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PTTG1
| Symbol: | PTTG1 | | Name(s): | pituitary tumor-transforming 1 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | EAP1, HPTTG, MGC126883, MGC138276, PTTG, TUTR1 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18245958 |
Overexpression of gamma-catenin caused an increase in PTTG and c-Myc protein levels, which are likely to accelerate chromosomal instability and uncontrolled proliferation, respectively, in the affected cells. |
| 17210994 |
Observational study of gene-disease association. (HuGE Navigator) |
| 17962814 |
data suggest that securin has a key role in the maintenance of genomic stability after DNA damage, thereby providing a previously unknown mechanism for regulating tumour progression |
| 18047793 |
UV irradiation decreased PTTG1 mRNA and protein expression. These effects were found to be mediated by JNK pathway. |
| 17854787 |
existence of securin promotes apoptosis via a p53-indpendent pathway after radiation in human colorectal cancer cells |
| 17353909 |
Results show that PTTG1 exhibits properties of a global transcription factor, and specifically modulates the G1/S-phase transition by interacting with Sp1. |
| 17507465 |
Data show that overexpression of human pituitary tumor transforming gene cooperated with the HTLV-I Tax oncoprotein in cellular transformation. |
| 17652795 |
PTTG is localized in cytoplasm of pituitary tumor cells. |
| 17071631 |
securin may be a critical gene in the development of genetic instability in colorectal cancer. |
| 12194817 |
Data suggest that separase is required for sister chromatid separation during mitosis in human cells, and that securin inhibits separase by blocking the access of substrates to the active site of separase. | →View more information from publications. |
Recent Publications on PTTG1: |  |
Transcriptional patterns, biomarkers and pathways characterizing nasopharyngeal carcinoma of Southern China.
BACKGROUND: The pathogenesis of nasopharyngeal carcinoma (NPC) is a... | 16th September, 2008
| Cancer Research Institute of Southern Medical University, Key Lab for
| J Transl Med. 2008 Jun 20;6:32.
DOI Direct Link |
Rat prolactinoma cell growth regulation by epidermal growth factor receptor ligands.
Epidermal growth factor (EGF) regulates pituitary development, hormone... | 9th September, 2008
| Department of Medicine, Cedars-Sinai Medical Center, University of
| Cancer Res. 2008 Aug 1;68(15):6377-86.
DOI Direct Link |
Modified cell cycle status in a mouse model of altered neuronal vulnerability (slow Wallerian degeneration; Wlds).
BACKGROUND: Altered neuronal vulnerability underlies many diseases of the... | 30th August, 2008
| Centre for Integrative Physiology, University of Edinburgh Medical School,
| Genome Biol. 2008;9(6):R101. Epub 2008 Jun 20.
DOI Direct Link |
Neurotrophin p75 receptor (p75NTR) promotes endothelial cell apoptosis and inhibits angiogenesis: implications for diabetes-induced impaired neovascularization in ischemic limb muscles.
Diabetes impairs endothelial function and reparative neovascularization.... | 9th August, 2008
| Experimental Cardiovascular Medicine Division, Bristol Heart Institute,
| Circ Res. 2008 Jul 18;103(2):e15-26. Epub 2008 Jun 19.
DOI Direct Link |
Proliferation marker securin identifies favourable outcome in invasive ductal breast cancer.
We introduce a new proliferation marker, securin (pituitary... | 1st August, 2008
| Department of Pathology, Turku University Hospital, University of Turku,
| Br J Cancer. 2008 Jul 22;99(2):335-40. Epub 2008 Jul 1.
DOI Direct Link |
→View more research publications. |
PTTG1 results (if any) from reagent suppliers | 
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HPA008890 Anti PTTG1 antibody produced in rabbit Prestige ...
HPA008890 Anti-PTTG1 antibody produced in rabbit Prestige Antibodies™ Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol ...
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...
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Phospho-ESPL1-pS801 Antibody
First, it is inactivated via its interaction with securin/PTTG1, which probably ... The association with PTTG1 is not only inhibitory, since PTTG1 is also ...
http://www.abgent.com/products/catalog_no/AP3101a/background...
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WH0009232M1 Monoclonal Anti PTTG1 antibody produced in mouse clone ...
WH0009232M1 Monoclonal Anti-PTTG1 antibody produced in mouse clone 1D9, purified immunoglobulin, buffered aqueous solution.
http://www.sigmaaldrich.com/catalog/search/ProductDetail/SIG...
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PTTG1IP antibody (ab68208) datasheet | Abcam
The protein encoded by the PTTG1IP gene, which directly binds to pituitary tumor -transforming gene 1 protein (PTTG1), facilitates the nuclear translocation ...
http://www.abcam.com/index.html?datasheet=68208...
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PTTG1 pituitary tumor-transforming 1
PTTG1; EAP1; HPTTG; MGC126883; MGC138276; PTTG; SECURIN; TUTR1 ... WH0009232M1, Monoclonal Anti-PTTG1 antibody produced in mouse clone 1D9, ...
http://www.sigmaaldrich.com/catalog/search/SIRNASearchGeneDe...
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PTTG (M-16) Antibody sc-5843
Number. Human, PTTG1, 9232, 5q33.3, NM_004219 · O95997 · 604147. Mouse, Pttg1, 30939, 11 A5, Q9CQJ7, N/A. Ordering Information ...
http://www.scbt.com/datasheet-5843-pttg-m-16-antibody.html...
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Securin antibody [DCS-280] (ab3305) datasheet | Abcam
Alternative names: Pituitary Tumor Transforming Gene 1; PTTG1; PTTG; Esp1- associated protein 1; EAP 1; Tumor-Transforming 1; TUTR 1; Securin; Pds 1; Pds 1
. ...
http://www.abcam.com/index.html?datasheet=3305...
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PTTG (SPM210) Antibody sc-56461
ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, PTTG1, 9232, 5q33.3, NM_004219 · O95997 ...
http://www.scbt.com/datasheet-56461-pttg-spm210-antibody.htm...
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Rnai Resources | Imgenex
HDAC and Hsp90 inhibitors down-regulate PTTG1/securin but do not induce aneuploidy. Genes Chromosomes Cancer . 2008 Nov 11. [Epub ahead of print] ...
http://www.imgenex.com/rnai_resources.php...
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SH1831 MISSION shRNA Human Gene Family Set Lentiviral Particles ...
... POLK(51426), POLL(27343), POLN(353497), PRPF19(27339), PTTG1(9232), RAD17( 5884), RAD18(56852), RAD51(5888), RAD51AP1(10635), RAD52(5893), RAD54B(25788),
...
http://www.sigmaaldrich.com/catalog/search/ProductDetail?Pro...
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