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TJP2


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Symbol:TJP2
Name(s):tight junction protein 2 (zona occludens 2)
Type:protein-coding
Organism:Homo sapiens
Synonyms:MGC26306, X104, ZO-2, ZO2
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17217619 Sertoli cells associated with carcinoma in situ of the testicles show an altered distribution of ZO-2 and loss of blood-testis barrier function.
12704386 Familial hypercholanemia in Amish individuals is associated with mutations in tight junction protein 2 (encoded by TJP2, also known as ZO-2) and bile acid Coenzyme A: amino acid N-acyltransferase (encoded by BAAT).

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDCatenin, alpha 1tight junction protein 2 isoform 1--Pubmed
HPRDCatenin alpha 1tight junction protein 2 isoform 1--Pubmed
HPRDcatenin, alpha 1Tight junction protein 2--Pubmed
HPRDHomo sapiens protein 4.1 mRNA, complete cds.tight junction protein 2 isoform 1--Pubmed
HPRDHomo sapiens protein 4.1 mRNA, complete cds.tight junction protein 2 isoform 1--Pubmed
HPRDOccludintight junction protein 2 isoform 1--Pubmed
HPRDoccludinTight junction protein 2--Pubmed
HPRDScaffold Attachment Factor Btight junction protein 2 isoform 1--Pubmed
HPRDtight junction protein 1 isoform atight junction protein 2 isoform 1--Pubmed
HPRDtight junction protein 1 isoform atight junction protein 2 isoform 1--Pubmed

Recent Publications on TJP2:

Pubmed Logo
Monocyte chemoattractant protein-1 in the choroid plexus: a potential link between vascular pro-inflammatory mediators and the CNS during peripheral tissue inflammation.
During peripheral tissue inflammation, inflammatory processes in the CNS...
16th April, 2009
Neurobiology and Pain Therapeutics Section, National Institute of Dental Neuroscience. 2009 Jan 23;158(2):885-95. Epub 2008 Nov 7.
DOI Direct Link
Galpha12 regulates protein interactions within the MDCK cell tight junction and inhibits tight-junction assembly.
The polarized functions of epithelia require an intact tight junction (TJ)...
18th July, 2008
Renal Division, Brigham and Women's Hospital and Harvard Medical School, J Cell Sci. 2008 Mar 15;121(Pt 6):814-24. Epub 2008 Feb 19.
DOI Direct Link
Identification, tissue distribution and developmental expression of tjp1/zo-1, tjp2/zo-2 and tjp3/zo-3 in the zebrafish, Danio rerio.
The tight junction (TJ) or zona occludens (ZO) proteins TJP1/ZO-1,...
8th November, 2007
Epithelial Cell Biology Laboratory, Institute of Molecular and Cell Gene Expr Patterns. 2007 Aug;7(7):767-76. Epub 2007 Jun 6.
DOI Direct Link
Survey of differentially methylated promoters in prostate cancer cell lines.
DNA methylation and copy number in the genomes of three immortalized...
24th December, 2005
Sidney Kimmel Cancer Center, 10835 Road to the Cure, San Diego, CA 92121, Neoplasia. 2005 Aug;7(8):748-60.
Molecular basis of intrahepatic cholestasis.
Intrahepatic cholestasis, or impairment of bile flow, is an important...
9th April, 2005
Liver Center Laboratory and Department of Medicine, San Francisco General Ann Med. 2004;36(8):606-17.

View more research publications.

Patents:

Patents logo
US Patent No.Title
7547687 Therapeutic treatment methods
7485418 Aberrantly methylated genes in pancreatic cancer
7482334 Therapeutic treatment methods
6962989 Corynebacterium glutamicum genes encoding novel proteins
5577009 Tracking control system for generating a variable still jump signal

View more patents.

TJP2 results (if any) from reagent suppliers

Google CSE Logo
ZO-2 (H-110) Antibody sc-11448
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, TJP2, 9414, 9q21.11, NM_004817, ...
http://www.scbt.com/datasheet-11448-zo-2-h-110-antibody.html...

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POLYCLONAL ANTIBODY TO HUMAN ZONA OCCLUDENS 2 (ZO-2)
Tight junction protein 2 (TJP2). Species. Guinea pig Ig. Formulation. 1 ml (100 µg/ml) 0.2 µm filtered antibody solution in PBS, containing 0.1% bovine ...
http://www.hbt.nl/HP9046.pdf...

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Claudin 6 (phospho Y219) antibody (ab78347) | Abcam
Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Alternative names Claudin 6 (phospho Y219) antibody (ab78347). Database links ...
http://www.abcam.com/Claudin-6-phospho-Y219-antibody-ab78347...

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Prestige Antibodies® as Organelle Markers for Sub-cellular ...
Intercellular Junctions HPA001636, Anti-TJP1 HPA001813, Anti-TJP2 Nucleus HPA002844, Anti-FBXO18 HPA000593, Anti-MECP2 HPA001894, Anti-GPKOW ...
http://www.sigmaaldrich.com/life-science/cell-biology/antibo...

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PhosphoSignature™
TJP2. Tight junction protein ZO-2 (Zonula occludens protein 2). Q9UDY2. 134. § 1118. IEIAQKHPDIyAVPIK. 3. 838. 1.9. 1.8-2.0 adhesion proteins. CTNNB1 ...
http://www.cellsignal.com/technologies/phosphoscan/pdfs/PSig...

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Page 1 of BR_In Vitro 5_rz.indd
HPA001813, Anti-TJP2. Nucleus (Figure 2). HPA002844, Anti-FBXO18. HPA000593, Anti-MECP2. HPA001894, Anti-GPKOW. HPA006801, Anti-XRCC4. HPA006104, Anti-MYST4
...
http://www.sigmaaldrich.com/etc/medialib/docs/promo/Brochure...

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Abcam antibodies and reagents product map
... Symplekin antibodies (4) · TJAP1 antibodies (1) · TJP2 antibodies (2) · VAPA antibodies (2) · Zonula occludens protein 3 antibodies (3) ...
http://www.abcam.com/index.html?c=2105...

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