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AIM2


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Gene DB Home
Symbol:AIM2
Name(s):absent in melanoma 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:PYHIN4
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17726700 inactivation of AIM2 by genetic and epigenetic mechanisms is frequent in Mismatch repair -deficient colorectal cancers, thus suggesting that AIM2 is a mutational target relevant for the progression of MSI-H colorectal cancers.
16432157 AIM2 associates with tumor suppression activity
15582594 AIM2 could homodimerise via the amino-terminal (PAAD/DAPIN) region and heterodimerise with the related IFI 16 protein
15076139 AIM-2 antigen is expressed in glioblastoma multiforme (GBM) in primary cultured cells and established GBM cell lines

Recent Publications on AIM2:

Pubmed Logo
Coding microsatellite instability analysis in microsatellite unstable small intestinal adenocarcinomas identifies MARCKS as a common target of inactivation.
Approximately 15% of small intestinal adenocarcinomas show inactivation of...
24th October, 2009
Department of Applied Tumor Biology, Institute of Pathology, University of Mol Carcinog. 2009 Oct 22.
DOI Direct Link
Intracellular detection and immune signaling pathways of DNA vaccines.
Parallel to attenuated and subunit vaccines, DNA vaccines require adjuvant...
23rd October, 2009
Bio-organic and Medicinal Chemistry, Centre of Immunology, Burnet Expert Rev Vaccines. 2009 Sep;8(9):1161-70.
DOI Direct Link
Cytoplasmic nucleic acid sensors in antiviral immunity.
The innate immune system uses pattern recognition receptors (PRRs) to...
21st October, 2009
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Trends Mol Med. 2009 Aug;15(8):359-68. Epub 2009 Aug 6.
DOI Direct Link
Restoration of Absent in Melanoma 2 (AIM2) induces G2/M cell cycle arrest and promotes invasion of colorectal cancer cells.
Absent in melanoma 2 (AIM2) is a member of the interferon-inducible...
2nd October, 2009
Dept. of Applied Tumor Biology, Institute of Pathology, University Int J Cancer. 2009 Sep 30.
DOI Direct Link
Expression profile of HIN200 in leukocytes and renal biopsy of SLE patients by real-time RT-PCR.
HIN200 is a human IFN-inducible gene and homologous to murine IFI202 gene,...
19th September, 2009
Medical Microbiology Interdisciplinary Program, Graduate School, Lupus. 2009 Oct;18(12):1066-72.
DOI Direct Link

View more research publications.

Clinical Trials:

Clinical Trials Logo
Gas Supply, Demand and Middle Ear Gas Balance: Specific Aim 2

Patents:

Patents logo
US Patent No.Title
7598080 Diagnostic assay for source of inflammation
5539739 Asynchronous interface between parallel processor nodes
5640360 Address buffer of semiconductor memory device
6470366 Angle calculation circuit
6479254 Apoptosis inducing molecule II

View more patents.

AIM2 results (if any) from reagent suppliers

Google CSE Logo
AIM2 antibody (ab76423) | Abcam
Rabbit polyclonal to AIM2. AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell ...
http://www.abcam.com/AIM2-antibody-ab76423.html...

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AIM2 siRNA (h) sc-88166
Click here for details. suitable control antibody: contact Technical Service for availability of control antibody; sqRT-PCR Primer also available: AIM2 ...
http://www.scbt.com/ja/datasheet-88166-aim2-sirna-h.html...

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AIM2 antibodies: Cancer > Oncoproteins/suppressors > Tumor ...
AIM2 antibodies. ... Image Abreview Publication. ab76423 · AIM2 antibody. WB, ELISA. Images. Rabbit polyclonal. Reacts with: ...
http://www.abcam.com/index.html?t=243129&pt=1&c=4340&ei=&mu=...

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AIM Antibody / AIM Antibodies
Lentiviral Particles: sc-88166-V. AIM2 siRNA (m): sc-140968. AIM2 shRNA Plasmid (m): sc-140968-SH. AIM2 shRNA (m) Lentiviral Particles: sc-140968-V ...
http://www.scbt.com/table-aim.html...

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Aurora B Antibody Bethyl Laboratories
... Aurora-and lpl1-like midbody-associated protein 1, AIM-1, Aurora/IPL1- related kinase 2, Aurora-related kinase 2, STK-1, AURKB, AIK2, AIM2, ARK2, ...
http://www.bethyl.com/go/?product/A300-431A...

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All Oncoproteins/suppressors | Abcam
AIM2 antibody. WB, ELISA. Images. Rabbit polyclonal. Reacts with: Hu. ab56149 · ALDH1L1 antibody. WB, ELISA. Rabbit polyclonal. Reacts with: Hu, Ms, Rat ...
http://www.abcam.com/index.html?c=4192...

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Citations Search
(2006) AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol. Cancer Ther. 5 , 1-7 . ...
http://www.promega.com/citations/default.aspx?citapp=BRCARef...

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