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VAPB
| Symbol: | VAPB | | Name(s): | VAMP (vesicle-associated membrane protein)-associated protein B and C | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | ALS8, VAMP-B, VAMP-C, VAP-B, VAP-C | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 16729899 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17947296 |
DVAP-33A and hVAPB are functionally interchangeable and transgenic expression of mutant DVAP-33A in neurons recapitulates major hallmarks of the human diseases including locomotion defects, neuronal death and aggregate formation. |
| 17540579 |
P56S mutation in VAP-B may lead to a less stable interaction of this endoplasmic reticulum protein with at least two other proteins: tubulin and GAPDH. |
| 17804640 |
VAPB is abundant in motor neurons and the P56S substitution causes aggregation of mutant VAPB in immobile tubular ER clusters, perturbs FFAT-motif binding, and traps endogenous VAP in mutant aggregates, which may cause motor neuron degeneration. |
| 17536055 |
it is suggested that VAPB mutations do not significantly contribute to the genetic causes of sporadic amyotrophic lateral sclerosis in the UK and Northern Europe |
| 16729899 |
Frequency of the detected exon variation in the VAPB gene was not significantly different between patients and controls. VAPB mutations are not a common cause of adult-onset sporadic amyotrophic lateral sclerosis. |
| 16891305 |
Overexpression of wild type VAPB promotes unfolded protein response, which is a reaction of the endoplasmic reticulum to suppress accumulation of misfolded proteins. |
| 15545272 |
evidence that Nir (Nir1, Nir2, and Nir3)-VAP-B interactions are mediated through the conserved FFAT (two phenylalanines (FF) in acidic tract) motif present in Nir proteins |
| 16571669 |
Regulation of ceramide transport protein by oxyste rbinding proteins, sterols, and VAMP reveals a novel mechanism for integrating sterol regulatory signals with ceramide transport and sphingomyelin synthesis in the Golgi apparatus. |
Recent Publications on VAPB: |  |
Human VAP-C negatively regulates hepatitis C virus propagation.
Human vesicle-associated membrane protein-associated protein (VAP) subtype... | 9th September, 2009
| Department of Molecular Virology, Research Institute for Microbial
| J Virol. 2009 Aug;83(16):7959-69. Epub 2009 Jun 10.
DOI Direct Link |
The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation.
The largest family of bacterial toxin-antitoxin (TA) modules is formed by... | 16th July, 2009
| Department of Microbiology and Immunology, University of Otago, Dunedin,
| J Mol Biol. 2009 Jul 17;390(3):353-67. Epub 2009 May 13.
DOI Direct Link |
Ectopic production of VapCs from Enterobacteria inhibits translation and trans-activates YoeB mRNA interferase.
Toxin-antitoxin loci have been identified in almost all free-living... | 11th July, 2009
| Centre for Bacterial Cell Biology, Institute for Cell and Molecular
| Mol Microbiol. 2009 May;72(4):918-30. Epub 2009 Apr 14.
DOI Direct Link |
ER stress and unfolded protein response in amyotrophic lateral sclerosis.
Several theories on the pathomechanism of amyotrophic lateral sclerosis... | 3rd June, 2009
| Department of Cell Biology and Neuroscience, School of Medicine, Keio
| Mol Neurobiol. 2009 Apr;39(2):81-9. Epub 2009 Jan 30.
DOI Direct Link |
Molecular characterization of Rhodococcus equi from horse-breeding farms by means of multiplex PCR for the vap gene family.
This study evaluated the molecular characteristics of Rhodococcus equi... | 15th May, 2009
| Medicina Veteirnaria Preventiva, Universidade Federal de Santa Maria,
| Curr Microbiol. 2009 Apr;58(4):399-403. Epub 2009 Feb 10.
DOI Direct Link |
→View more research publications. |
VAPB results (if any) from reagent suppliers | 
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VAPB antibody (ab72470) | Abcam
Rabbit polyclonal to VAPB. VAPB contains 1 MSP domain and it may play a role in vesicle trafficking. Defects in VAPB are a cause of proximal adult autosomal ...
http://www.abcam.com/VAPB-antibody-ab72470.html...
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VAP-B/C (K-16) Antibody sc-48702
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, VAPB, 9217, 20q13.32, NM_004738 ...
http://www.scbt.com/datasheet-48702-vap-b-c-k-16-antibody.ht...
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Abcam antibodies and reagents product map
... Tmem27 antibodies (1) · Tmem27 proteins and peptides (1) · Tuberin antibodies (12) · Tuberin proteins and peptides (3) · VAPB antibodies (2) ...
http://www.abcam.com/index.html?cl=2105&pageconfig=productma...
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VAMP-1/2 (SP11) Antibody sc-56609
Human, VAPB, 9217, 20q13.32, NM_004738 · O95292 · 608627. 주문정보. 제품명, 카탈로그 번호, 단위, 가격, 수량, 관심상품. VAMP-1/2 (SP11), sc-56609, 200 µg/ml
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http://www.scbt.com/ko/datasheet-56609-vamp-1-2-sp11-antibod...
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VAP-B/C (K-16) Antibody sc-48702
Spezies, Gen, Gen ID, Chromosomaler Locus, mRNA (Isoform) Accession #, Protein Accession #, OMIM™ Nummer. Human, VAPB, 9217, 20q13.32, NM_004738 · O95292 ...
http://www.scbt.com/de/datasheet-48702-vap-b-c-k-16-antibody...
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VAP-B/C (N-12) Antibody sc-48703
Humain, VAPB, 9217, 20q13.32, NM_004738 · O95292 · 608627. Souris, Vapb, 56491, 2 H4, Q9QY76, Non disponible. Produits disponibles ...
http://www.scbt.com/fr/datasheet-48703-vap-b-c-n-12-antibody...
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Recent Search Terms used to find this page: VAPB Protein | VAPB Protein | VAMP-associated protein B amyotrophic | vapb ffat | FFAT vapb | vapb vamp | Vesicle-associated membrane protein-associated protein B VAMP-associated protein B VAMP-B | Vesicle-associated membrane protein-associated protein B VAMP-associated protein B VAMP-B | VAPB ALS HMN | .
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