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MAGI1


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Symbol:MAGI1
Name(s):membrane associated guanylate kinase, WW and PDZ domain containing 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:AIP3, BAIAP1, BAP1, MAGI-1, TNRC19, WWP3
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16019084 In vitro binding assays using the partial cDNA as a GST fusion protein confirm the binding to full-length MAGI-1 expressed in HEK293 cells.
15908431 Dll1 is presented on the surface of AJs formed at the apical termini of processes through interaction with MAGI1 to activate Notch on neighboring cells in the developing central nervous system
16339077 MAGI-1 is important for vascular endothelial-cadherin-dependent Rap1 activation upon cell-cell contact.
17191119 MAGI-1 cleavage appears to be an important step in the disassembly of cell-cell contacts during apoptosis.
12042308 interaction with synaptopodin and alpha-actinin-4

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDActinin alpha 4BAI1-associated protein 1--Pubmed
HPRDactinin, alpha 4BAI1-associated protein 1--Pubmed
HPRDbrain-specific angiogenesis inhibitor 1 precursorBAI1-associated protein 1--Pubmed
HPRDbrain-specific angiogenesis inhibitor 1 precursorBAI1-associated protein 1--Pubmed
HPRDAtrophin 1BAI1-associated protein 1--Pubmed
BINDHuman atrophin-1 mRNA, and translated productsBAI1-associated protein 1Atrophin-1 interacts with AIP-3.-Pubmed
HPRDatrophin-1BAI1-associated protein 1--Pubmed
HPRDinterleukin 6 receptor isoform 1 precursorBAI1-associated protein 1--Pubmed
HPRDLow density lipoprotein related protein 2BAI1-associated protein 1--Pubmed
HPRDlow density lipoprotein-related protein 2BAI1-associated protein 1--Pubmed

Recent Publications on MAGI1:

Pubmed Logo
Binding of PDZ proteins to HPV E6 proteins does neither correlate with epidemiological risk classification nor with the immortalization of foreskin keratinocytes.
There is compelling evidence that high-risk human papillomaviruses (HPV)...
6th June, 2009
Universitaetsklinikum Tuebingen, Germany. Virology. 2009 May 10;387(2):380-7. Epub 2009 Mar 14.
DOI Direct Link
Methamphetamine enhances HIV-1 infectivity in monocyte derived dendritic cells.
The US is currently experiencing an epidemic of methamphetamine (Meth) use...
12th May, 2009
Department of Immunology, College of Medicine, Florida International J Neuroimmune Pharmacol. 2009 Mar;4(1):129-39. Epub 2008 Oct 29.
DOI Direct Link
TRIP6, a novel molecular partner of the MAGI-1 scaffolding molecule, promotes invasiveness.
We recently established the critical role of the PTEN/MAGI-1b signalosome...
2nd April, 2009
INSERM U773, Universite FASEB J. 2009 Mar;23(3):916-28. Epub 2008 Nov 18.
DOI Direct Link
Structural basis for controlling the dimerization and stability of the WW domains of an atypical subfamily.
The second WW domain in mammalian Salvador protein (SAV1 WW2) is quite...
17th December, 2008
Systems and Structural Biology Center, RIKEN, Tsurumi, Yokohama 230-0045, Protein Sci. 2008 Sep;17(9):1531-41. Epub 2008 Jun 18.
DOI Direct Link
MAGI-1, a candidate stereociliary scaffolding protein, associates with the tip-link component cadherin 23.
Inner ear hair-cell mechanoelectrical transduction is mediated by a...
19th November, 2008
Department of Otolaryngology-Head and Neck Surgery, Stanford University J Neurosci. 2008 Oct 29;28(44):11269-76.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7595152 Detection of influenza virus
7595151 Methods and compositions for diagnosis and treatment of influenza
7588911 Assays for detecting inhibitors of binding between COX-2 and PDZ proteins
7538183 HPV vaccine comprising peptides from host cell proteins
7399467 Antibodies for oncogenic strains of HPV and methods of their use

View more patents.

MAGI1 results (if any) from reagent suppliers

Google CSE Logo
Antibodies to MAGI-1, MAGI-2, MAGI-3/SLIPR
Antibodies to MAGI-1, MAGI-2, MAGI-3/SLIPR feature article is spotlighted at Sigma-Aldrich online. The MAGUK family of proteins, whose prototypic member is
...
http://www.sigmaaldrich.com/life-science/cell-biology/antibo...

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MAGI-1 (SS-5) Antibody sc-100326
Western blot analysis of MAGI-1 expression in PC-12 whole cell lysate. sc-100326 . MAGI-1 (SS-5): sc-100326. Immunofluorescence staining of ...
http://www.scbt.com/datasheet-100326-magi-1-ss-5-antibody.ht...

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MAGI1 antibodies: Signal Transduction > Cytoskeleton / ECM > Cell ...
MAGI1 antibodies. ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab11473 · MAGI1 antibody. WB. Rabbit polyclonal ...
http://www.abcam.com/index.html?t=69667&pt=1&c=745&ei=&mu=ra...

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MAGI-1 (T-17) Antibody sc-11524
goat polyclonal IgG, 200 µg/ml; epitope mapping within an internal region of MAGI-1 of human origin; recommended for detection of MAGI-1 of human origin by
...
http://www.scbt.com/datasheet-11524-magi-1-t-17-antibody.htm...

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New Product Highlights
related MAGUK proteins were isolated: MAGI-1/BAP1, ... Antibodies to MAGI-1, MAGI-2, Slipr/MAGI-3: Assemblers of ... Immunoblotting with Anti-MAGI-1, ...
http://www.sigmaaldrich.com/etc/medialib/docs/Sigma/General_...

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MAGI-1 siRNA (m) sc-42000
Click here for details. suitable control antibody: MAGI-1 (A-19): sc-11523; sqRT -PCR Primer also available: MAGI-1 (m)-PR: sc-42000-PR, 20 µl ...
http://www.scbt.com/datasheet-42000-magi-1-sirna-m.html...

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Purified Anti-PTEN Antibody - BioLegend
PTEN has been shown to interact with phosphatidylinositol 3,4-bisphosphate, PtdIns(3,4,5)P(3), MAGI-1, MAGI-2, MAGI -3, hDLG, and MAST205. ...
http://www.biolegend.com/purified-anti-pten-antibody-2138.ht...

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