lysophosphatidic Acid 2 (LPA2) Receptor (EDG4) CT, Polyclonal Antibody ... X1573B, Lysophosphatidic Acid Receptor 2 (EDG4) CT, Blocking Peptide ...
http://exalpha.com/Searchresults1.php?menuvalue=Category&Sea...
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View Cart
EDG4 Antibody (N-term), AP6140a, 0.1mg, $235.00, $235.00. Shipping, flat fee, $35.00. Tax will be added to the Total after the order is processed. ...
https://www.abgent.com/store/add_to_cart/AP6140a...
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Validation & Assay Performance Summary
contain the human Endothelial Differentiation Gene 4 (EDG4) (EDG4) linked to a TEV ... addition, Tango™ EDG4-bla U2OS cells have been tested for assay ...
http://www.invitrogen.com/etc/medialib/en/filelibrary/pdf/GP...
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