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LRAT

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Symbol:	LRAT
Name(s):	lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)
Type:	protein-coding
Organism:	Homo sapiens
Synonyms:	MGC33103
Links:	Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications
Publication Link	Summary of findings
14581364	LRAT expression is higher in renal tumors with an indolent biological behavior
15474300	Results provide evidence that multiple LRAT mRNA transcripts, which are expressed in a tissue-specific manner, may result from differential splicing of the 5'UTR region and the use of multiple polyadenylation signals in the 3'UTR.
17011878	The phenotype of patients with mutations in LRAT is similar to that of patients with mutations in RPE65, suggesting the need to systematically screen both genes in case of typical phenotype.
14596594	Conserved residues Cys-161 and His-60 form the essential catalytic dyad of LRAT that represents a novel thiol protease motif, which functions in an acyltransferase reaction.
16939223	These experiments are consistent with an expanded role for LRAT function as a protein palmitoyl transferase.
15161698	LRAT has a role in preventing progression of invasive bladder cancer
16115871	LRAT has a role in retinoid absorption and storage
17438524	LRAT mutations are likely a rare cause of Leber congenital amaurosis among patients from North America.

Interacting gene products
Interaction Type	Gene 1	Gene 2	Interaction description	Complex	Publication Link
HPRD	RBP1	lecithin retinol acyltransferase	-	-	Pubmed
HPRD	retinol binding protein 1, cellular	Lecithin retinol acyltransferase	-	-	Pubmed
HPRD	Retinol binding protein cellular 2	lecithin retinol acyltransferase	-	-	Pubmed
HPRD	retinol binding protein 2, cellular	Lecithin retinol acyltransferase	-	-	Pubmed
HPRD	lecithin retinol acyltransferase	lecithin retinol acyltransferase	-	-	Pubmed

Recent Publications on LRAT:
Levels, distributions, and source identification of organochlorine pesticides in the topsoils in Northeastern China. Seventeen topsoil samples (9 urban, 4 suburban, 3 rural and 1 background)...	14th January, 2010	International Joint Research Center for Persistent Toxic Substances, State	J Environ Sci (China). 2009;21(10):1386-92.
Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. Tazarotene-induced protein 3 (TIG3) and HRAS-like suppressor family 2...	7th January, 2010	Department of Biochemistry, Kagawa University School of Medicine, 1750-1	Biochim Biophys Acta. 2009 Dec;1791(12):1114-24. Epub 2009 Jul 14. DOI Direct Link
MULTIPLE PATHWAYS ENSURE RETINOID DELIVERY TO MILK: STUDIES IN GENETICALLY MODIFIED MICE. Retinoids are absolutely required for normal growth and development during...	31st December, 2009	1Columbia University.	Am J Physiol Endocrinol Metab. 2009 Dec 29. DOI Direct Link
The 11-cis-retinol dehydrogenase activity of RDH10 and its interaction with visual cycle proteins. PURPOSE: The final step in the retinoid visual cycle is catalyzed by...	16th December, 2009	Department of Cell Biology, University of Oklahoma Health Sciences Center,	Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5089-97. Epub 2009 May 20. DOI Direct Link
Both all-trans retinoic acid and cytochrome P450 (CYP26) inhibitors affect the expression of vitamin A metabolizing enzymes and retinoid biomarkers in organotypic epidermis. The biosynthesis of retinoic acid (RA) from retinol is controlled by...	16th December, 2009	Department of Medical Sciences, Dermatology and Venereology, Uppsala	Arch Dermatol Res. 2009 Aug;301(7):475-85. Epub 2009 Mar 18. DOI Direct Link
→View more research publications.

Press Releases on LRAT:
QLT initiates Phase Ib study of QLT091001 in Leber Congenital Amaurosis	15th December, 2009	QLT Inc.	VANCOUVER, Dec. 15 /PRNewswire-FirstCall/ - QLT Inc. (NASDAQ: QLTI; TSX: QLT) ("QLT" or the "Company") today announced that it has initiated enrollment in a Phase Ib trial of
QLT announces completion of Phase Ia safety trial of its synthetic retinoid product	12th March, 2009	QLT Inc.	VANCOUVER, March 12 /PRNewswire-FirstCall/ - QLT Inc. (NASDAQ: QLTI; TSX: QLT) ("QLT" or the "Company") today announced the results from a Phase Ia trial of QLT091001 in healthy

BioNews Results for LRAT :
QLT initiates Phase Ib study of QLT091001 in Leber Congenital Amaurosis	Montana's News Station: Dec 31 2009 11:20PM Matching: lrat
QLT initiates Phase Ib study of QLT091001 in Leber Congenital Amaurosis	KLFY: Dec 31 2009 11:40AM Matching: lrat
QLT initiates Phase Ib study of QLT091001 in Leber Congenital Amaurosis	KSLA: Dec 26 2009 7:52PM Matching: lrat
QLT begins phase 1b trial of Leber's congenital amaurosis treatment, launches US subsidiary	OSN Super Site: Dec 24 2009 2:43AM Matching: lrat
QLT initiates Phase Ib study of QLT091001 in Leber Congenital Amaurosis	SmartBrief: Dec 16 2009 7:05AM Matching: lrat
Promote your company here: BioNewsCast - Press Release Distribution	→View more news.

Clinical Trials:
A Safety/Proof of Concept Study to Evaluate the Effects of Oral QLT091001 in Children With Leber Congenital Amaurosis (LCA)

Patents:
US Patent No.	Title
7604947	Detection and modulation of cancer stem cells
5756109	Skin care compositions containing geranyl geraniol and retinol or retinyl esters
5759556	Skin care compositions containing certain cyclic aliphatic unsaturated compounds and retinol or retinyl ester
5794024	Method and system for dynamically recovering a register-address-table upon occurrence of an interrupt or branch misprediction
5955092	Skin care compositions containing an n-substituted fatty acid amide and retinol or retinyl ester
→View more patents.

LRAT results from Abnova
Sponsored Results:
	LRAT Pre-design Chimera RNAi Homo sapiens lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) (LRAT), mRNA. Symbol: LRAT Alias: MGC33103 http://www.abnova.com/products/products_detail.asp?catalog_id=H00009227-R01
	LRAT Recombinant Protein (Q01) LRAT( NP_004735.2, 33 a.a. - 132 a.a.) partial recombinant protein with GST tag. Symbol: LRAT Alias: MGC33103 http://www.abnova.com/products/products_detail.asp?catalog_id=H00009227-Q01
	LRAT monoclonal antibody (M01), clone 1A11 Mouse monoclonal antibody raised against a full length recombinant LRAT. Symbol: LRAT Alias: MGC33103 http://www.abnova.com/products/products_detail.asp?catalog_id=H00009227-M01
	LRAT Recombinant Protein (P01) LRAT( AAH31053.1, 1 a.a. - 231 a.a.) full-length recombinant protein with GST tag. Symbol: LRAT Alias: MGC33103 http://www.abnova.com/products/products_detail.asp?catalog_id=H00009227-P01
	LRAT monoclonal antibody (M05), clone 4E12 Mouse monoclonal antibody raised against a partial recombinant LRAT. Symbol: LRAT Alias: MGC33103 http://www.abnova.com/products/products_detail.asp?catalog_id=H00009227-M05
→Search for LRAT products at Abnova.

LRAT results (if any) from reagent suppliers

LRAT Antibody / LRAT Antibodies LRAT Antibody / LRAT Antibodies. ... LRAT specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ... http://www.scbt.com/table-lrat.html...
LRAT antibodies: Neuroscience > Sensory System > Visual system \| Abcam LRAT antibody. IHC-P, WB, ICC/IF. Images · Customer Abreviews: 4 stars (out of 5 ). Rabbit polyclonal. Reacts with: Hu. Predicted: Chmp ... http://www.abcam.com/index.html?t=270506&pt=1&c=3333&ei=&mu=...
LRAT (M-15) Antibody sc-49222 goat polyclonal IgG, 200µg/ml; epitope mapping within an internal region of LRAT of mouse origin; recommended for detection of LRAT of mouse and, ... http://www.scbt.com/datasheet-49222-lrat-m-15-antibody.html...
LRAT antibodies: Signal Transduction > Metabolism > Lipid ... Applications (see key) & Reactivity (see key). Image Abreview Publication. ab73401 · LRAT antibody. WB, ICC/IF. Images. Rabbit polyclonal ... http://www.abcam.com/index.html?t=270506&pt=1&c=3612&ei=&mu=...
LRAT (N-15) Antibody sc-49223 goat polyclonal IgG, 200µg/ml; epitope mapping at the N-terminus of LRAT of human origin; recommended for detection of LRAT of human origin by WB, ... http://www.scbt.com/datasheet-49223-lrat-n-15-antibody.html...
RPE65 antibody (ab13826) \| Abcam The soluble form binds vitamin A (all-trans-retinol), making it available for LRAT processing to all-trans-retinyl ester. The membrane form, palmitoylated ... http://www.abcam.com/RPE65-antibody-ab13826.html...
LRAT (M34-P1F10) Antibody sc-101391 Western blot analysis of LRAT expression in HeLa whole cell lysate. sc-101391. LRAT (M34-P1F10): sc-101391. Immunofluorescence staining of methanol-fixed ... http://www.scbt.com/datasheet-101391-lrat-m34-p1f10-antibody...

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