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ACVR2A
Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16380996 |
Observational study of gene-disease association. (HuGE Navigator) |
| 18001154 |
Inhibin/activin BA subunit, follistatin, and activin receptor proteins and mRNAs are present in the human fetal palate. |
| 16672363 |
structure of the ternary complex representing the signaling competent complex of BMP-2 bound to the entire extracellular domains of both its type I receptor, BMPR-Ia, & its type II receptor, ActRII, at a resolution of 2.2 angstroms |
| 14738881 |
Data indicate that activin A and activin receptors IIA and IIB may be involved in the regulation of germ cell proliferation in the human ovary during the period leading up to primordial follicle formation. |
| 16337854 |
demonstrates that truncating mutations of the ACVR2 gene result in a significant reduction in activin mediated cell signaling. Inactivation of ACVR2 is a common event in prostate cancer and may play an important role in the development of prostate cancer |
| 14691305 |
Activin type II receptor gene (ACTRII) is probably involved in both non-microsattelite unstable and microsattelite-unstable colorectal carcinogenesis, but more frequently in the latter subgroup. |
| 14988818 |
Mutations highly frequent in microsatellite unstable(MSI-H) colon cancers and cause loss of ACVR2, indicating biallelic gene nactivation. Loss of activin signaling through mutation of ACVR2 may have role in genesis of MSI-H colorectal cancer. |
| 17258738 |
Activin is growth suppressive and enhances migration in colon cancer. |
| 17472960 |
RGMa facilitates the use of ActRIIA by endogenous BMP2 and BMP4 ligands that otherwise prefer signaling via BMPRII and that increased utilization of ActRIIA leads to generation of an enhanced BMP signal |
| 12667445 |
crystal structure of BMP7 in complex with the extracellular domain (ECD) of the activin type II receptor | →View more information from publications. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | Activin receptor like kinase 4 | activin A receptor, type IIA precursor | - | - | Pubmed |
| HPRD | activin A type IB receptor isoform a precursor | Activin A receptor, type II | - | - | Pubmed |
| HPRD | Activin A receptor, type II | bone morphogenetic protein 7 precursor | - | - | Pubmed |
| HPRD | Activin A receptor, type II | growth differentiation factor 9 precursor | - | - | Pubmed |
| HPRD | Activin A receptor, type II | membrane associated guanylate kinase, WW and PDZ domain containing 2 | - | - | Pubmed |
| HPRD | Activin A receptor, type II | synaptojanin 2 binding protein | - | - | Pubmed |
| HPRD | activin A receptor, type IIA precursor | Bone morphogenetic protein 7 | - | - | Pubmed |
| HPRD | activin A receptor, type IIA precursor | Growth differentiation factor 9 | - | - | Pubmed |
| HPRD | activin A receptor, type IIA precursor | endoglin isoform 2 precursor | - | - | Pubmed |
| HPRD | activin A receptor, type IIA precursor | endoglin isoform 2 precursor | - | - | Pubmed |
Recent Publications on ACVR2A: |  |
SelTarbase, a database of human mononucleotide-microsatellite mutations and their potential impact to tumorigenesis and immunology.
About 15% of human colorectal cancers and, at varying degrees, other tumor... | 13th October, 2009
| Institute for Clinical Chemistry, Medical Faculty of Mannheim of the
| Nucleic Acids Res. 2009 Oct 9.
DOI Direct Link |
Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation.
Bone tissue arises from mesenchymal cells induced into the osteoblast... | 14th July, 2009
| Department of Cell Biology and Cancer Center, University of Massachusetts
| J Biol Chem. 2009 Jun 5;284(23):15676-84. Epub 2009 Apr 2.
DOI Direct Link |
Bone morphogenetic protein 6 (BMP6) and BMP7 inhibit estrogen-induced proliferation of breast cancer cells by suppressing p38 mitogen-activated protein kinase activation.
Estrogen is involved in the development and progression of breast cancer.... | 11th July, 2009
| Department of Cancer and Thoracic Surgery, Okayama University Graduate
| J Endocrinol. 2008 Dec;199(3):445-55. Epub 2008 Sep 9.
DOI Direct Link |
Genetic association of the activin A receptor gene (ACVR2A) and pre-eclampsia.
Pre-eclampsia is a common serious disorder of human pregnancy, which is... | 9th May, 2009
| Department of Perinatal Medicine and University of Melbourne Department of
| Mol Hum Reprod. 2009 Mar;15(3):195-204. Epub 2009 Jan 6.
DOI Direct Link |
Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study).
Genome-wide scans in Icelandic, Australian/New Zealand and Finnish... | 21st February, 2009
| Department of Cancer Research and Molecular Medicine, Norwegian University
| Eur J Hum Genet. 2009 Feb;17(2):250-7. Epub 2008 Sep 10.
DOI Direct Link |
→View more research publications. |
ACVR2A results (if any) from reagent suppliers | 
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Abgent - Phosphorylation Antibodies - Phosphorylation
AP7103a, ACVR2A Antibody (N-term), WB, IHC, E, H .... AP7104a, Activin Receptor Type IIB (ACVR2A/B) Antibody (Center), WB, IHC, E, H ...
http://www.abgent.com/products/category/protein_modification...
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ACTR-IIA (A-24) Antibody sc-130679
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, ACVR2A, 92, 2q22.3, P27037 ...
http://www.scbt.com/datasheet-130679-actr-iia-a-24-antibody....
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Abgent - Cell and Function Antibodies
AP7102cNEW, ACVR1C Antibody (Center E271), WB, E, H. AP7103a, ACVR2A Antibody (N -term), WB, IHC, E, H. AP7105a, ACVR2B Antibody (N-term), WB, IHC, E, H ...
http://www.abgent.com/products/category/cell_function...
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Activin Receptor Type IIA antibody (ab71521) | Abcam
ab71521, at a 1/50 dilution, staining Activin receptor type II (ACVR2A) in formalin fixed, paraffin embedded human breast carcinoma tissue by ...
http://www.abcam.com/activin-receptor-type-ii-antibody-ab715...
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ACTR-II (D-15) Antibody sc-5669
Souris, Acvr2a, 11480, 2 C1.1, P27038, Non disponible. Souris, Acvr2a, 11480, 2 C1.1, P27038, Non disponible. Souris, Acvr2b, 11481, 9 F3, P27040 ...
http://www.scbt.com/fr/datasheet-5669-actr-ii-d-15-antibody....
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Activin Receptor Type IIA antibody [149/1] - BSA and Azide free ...
Recombinant intracellular kinase domain of the human type 2 activin A receptor ( ACVR2A). Reacts with (species key). Hu. Tested applications (see key) ...
http://www.abcam.com/Activin-Receptor-type-II-antibody-149-1...
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IS EASY
ACVR2A. ULight-Histone H3 (Thr3; 9.4). Carna Biosciences. 09-131. ACVRL1 (ALK1). ULight-Topo IIa (5.6). ULight-PLK (5.4). Invitrogen ...
http://las.perkinelmer.com/content/Manuals/GDE_LANCEUltraSer...
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