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CD4


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Gene DB Home
Symbol:CD4
Name(s):CD4 molecule
Type:protein-coding
Organism:Homo sapiens
Synonyms:CD4mut
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18061610 Vaccination-induced HBsAg-specific CD4 T cell responsed can be measured with the use of an interferon-gamma staining assay.
18156204 there is an enrichment of both IL-17+CD4+ and CD8+ T cells in active multiple sclerosis lesions
18045872 Detection of conformational changes within sCD4 as a result of ligand binding was followed by SAXS on sCD4 bound to two different glycoprotein ligands: the tick saliva immunosuppressor Salp15 and the HIV-1 envelope protein gp120.
17543960 Human CD4(+)CD25(bright) T cells play a major role in tolerating conceptus antigens and therefore may contribute to the maintenance of pregnancy.
17653867 Results suggest that Siva-1 might participate in the CD4-initiated signaling apoptotic pathway induced by the HIV-1 envelope in T-lymphoid cells.
18261176 Campath-1H (Alemtuzumab) is an effective immunodepletion agent used in renal transplantation which increass CD4 regulatory T cells.
11140838 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
15063762 Observational study of gene-disease association. (HuGE Navigator)
15317218 Observational study of genotype prevalence. (HuGE Navigator)
17020785 Observational study of gene-disease association. (HuGE Navigator)

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDHuman T-cell surface antigen CD2 mRNA, and translated productsCD4 antigen precursor--Pubmed
HPRDHuman T-cell surface antigen CD2 mRNA, and translated productsCD4 antigen precursor--Pubmed
HPRDCD4chemokine ligand 12 isoform beta--Pubmed
HPRDT cell surface glycoprotein CD4chemokine ligand 12 isoform beta--Pubmed
HPRDCD4cathepsin D preproprotein--Pubmed
HPRDCD4tumor necrosis factor receptor superfamily, member 10a--Pubmed
HPRDCD4PTK2 protein tyrosine kinase 2 isoform b--Pubmed
HPRDT cell surface glycoprotein CD4PTK2 protein tyrosine kinase 2 isoform b--Pubmed
HPRDCD4 antigen precursorDeath receptor 4--Pubmed
HPRDCD4 antigen precursorFAK--Pubmed

Recent Publications on CD4:

Pubmed Logo
CD4(+)CD25(+) Treg induction by an HSP60-derived peptide SJMHE1 from Schistosoma japonicum is TLR2 dependent.
Chronic schistosome infection results in the suppression of host immune...
3rd November, 2009
Department of Pathogen Biology & Immunology, Department of Pharmacology, Eur J Immunol. 2009 Oct 30;39(11):3052-3065.
DOI Direct Link
In this issue.
COVER IMAGE: This issue's cover features a composite of images showing...
3rd November, 2009
Eur J Immunol. 2009 Oct 30;39(11):2942-2943.
DOI Direct Link
T cell-intrinsic role of Nod2 in promoting type 1 immunity to Toxoplasma gondii.
Nod2 belongs to the nucleotide-binding oligomerization domain receptor...
3rd November, 2009
Department of Pathology and Comprehensive Cancer Center, University of Nat Immunol. 2009 Nov 1.
DOI Direct Link
Requirement for the basic helix-loop-helix transcription factor Dec2 in initial T(H)2 lineage commitment.
How naive CD4(+) T cells commit to the T helper type 2 (T(H)2) lineage is...
3rd November, 2009
Department of Immunology, MD Anderson Cancer Center, Houston, Texas, USA. Nat Immunol. 2009 Nov 1.
DOI Direct Link
Suppressive effects of T-412, a flavone on interleukin-4 production in T cells.
Interleukin (IL)-4 has been suggested as a molecular therapeutic target to...
3rd November, 2009
Lab of Pathology, College of Oriental Medicine, Daejeon University, Biol Pharm Bull. 2009 Nov;32(11):1875-9.

View more research publications.

Press Releases on CD4:

BioPortfolio Logo
Sangamo BioSciences Provides Update on Phase 1 Safety Trial of SB-728-T for HIV/AIDS 18th November, 2009 Sangamo BioSciences, Inc.

RICHMOND, Calif., Nov. 18 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today that data from the University of Pennsylvania investigator sponsored Phase 1

Zyomyx Point-of-Care CD4 Test Selected by CD4 Initiative to Help Treat HIV/AIDS Patients in Developing Countries 17th November, 2009 Zyomyx, Inc.

HAYWARD, Calif., Nov. 17 /PRNewswire/ -- Zyomyx, Inc., a leader in chip-based bioanalysis technologies, today announced that its

Reportlinker Adds Monoclonal Antibody Therapies 2007: Competitive Landscape and Pipeline Insight 5th November, 2009 Reportlinker

NEW YORK, Nov. 5 /PRNewswire/ -- Reportlinker.com announces that a new market research report is available in its catalogue.

Sangamo BioSciences Research Collaborators Awarded Grant From California Institute for Regenerative Medicine to Develop Zinc Finger Nuclease-Based Stem Cell Therapy for HIV/AIDS

28th October, 2009 Sangamo BioSciences, Inc.

RICHMOND, Calif. Oct. 28 /PRNewswire-FirstCall/ -- Sangamo BioSciences, Inc. (Nasdaq: SGMO) announced today that the California Institute for Regenerative Medicine (CIRM) has

Tolerx Presents Otelixizumab Phase 2 Dose Optimization Data At The IDF's 20th World Diabetes Congress 21st October, 2009 Tolerx, Inc.

MONTREAL, Oct. 21 /PRNewswire/ -- Tolerx, Inc., a biopharmaceutical company developing novel therapies intended to treat diabetes, other autoimmune diseases and cancer by

BioNews Results for CD4

: RSS Logo
BioPortfolio Logo
1-Tea May Offer Treatment to Fight HIV
PakTribune.com:  Nov 14 2009 7:03PM Matching: cd4
Hodgkin Lymphoma, Liver Cancer, Anal Cancer More Common With HIV
National AIDS Treatment Advocacy Project:  Nov 13 2009 10:45PM Matching: cd4
Mortality High With Non-AIDS Cancers in EuroSIDA Despite HAART
National AIDS Treatment Advocacy Project:  Nov 13 2009 10:44PM Matching: cd4
Good Neurocognitive Performance Measured by the International HIV Dementia Scale in Early HIV-1 Infection
JAIDS:  Nov 13 2009 2:20AM Matching: cd4
Hepatitis C Viral Kinetics During Treatment With Peg IFN-alpha-2b in HIV/HCV Coinfected Patients as a Function
JAIDS:  Nov 13 2009 2:21AM Matching: cd4
Promote your company here: BioNewsCast - Press Release Distribution

View more news.

Clinical Trials:

Clinical Trials Logo
Interleukin-7 (CYT107) Treatment of Idiopathic CD4 Lymphocytopenia: Expansion of CD4 T Cells (ICICLE)

Patents:

Patents logo
US Patent No.Title
7608265 Treatment for bacterial infections
7608681 Methods and compositions for prolonging elimination half-times of bioactive compounds
7608683 Stress proteins and peptides and methods of use thereof
7608685 Tumor antigen based on products of the tumor suppressor gene WT1
7608686 Human tumor necrosis factor receptor

View more patents.

CD4 results (if any) from reagent suppliers

Google CSE Logo
CD4 Antibody / CD4 Antibodies
CD3 chains and the CD4 or CD8 co-receptors are also required for efficient signal transduction through the TCR. The TCR is expressed on T helper and T ...
http://www.scbt.com/table-cd4.html...

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The Abcam catalog
CD4 antibodies. ... CD4 antibodies beginning with A - C. A - C D - Z. A - C page : 1 2 ... CD4 antibody [74-12-4]. Flow Cyt, IP. Mouse monoclonal ...
http://www.abcam.com/index.html?t=13&pt=1&c=499...

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mouse CD4 antibody: purified monoclonal antibody against L3T4 antigen
eBioscience technical data sheet for product 14-0041 Affinity Purified anti- mouse CD4 (L3T4) GK1.5 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_14/14-...

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Anti-CD4 Monoclonal Antibody
Monoclonal Antibody against CD4 for use in Immunohistochemistry (Paraffin)
http://www.bioreagents.com/products/productDetails/productDe...

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CD4 (MT310) Antibody sc-19641
See how others have used CD4 (MT310): sc-19641 antibody and or CD4 (MT310) antibody ... Western blot analysis of CD4 expression in SUP-T1 whole cell lysate
. ...
http://www.scbt.com/datasheet-19641-cd4-mt310-antibody.html...

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Anti-CD4 Monoclonal Antibody
Monoclonal Antibody against CD4 for use in Flow Cytometry.
http://www.bioreagents.com/products/productDetails/productDe...

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mouse CD4 antibody, Fluorescein isothiocyanate (FITC) conjugate
eBioscience technical data sheet for product 11-0041 FITC anti-mouse CD4 (L3T4) GK1.5 antibody.
http://www.ebioscience.com/ebioscience/specs/antibody_11/11-...

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