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CD5


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Gene DB Home
Symbol:CD5
Name(s):CD5 molecule
Type:protein-coding
Organism:Homo sapiens
Synonyms:LEU1, T1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
15981803 Observational study of gene-disease association. (HuGE Navigator)
18006695 Observational study of gene-disease association. (HuGE Navigator)
17585360 a decrease in CD22(+) B cells and increase in CD5(+)CD22(-) B cells play critical roles in the pathogenesis of RA mediated by the activation of B cells
17878328 support a model where chronic lymphocytic leukemia cells are chronically stimulated, leading to CD5 activation and cell survival
17513730 T lymphocyte activation-induced cell death (AICD) in response to a cognate tumor is inversely proportional to the surface expression level of CD5.
12447961 CD5-negative, CD10-negative small B-cell leukemia: variant of chronic lymphocytic leukemia or a distinct entity
11869933 multiple somatic mutations in human cancers. the value of the CD5 microsatellite as a marker for instability in different tumor types, particularly in B-cell leukemia and lymphoma.
15981803 The polymorphic CD5 promoter is associated with increased susceptibility to B-cell chronic lymphocytic leukemia and mantle cell lymphoma.
11751967 CD5-negative regulation of B cell receptor signaling originates from tyrosine residue Y429 outside an immunoreceptor tyrosine-based inhibitory motif
17325858 CD5 does not inhibit properly the BCR-mediated signaling in leukemic cells.

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCBLCD5 molecule--Pubmed
HPRDHuman T-cell surface antigen CD2 mRNA, and translated productsCD5 molecule--Pubmed
HPRDHuman T-cell surface antigen CD2 mRNA, and translated productsCD5 molecule--Pubmed
HPRDT-cell receptor zeta chain isoform 1 precursorCD5 molecule--Pubmed
HPRDT-cell receptor zeta chain isoform 1 precursorCD5 molecule--Pubmed
HPRDCD4 antigen precursorCD5 molecule--Pubmed
HPRDCD4 antigen precursorCD5 molecule--Pubmed
HPRDCD5dynein, light chain, Tctex-type 3--Pubmed
HPRDCD5CD6 molecule--Pubmed
HPRDCD5 moleculePhosphatidylinositol 3 kinase regulatory subunit, alpha--Pubmed

Recent Publications on CD5:

Pubmed Logo
Immune changes in post-menopausal osteoporosis: the Immunos study.
The phenotypic and functional characteristics of immune cells of...
31st October, 2009
Service de Rhumatologie, CHU de Nice, Hopital l'Archet, Route Saint Osteoporos Int. 2009 Oct 30.
DOI Direct Link
Immunoarchitectural patterns in nodal marginal zone B-cell lymphoma: a study of 51 cases.
Nodal marginal zone lymphoma (NMZL) represents a rare and heterogeneous...
30th October, 2009
Department of Pathology, Stanford University School of Medicine, Stanford, Am J Clin Pathol. 2009 Jul;132(1):39-49.
DOI Direct Link
De novo CD5+ diffuse large B-cell lymphoma: a distinct subset with adverse features, poor failure-free survival and outcome with conventional therapy.
Nodal marginal zone lymphoma (NMZL) represents a rare and heterogeneous...
30th October, 2009
Department of Lymphoma/Myeloma, The University of Texas M.D. Anderson Leuk Lymphoma. 2009 Oct 28.
Isolation of malignant B cells from patients with chronic lymphocytic leukemia (CLL) for analysis of cell proliferation: Validation of a simplified method suitable for multi-center clinical studies.
BACKGROUND: Heavy water ((2)H(2)O) labelling of DNA enables the...
27th October, 2009
KineMed, Inc., 5980 Horton Street, Emeryville, CA 94608, USA. Leuk Res. 2009 Oct 23.
DOI Direct Link
Involvement of RhoH GTPase in the development of B-cell chronic lymphocytic leukemia.
RhoH is a hematopoietic-specific, GTPase-deficient member of the Rho...
23rd October, 2009
[1] Division of Experimental Hematology, Cincinnati Children's Hospital Leukemia. 2009 Oct 22.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Lenalidomide in Comb w/Rituximab for Pts w/CD5+/CD20+ Hem Malig Who Relapse/Progress After Rituximab

Patents:

Patents logo
US Patent No.Title
7553453 Assay implementation in a microfluidic format
7569361 Thrombopoietin protein variants
7572436 Thionin as an antineoplastic and immunostimulant
7572772 Soluble CTLA4 mutant molecules
7576068 Administration of TLR7 ligands and prodrugs thereof for treatment of infection by hepatitis C virus

View more patents.

CD5 results (if any) from reagent suppliers

Google CSE Logo
CD5 Antibody / CD5 Antibodies
CD5 Antibody / CD5 Antibodies. ... CD5 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-cd5.html...

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CD5, antibody
CD5 is present on the majority of human T cells. This antigen is also found on the neoplastic cells in all ... MAb LT1 reacts with CD5 antigen (MW 67 kDa). ...
http://www.hytest.fi/product/cd5,-antibody.html...

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CD5 antibody [B19.1] (Allophycocyanin) (ab25279) | Abcam
Rat monoclonal [B19.1] to CD5 (Allophycocyanin). In humans, CD5 is a 55kDa T lymphocyte single chain transmembrane glycoprotein. It is present on all mature
...
http://www.abcam.com/CD5-antibody-B19-1-Allophycocyanin-ab25...

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CD5 (53-7.3) Antibody sc-18912
See how others have used CD5 (53-7.3): sc-18912 antibody and or CD5 ... CD5 (53- 7.3) FITC: sc-18912 FITC. FCM analysis of mouse peripheral blood leukocytes. ...
http://www.scbt.com/datasheet-18912-cd5-53-7-3-antibody.html...

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Anti-CD5 Monoclonal Antibody
Monoclonal Antibody against CD5 for use in Flow Cytometry, Immunohistochemistry (Frozen)
http://www.bioreagents.com/products/productDetails/productDe...

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CD5 (UCH-T2) Antibody sc-1180
See how others have used CD5 (UCH-T2): sc-1180 antibody and or CD5 (UCH-T2) ... Natural phosphorylation of CD5 in chronic lymphocytic leukemia B cells and ...
http://www.scbt.com/datasheet-1180-cd5-uch-t2-antibody.html...

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Alexa Fluor 488 Anti-human CD5 Antibody Anti-CD5 - BioLegend
Alexa Fluor 488 Anti-human CD5 Antibody Anti-CD5 - CD5 is a 67 kD single chain type I glycoprotein also known as Leu-1, Ly-1 and T1.
http://www.biolegend.com/alexa-fluor-488-anti-human-cd5-anti...

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