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NOG


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Gene DB Home
Symbol:NOG
Name(s):noggin
Type:protein-coding
Organism:Homo sapiens
Synonyms:SYM1, SYNS1
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
18019378 Various mutations may occur in myositis ossificans nuclear families.
12404109 Observational study of gene-disease association. (HuGE Navigator)
17696196 Expression analysis of additional genes, AKT1, NOG and its antagonist BMP4, which interact downstream to FGFR1, demonstrated expression differences between primary rhabdomyosarcoma tumors and normal skeletal muscles
17889703 NOG is involved in myeloproliferative disease associated with myelofibrosis
17200191 Lack of noggin expression by cancer cells may be a relevant mechanism contributing to the osteoblast response in bone metastases
17218603 Antagonism of bone morphogenetic protein signaling by transgenic Noggin plays a critical role in ensuring proper levels of cell proliferation and epithelial-to-mesenchymal transformation during cardiac morphogenesis.
16126463 Overexpression of noggin in PC-3 cells inhibited the expansion of the lesion in vivo.
17138967 Data show calcium-sensing receptor stimulation of T-84 epithelia and colonic myofibroblasts downregulated the BMP family antagonist Noggin.
11857750 A novel NOG gene mutation giving rise to the (P35S) amino acid substitution has been identified in an Italian family with symphalangism.
14999064 Here, we show that the overexpression of human noggin, by acting to inhibit glial differentiation by subependymal progenitor cells, can potentiate adenoviral BDNF-mediated recruitment of new neurons to the adult rat neostriatum

View more information from publications.

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDBone morphogenetic protein 2noggin precursor--Pubmed
HPRDbone morphogenetic protein 2 preproproteinNoggin--Pubmed
HPRDBone morphogenetic protein 4noggin precursor--Pubmed
HPRDbone morphogenetic protein 4 preproproteinNoggin--Pubmed
HPRDBone morphogenetic protein 5noggin precursor--Pubmed
HPRDbone morphogenetic protein 5 preproproteinNoggin--Pubmed
HPRDbone morphogenetic protein 7 precursornoggin precursor--Pubmed
HPRDbone morphogenetic protein 7 precursornoggin precursor--Pubmed

Recent Publications on NOG:

Pubmed Logo
T cell-mediated control of Epstein-Barr virus infection in humanized mice.
Humanized NOD/Shi-scid/interleukin-2Rgamma(null) (NOG) mice with full T...
17th October, 2009
Department of Infectious Diseases, National Research Institute for Child J Infect Dis. 2009 Nov 15;200(10):1611-5.
DOI Direct Link
Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system.
Here we report stable gene transfer in cord blood-derived CD34(+)...
24th September, 2009
Division of Pediatric Blood and Marrow Transplantation, Berlin, Germany. Blood. 2009 Aug 13;114(7):1319-30. Epub 2009 May 4.
DOI Direct Link
ERas is expressed in primate embryonic stem cells but not related to tumorigenesis.
The ERas gene promotes the proliferation of and formation of teratomas by...
23rd September, 2009
Division of Regenerative Medicine, Center for Molecular Medicine, Jichi Cell Transplant. 2009;18(4):381-9.
DOI Direct Link
Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL Cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2Rgamma(null) mice in vivo.
There is a lack of suitable small animal models to evaluate human...
15th September, 2009
Department of Medical Oncology and Immunology, Nagoya City University J Immunol. 2009 Oct 1;183(7):4782-91. Epub 2009 Sep 11.
DOI Direct Link
The analysis of the functions of human B and T cells in humanized NOD/shi-scid/gammac(null) (NOG) mice (hu-HSC NOG mice).
'Humanized mice' are anticipated to be a valuable tool for studying the...
10th September, 2009
Department of Microbiology and Immunology, Tohoku University Graduate Int Immunol. 2009 Jul;21(7):843-58. Epub 2009 Jun 10.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
6863903 Pharmaceutical product comprising anti-secretory protein from egg yolk
7148045 Hybrid polyketide synthases and novel loading domains
7194133 Methods for detecting similarity between images, voices, oscillation waves, moving images, and solids and methods for recovering the image, voice, abnormality in a machine, moving image, and solid by the use of detected value thereof
7198922 Polyketides and their synthesis
7204991 Porphyromonas gingivalis recombinant proteins and truncations

View more patents.

NOG results (if any) from reagent suppliers

Google CSE Logo
NOG antibody, Noggin Antibody, Rabbit Polyclonal Antibody
Buy quality rabbit NOG antibody (interacts with mouse rat), anti-NOG, Noggin antibody, rabbit polyclonal antibody, Noggin Antibody, Rabbit Polyclonal ...
http://www.genwaybio.com/product_info.php?products_id=30117...

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Anti-Noggin Polyclonal Antibody
PA1-4521 detects Noggin (NOG) in human samples. ... This antibody is specific for the ~32 kDa protein representing Noggin (NOG) . ...
http://www.bioreagents.com/products/productDetails/productDe...

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NOG protein, Noggin Human recombinant protein
Buy quality NOG protein (e. coli), NOG, Noggin Human recombinant protein, (n/an/ a). SYM1, SYNS1, NOG.; N/A; Noggin, NOGG_HUMAN [ N/A NP_005441.1 Q13253 ].
http://www.genwaybio.com/product_info.php?products_id=45804...

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Antibodies to Transforming Growth Factor-beta (TGF-beta) and ...
Nog(25495), human, WB, pricing. T1940, Anti-Transforming Growth Factor-β Soluble Receptor III antibody produced in goat, (polyclonal) ...
http://www.sigmaaldrich.com/etc/controller/controller-page.h...

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N4538 Anti-Noggin antibody produced in rabbit ~1 mg/mL, affinity ...
Gene Information, human ... NOG(9241). rat ... Nog(25495). mouse ... Nog(18121). shipped in, dry ice. storage temp. −20°C ...
https://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=N45...

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Noggin (C-18) Antibody sc-16627
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, NOG, 9241, 17q22, NM_005450 · Q13253
...
http://www.scbt.com/datasheet-16627-noggin-c-18-antibody.htm...

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Tenascin C antibody [MTn-12] (ab6346) | Abcam
... confluent mouse mammary epithelial cells cell lines NOG-8, EpH4, Fos-ER and 410.4, HC-11) (Wirl et al), Purified tenascin (Weller et al). ...
http://www.abcam.com/Tenascin-C-antibody-MTn-12-ab6346.html...

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