BioPortfolio - FTMT - ferritin mitochondrial

FTMT

Symbol:

FTMT

Name(s):

ferritin mitochondrial

Type:

protein-coding

Organism:

Homo sapiens

Synonyms:

MTF

Links:

Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link

Summary of findings

18160053

Frataxin has some roles in controlling the balance between different mitochondrial iron pools that are partially in common with those of mitochondrial ferritin.

17459943

Demonstrated iron uptake by ferritins into multiple organs. Uptake is greater when iron delivered by H-ferritin compared to L-ferritin.

17565989

PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene

12406866

RT-PCR studies showed MtF mRNA in circulating reticulocytes of 2 X-linked sideroblastic anemia patients but not controls. Most of the iron in perinuclear mitochondria of ring sideroblasts is in the form of MtF, a specific marker of sideroblastic anemia.

16797877

functional analysis of an H ferritin promoter allele carrying a G to T substitution adjacent to the Bbf binding site, in position -69

11953424

Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism

15755449

Data reveal striking differences in iron oxidation and hydrolysis chemistry between human mitochondrial ferritin and human H-chain ferritin despite their similar diiron ferroxidase centers.

15065877

In contrast to previously published literature, this study demonstrates that the putative nucleation site does not play an important role in iron uptake or mineralization in H-chain ferritin.

16448386

ferritin H not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance

16537925

These results suggest that hemin activates the transcription of the ferritin H gene during K562 erythroid differentiation by Ref-1-mediated activation of these b-zip transcription factors to the Antioxidant-responsive Elements.

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