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VAPB
| Symbol: | VAPB | | Name(s): | VAMP (vesicle-associated membrane protein)-associated protein B and C | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16729899 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17947296 |
DVAP-33A and hVAPB are functionally interchangeable and transgenic expression of mutant DVAP-33A in neurons recapitulates major hallmarks of the human diseases including locomotion defects, neuronal death and aggregate formation. |
| 17540579 |
P56S mutation in VAP-B may lead to a less stable interaction of this endoplasmic reticulum protein with at least two other proteins: tubulin and GAPDH. |
| 17804640 |
VAPB is abundant in motor neurons and the P56S substitution causes aggregation of mutant VAPB in immobile tubular ER clusters, perturbs FFAT-motif binding, and traps endogenous VAP in mutant aggregates, which may cause motor neuron degeneration. |
| 17536055 |
it is suggested that VAPB mutations do not significantly contribute to the genetic causes of sporadic amyotrophic lateral sclerosis in the UK and Northern Europe |
| 16729899 |
Frequency of the detected exon variation in the VAPB gene was not significantly different between patients and controls. VAPB mutations are not a common cause of adult-onset sporadic amyotrophic lateral sclerosis. |
| 16891305 |
Overexpression of wild type VAPB promotes unfolded protein response, which is a reaction of the endoplasmic reticulum to suppress accumulation of misfolded proteins. |
| 15545272 |
evidence that Nir (Nir1, Nir2, and Nir3)-VAP-B interactions are mediated through the conserved FFAT (two phenylalanines (FF) in acidic tract) motif present in Nir proteins |
| 16571669 |
Regulation of ceramide transport protein by oxyste rbinding proteins, sterols, and VAMP reveals a novel mechanism for integrating sterol regulatory signals with ceramide transport and sphingomyelin synthesis in the Golgi apparatus. |
Recent Publications on VAPB: |  |
Amyotrophic lateral sclerosis mutant VAPB transgenic mice develop TDP-43 pathology.
Cytoplasmic ubiquitin-positive inclusions containing TAR-DNA-binding... | 2nd March, 2010
| MRC Centre for Neurodegeneration Research, Institute of Psychiatry, King's
| Neuroscience. 2010 Feb 23.
DOI Direct Link |
A VAPB mutant linked to amyotrophic lateral sclerosis generates a novel form of organized smooth endoplasmic reticulum.
VAPB (vesicle-associated membrane protein-associated protein B) is an... | 17th December, 2009
| *Consiglio Nazionale delle Ricerche Institute of Neuroscience, Milan,
| FASEB J. 2009 Dec 14.
DOI Direct Link |
Human VAP-C negatively regulates hepatitis C virus propagation.
Human vesicle-associated membrane protein-associated protein (VAP) subtype... | 9th September, 2009
| Department of Molecular Virology, Research Institute for Microbial
| J Virol. 2009 Aug;83(16):7959-69. Epub 2009 Jun 10.
DOI Direct Link |
The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation.
The largest family of bacterial toxin-antitoxin (TA) modules is formed by... | 16th July, 2009
| Department of Microbiology and Immunology, University of Otago, Dunedin,
| J Mol Biol. 2009 Jul 17;390(3):353-67. Epub 2009 May 13.
DOI Direct Link |
Ectopic production of VapCs from Enterobacteria inhibits translation and trans-activates YoeB mRNA interferase.
Toxin-antitoxin loci have been identified in almost all free-living... | 11th July, 2009
| Centre for Bacterial Cell Biology, Institute for Cell and Molecular
| Mol Microbiol. 2009 May;72(4):918-30. Epub 2009 Apr 14.
DOI Direct Link |
→View more research publications. |
VAPB results from Abnova |  | Sponsored Results: |
| VAPB purified MaxPab rabbit polyclonal antibody (D03P)
Rabbit polyclonal antibody raised against a full-length human VAPB protein. Symbol: VAPB Alias: ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C
http://www.abnova.com/products/products_detail.asp?catalog_id=H00009217-D03P |  |
| VAPB 293T Cell Transient Overexpression Lysate(Denatured)
Symbol: VAPB Alias: ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C
http://www.abnova.com/products/products_detail.asp?catalog_id=H00009217-T02 | |
| VAPB monoclonal antibody (M10), clone 1A2
Mouse monoclonal antibody raised against a partial recombinant VAPB. Symbol: VAPB Alias: ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C
http://www.abnova.com/products/products_detail.asp?catalog_id=H00009217-M10 | |
| VAPB MaxPab mouse polyclonal antibody (B02)
Mouse polyclonal antibody raised against a full-length human VAPB protein. Symbol: VAPB Alias: ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C
http://www.abnova.com/products/products_detail.asp?catalog_id=H00009217-B02 | |
| VAPB purified MaxPab mouse polyclonal antibody (B02P)
Mouse polyclonal antibody raised against a full-length human VAPB protein. Symbol: VAPB Alias: ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C
http://www.abnova.com/products/products_detail.asp?catalog_id=H00009217-B02P | |
| VAPB purified MaxPab mouse polyclonal antibody (B01P)
Mouse polyclonal antibody raised against a full-length human VAPB protein. Symbol: VAPB Alias: ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C
http://www.abnova.com/products/products_detail.asp?catalog_id=H00009217-B01P | |
→Search for VAPB products at Abnova. |
VAPB results (if any) from reagent suppliers | 
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VAPB antibody (ab72470) | Abcam
Rabbit polyclonal to VAPB. VAPB contains 1 MSP domain and it may play a role in vesicle trafficking. Defects in VAPB are a cause of proximal adult autosomal ...
http://www.abcam.com/VAPB-antibody-ab72470.html...
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VAP-B/C (K-16) Antibody sc-48702
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, VAPB, 9217, 20q13.32, NM_004738 ...
http://www.scbt.com/datasheet-48702-vap-b-c-k-16-antibody.ht...
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VAPB antibodies: Signal Transduction > Protein Trafficking ...
VAPB antibodies. ... VAPB antibody. IHC-P, WB, IHC-Fr. Rabbit polyclonal. Reacts with: Hu, Ms, Rat. Predicted: Chk, Cow, Xl, Zfsh ...
http://www.abcam.com/index.html?t=55712&pt=1&c=2249&ei=&mu=r...
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HCV Core Antigen antibody, HCV Core Antigen Antibody, Mouse ...
Its interaction with Human VAPB may target the viral replication complex to ... NS5B is a homooligomer and interacts with human VAPB (By similarity). ...
http://www.genwaybio.com/product_info.php?products_id=241825...
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VAMP-1/2 (SP11) Antibody sc-56609
Human, VAPB, 9217, 20q13.32, NM_004738 · O95292 · 608627. Ordering Information. Product Name, Catalog #, Unit, Price, Qty, Wish List. VAMP-1/2 (SP11) ...
http://www.scbt.com/datasheet-56609-vamp-1-2-sp11-antibody.h...
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VAMP2 antibody, VAMP2 Antibody, Rabbit Polyclonal Antibody
Subunit: Interacts with VAPA and VAPB. Subcellular Location: Cytoplasmic vesicle , secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane ...
http://www.genwaybio.com/product_info.php?products_id=196664...
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VAP-B/C siRNA (m) sc-61771
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Mouse, Vapb, 56491, 2 H4, Q9QY76 ...
http://www.scbt.com/datasheet-61771-vap-b-c-sirna-m.html...
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