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EDG4


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Symbol:EDG4
Name(s):endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 4
Type:protein-coding
Organism:Homo sapiens
Synonyms:EDG-4, LPA2, LPAR2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17965021 lysophosphatidic acid 2 receptor mediates down-regulation of Siva-1 to promote cell survival
16904289 These results demonstrate that MAGI-3 interacts directly with LPA(2) and regulates the ability of LPA(2) to activate Erk and RhoA.
15755723 formation of the LPA receptor/PDZ domain-containing RhoGEF complex plays a pivotal role in LPA-induced RhoA activation
15728708 LPA2 is the major LPA receptor in colon cancer cells and cellular signals by LPA2 are largely mediated through its ability to interact with NHERF2.
15535846 Upregulation of LPA2 may play a role in carcinogenesis, particularly in postmenopausal breast cancer.
12123830 demonstrate that two biological fluids, blood plasma and seminal plasma, differentially activate LPA receptors
12759391 LPA may directly increase the level of cyclin D1 in ovarian cancer cells, increasing their proliferation.
12668280 results suggested that LPA(2) and LPA(3) may be involved in VEGF expression mediated by LPA signals in human ovarian oncogenesis
17496233 EDG4 and EDG2 cooperate to promote LPA-stimulated chemotaxis in breast tumor cell lines.

Recent Publications on EDG4:

Pubmed Logo
Non-Edg family lysophosphatidic acid (LPA) receptors.
Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a...
16th June, 2009
Department of Biochemistry and Molecular Biology, Faculty of Medicine, The Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):57-65. Epub 2009 Jun
DOI Direct Link
Full-length coding sequences, polymorphism and chromosomal localizations of the porcine EDG4 and EDG7 genes.
EDG4 and EDG7 are identified as cellular receptors for lysophosphatidic...
2nd June, 2009
Department of Veterinary Internal Medicine, College of Veterinary Mol Biol Rep. 2009 Apr;36(4):751-6. Epub 2008 Apr 1.
DOI Direct Link
Analysis of lysophosphatidic acid (LPA) receptor and LPA-induced endometrial prostaglandin-endoperoxide synthase 2 expression in the porcine uterus.
Lysophosphatidic acid (LPA), a simple phospholipid-derived mediator with...
1st April, 2009
Department of Biological Resources and Technology, Yonsei University, Endocrinology. 2008 Dec;149(12):6166-75. Epub 2008 Aug 14.
DOI Direct Link
[Vector construction and silencing effect of Edg4 gene targeted small interfering RNA in ovarian cancer cell line]
OBJECTIVE: To construct the recombinant eukaryotic expression vector...
27th January, 2009
Department of Obstetrics and Gynecology, the First Affiliated Hospital of Zhonghua Fu Chan Ke Za Zhi. 2007 Nov;42(11):765-9.
[Expression and significance of Edg4 and Edg7 in the placentas of patients with hypertensive disorder complicating pregnancy]
OBJECTIVE: To study Edg4 and Edg7 expression in placenta of women with...
11th October, 2008
Department of Gynecology and Obstetrics, the First Affiliated Hospital of Zhonghua Fu Chan Ke Za Zhi. 2007 Jun;42(6):386-9.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7572811 Immunosuppressant compounds and compositions
7141383 EDG8 receptor, its preparation and use
7063966 Chimeric G protein coupled receptors
7060697 Immunosuppressant compounds and compositions
7052850 Isolated human EDG-4 receptor

View more patents.

EDG4 results (if any) from reagent suppliers

Google CSE Logo
EDG-4 (H-55) Antibody sc-25490
EDG-4 shRNA (h) Lentiviral Particles, sc-39926-V, 200 µl ... EDG-4 (H-55): sc- 25490. Western blot analysis of EDG-4 expression in BT-20 (A), MDA-MB-231 (B),
...
http://www.scbt.com/datasheet-25490-edg-4-h-55-antibody.html...

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EDG4 antibodies: Signal Transduction > Signaling Pathway > G ...
EDG4 antibodies. ... EDG4 antibody. IHC-P, ICC. Rabbit polyclonal ... EDG4 antibody - Aminoterminal end. IHC-P, WB, ELISA. Images. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=76618&pt=1&c=2191&ei=&mu=r...

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EDG-4 (C-16) Antibody sc-16082
EDG-4 shRNA (h) Lentiviral Particles, sc-39926-V, 200 µl ... See how others have used EDG-4 (C-16): sc-16082 antibody and or EDG-4 (C-16) antibody ...
http://www.scbt.com/datasheet-16082-edg-4-c-16-antibody.html...

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Orbigen Inc. - Orbigen Inc.
The integral membrane protein endothelial differentiation sphingolipid G-protein -coupled receptor 4 (EDG4) is a lysophosphatidic acid (LPA) receptor from a ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

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EDG-4 Antibody / EDG-4 Antibodies
EDG-4 Antibody / EDG-4 Antibodies. ... EDG-4 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-edg-4.html...

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Monoclonal Anti-LPA2, N-Terminal antibody produced in mouse (E3141 ...
(EDG-4), N-Terminal protein from human tissue by immunoblotting (45 kDa). The antibody does not ... LPA2, also known as EDG-4, belongs to a family of ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/Datashee...

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EDG4 (LPA2) Functional Receptor Membrane Preparation
27 Jan 2003 ... EDG-4 belongs to a family of G-protein coupled receptors whose ... G-protein coupled EDG4 receptors. NOTE: The protocol below has been ...
http://www.exalpha.com/pdfs/X1546MP.pdf...

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