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EDG4
| Symbol: | EDG4 | | Name(s): | endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | EDG-4, LPA2, LPAR2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 17965021 |
lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival |
| 16904289 |
These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA. |
| 15755723 |
formation of the LPA receptor/PDZ domain-containing RhoGEF complex plays a pivotal role in LPA-induced RhoA activation |
| 15728708 |
LPA2 is the major LPA receptor in colon cancer cells and cellular signals by LPA2 are largely mediated through its ability to interact with NHERF2. |
| 15535846 |
Upregulation of LPA2 may play a role in carcinogenesis, particularly in postmenopausal breast cancer. |
| 12123830 |
demonstrate that two biological fluids, blood plasma and seminal plasma, differentially activate LPA receptors |
| 12759391 |
LPA may directly increase the level of cyclin D1 in ovarian cancer cells, increasing their proliferation. |
| 12668280 |
results suggested that LPA(2) and LPA(3) may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis |
| 17496233 |
EDG4 and EDG2 cooperate to promote LPA-stimulated chemotaxis in breast tumor cell lines. |
Recent Publications on EDG4: |  |
Non-Edg family lysophosphatidic acid (LPA) receptors.
Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a... | 16th June, 2009
| Department of Biochemistry and Molecular Biology, Faculty of Medicine, The
| Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):57-65. Epub 2009 Jun
DOI Direct Link |
Full-length coding sequences, polymorphism and chromosomal localizations of the porcine EDG4 and EDG7 genes.
EDG4 and EDG7 are identified as cellular receptors for lysophosphatidic... | 2nd June, 2009
| Department of Veterinary Internal Medicine, College of Veterinary
| Mol Biol Rep. 2009 Apr;36(4):751-6. Epub 2008 Apr 1.
DOI Direct Link |
Analysis of lysophosphatidic acid (LPA) receptor and LPA-induced endometrial prostaglandin-endoperoxide synthase 2 expression in the porcine uterus.
Lysophosphatidic acid (LPA), a simple phospholipid-derived mediator with... | 1st April, 2009
| Department of Biological Resources and Technology, Yonsei University,
| Endocrinology. 2008 Dec;149(12):6166-75. Epub 2008 Aug 14.
DOI Direct Link |
[Vector construction and silencing effect of Edg4 gene targeted small interfering RNA in ovarian cancer cell line]
OBJECTIVE: To construct the recombinant eukaryotic expression vector... | 27th January, 2009
| Department of Obstetrics and Gynecology, the First Affiliated Hospital of
| Zhonghua Fu Chan Ke Za Zhi. 2007 Nov;42(11):765-9.
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[Expression and significance of Edg4 and Edg7 in the placentas of patients with hypertensive disorder complicating pregnancy]
OBJECTIVE: To study Edg4 and Edg7 expression in placenta of women with... | 11th October, 2008
| Department of Gynecology and Obstetrics, the First Affiliated Hospital of
| Zhonghua Fu Chan Ke Za Zhi. 2007 Jun;42(6):386-9.
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→View more research publications. |
EDG4 results (if any) from reagent suppliers | 
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EDG-4 (H-55) Antibody sc-25490
EDG-4 shRNA (h) Lentiviral Particles, sc-39926-V, 200 µl ... EDG-4 (H-55): sc- 25490. Western blot analysis of EDG-4 expression in BT-20 (A), MDA-MB-231 (B),
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http://www.scbt.com/datasheet-25490-edg-4-h-55-antibody.html...
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EDG4 antibodies: Signal Transduction > Signaling Pathway > G ...
EDG4 antibodies. ... EDG4 antibody. IHC-P, ICC. Rabbit polyclonal ... EDG4 antibody - Aminoterminal end. IHC-P, WB, ELISA. Images. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=76618&pt=1&c=2191&ei=&mu=r...
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EDG-4 (C-16) Antibody sc-16082
EDG-4 shRNA (h) Lentiviral Particles, sc-39926-V, 200 µl ... See how others have used EDG-4 (C-16): sc-16082 antibody and or EDG-4 (C-16) antibody ...
http://www.scbt.com/datasheet-16082-edg-4-c-16-antibody.html...
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Orbigen Inc. - Orbigen Inc.
The integral membrane protein endothelial differentiation sphingolipid G-protein -coupled receptor 4 (EDG4) is a lysophosphatidic acid (LPA) receptor from a ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...
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EDG-4 Antibody / EDG-4 Antibodies
EDG-4 Antibody / EDG-4 Antibodies. ... EDG-4 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-edg-4.html...
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Monoclonal Anti-LPA2, N-Terminal antibody produced in mouse (E3141 ...
(EDG-4), N-Terminal protein from human tissue by immunoblotting (45 kDa). The antibody does not ... LPA2, also known as EDG-4, belongs to a family of ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...
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EDG4 (LPA2) Functional Receptor Membrane Preparation
27 Jan 2003 ... EDG-4 belongs to a family of G-protein coupled receptors whose ... G-protein coupled EDG4 receptors. NOTE: The protocol below has been ...
http://www.exalpha.com/pdfs/X1546MP.pdf...
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