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EDG5
| Symbol: | EDG5 | | Name(s): | endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 | | Type: | protein-coding | | Organism: | Homo sapiens | | Synonyms: | AGR16, EDG-5, Gpcr13, H218, LPB2, S1P2, S1PR2 | | Links: |
Pubmed,
Entrez Gene,
GeneCards,
BioGPS,
Map Viewer.
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Gene Information from Publications |
| Publication Link |
Summary of findings |
| 18088600 |
These results suggest that S1P(2) receptors/G(12/13)-proteins/Rho signaling pathways mediate S1P-induced inhibition of glioma cell migration. |
| 17710232 |
antagonism of the S1P2R may be a novel therapeutic approach for the prevention and/or treatment of pathologic ocular neovascularization |
| 17431187 |
S1P2R activation in endothelial cells increases vascular permeability. The balance of S1P1 and S1P2 receptors in the endothelium may determine the regulation of vascular permeability by S1P. |
| 11915348 |
suppress rac protein, a Rho family G protein and cell motility |
| 15208267 |
Amyloid beta-protein stimulated in monocytes the gene expression for sphingosine-1-phosphate receptor 5, which is amyloid beta-protein-induced migration. |
| 15764699 |
S1P2R receptor actively regulates the PTEN phosphatase by a Rho GTPase-dependent pathway to inhibit cell migration. |
Interacting gene products |
| Interaction Type |
Gene 1 |
Gene 2 |
Interaction description |
Complex |
Publication Link |
| HPRD | G protein, alpha inhibiting 1 | endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 | - | - | Pubmed |
| HPRD | guanine nucleotide binding protein, alpha inhibiting activity polypeptide 1 | Endothelial differentiation gene 5 | - | - | Pubmed |
| HPRD | Guanine nucleotide binding protein G(q) alpha subunit | endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 | - | - | Pubmed |
| HPRD | guanine nucleotide binding protein, q polypeptide | Endothelial differentiation gene 5 | - | - | Pubmed |
| HPRD | Endothelial differentiation gene 5 | guanine nucleotide binding protein, alpha 13 | - | - | Pubmed |
| HPRD | endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 | Guanine nucleotide binding protein, alpha 13 | - | - | Pubmed |
Recent Publications on EDG5: |  |
Non-Edg family lysophosphatidic acid (LPA) receptors.
Lysophosphatidic acid (LPA; 1- or 2-acyl-sn-glycero-3-phosphate) is a... | 16th June, 2009
| Department of Biochemistry and Molecular Biology, Faculty of Medicine, The
| Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):57-65. Epub 2009 Jun
DOI Direct Link |
Sphingosine-1-phosphate receptors regulate individual cell behaviours underlying the directed migration of prechordal plate progenitor cells during zebrafish gastrulation.
During vertebrate gastrulation, cells forming the prechordal plate undergo... | 17th December, 2008
| Department of Anatomy and Developmental Biology, University College
| Development. 2008 Sep;135(18):3043-51. Epub 2008 Aug 13.
DOI Direct Link |
Sphingosine 1-phosphate triggers apoptotic signal for B16 melanoma cells via ERK and caspase activation.
The bioactive sphingolipid metabolite sphingosine 1-phosphate (S1P),... | 8th June, 2007
| Department of Dermatology, School of Medicine, Inha University, Incheon,
| J Korean Med Sci. 2007 Apr;22(2):298-304.
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Sphingosine-1-phosphate receptor expression and signaling correlate with uterine prostaglandin-endoperoxide synthase 2 expression and angiogenesis during early pregnancy.
Signaling mechanisms coordinating uterine angiogenesis and tissue... | 2nd December, 2005
| Vincent Center for Reproductive Biology, Vincent Obstetrics and Gynecology
| Biol Reprod. 2006 Mar;74(3):569-76. Epub 2005 Nov 30.
DOI Direct Link |
The blockade of cyclopiazonic acid-induced store-operated Ca2+ entry pathway by YC-1 in neutrophils.
In the presence of external Ca2+, pretreatment of neutrophils with... | 26th January, 2005
| Department of Education and Research, Taichung Veterans General Hospital,
| Biochem Pharmacol. 2004 Nov 15;68(10):2053-64.
DOI Direct Link |
→View more research publications. |
EDG5 results (if any) from reagent suppliers | 
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EDG-5 Antibody / EDG-5 Antibodies
EDG-5 Antibody / EDG-5 Antibodies. ... EDG-5 specific siRNA, sHRNA Plasmid and shRNA Lentiviral Particles gene silencers are also available. ...
http://www.scbt.com/table-edg-5.html...
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Polyclonal Antibody to Edg5/S1P2
Endothelial differentiation, sphingolipid G protein coupled receptor, 5, Lysosphingolipid receptor Edg5, S1P receptor EDG5, Sphingosine 1 phosphate
receptor ...
http://www.imgenex.com/antibody_details.php?catalog=IMG-6135...
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EDG-5 (H-64) Antibody sc-25491
EDG-5 shRNA (h) Lentiviral Particles, sc-39928-V, 200 µl ... Western blot analysis of human recombinant EDG-5 fusion protein. Download ...
http://www.scbt.com/datasheet-25491-edg-5-h-64-antibody.html...
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Polyclonal Antibody to Edg5/S1P2
Western blot analysis of S1P2/Edg5 in heart lysate; Lane 1 shows pre-immune sera ; Lanes 2, 3 and 4 show IMG-6135A tested on human ...
http://www.imgenex.com/tds/IMG-6135A.pdf...
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EDG-5 (H-18) Antibody sc-31577
goat polyclonal IgG, 200 µg/ml; epitope mapping within a cytoplasmic domain of EDG-5 of human origin; recommended for detection of EDG-5 of m, ...
http://www.scbt.com/datasheet-31577-edg-5-h-18-antibody.html...
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IMG-6135A : Polyclonal Antibody to Edg5/S1P2 | Imgenex Faq
IMG-6135A [Polyclonal Antibody to Edg5/S1P2]. Go to 'IMG-6135A' Data Sheet. Question : 1. I am unable to get IMG-6135A (Anti-S1P2 Edge5) to work. ...
http://www.imgenex.com/knowledgebase.php?id=8367...
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E4767 Monoclonal Anti-S1P2, C-Terminal antibody produced in mouse ...
The ligand for EDG-5/S1P2 is sphingosine 1-phosphate, and is expressed in cardiovascular, ... Immunogen, human EDG-5/S1P2 unique C-terminal peptide. ...
http://www.sigmaaldrich.com/catalog/ProductDetail.do?N4=E476...
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