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HAND2


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Symbol:HAND2
Name(s):heart and neural crest derivatives expressed 2
Type:protein-coding
Organism:Homo sapiens
Synonyms:DHAND2, FLJ16260, Hed, MGC125303, MGC125304, Thing2, dHand
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
16467358 demonstrate evolutionarily conserved functions of HAND transcription factors in Drosophila and mammalian cardiogenesis, and reveal a previously unrecognized requirement of Hand genes in hematopoiesis
15351717 dHAND/E-protein (E2A, ME2, and ALF1) heterodimers have distinct DNA binding specificities
12858532 effects of gene mutations on ventricular development
16280598 These results demonstrate the direct interactions of the Phox2a and b and dHAND transcription factors within a noradrenergic cell type

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDpaired-like homeobox 2abasic helix-loop-helix transcription factor HAND2--Pubmed
HPRDpaired-like homeobox 2abasic helix-loop-helix transcription factor HAND2--Pubmed
HPRDCentromeric protein bbasic helix-loop-helix transcription factor HAND2--Pubmed
HPRDcentromere protein BHAND2--Pubmed
HPRDE1A binding protein p300basic helix-loop-helix transcription factor HAND2--Pubmed
HPRDE1A binding protein p300HAND2--Pubmed
HPRDGATA binding protein 4basic helix-loop-helix transcription factor HAND2--Pubmed
HPRDNucleophosmin 1basic helix-loop-helix transcription factor HAND2--Pubmed
HPRDnucleophosmin 1 isoform 1HAND2--Pubmed
HPRDdelta isoform of regulatory subunit B56, protein phosphatase 2A isoform 1HAND2--Pubmed

Recent Publications on HAND2:

Pubmed Logo
4q32-q35 and 6q16-q22 are valuable candidate regions for split hand/foot malformation.
On the basis of the Human Cytogenetic Database, a computerized catalog of...
9th October, 2009
Institute of Medical Genetics, University of Zurich, Schwerzenbach, Eur J Hum Genet. 2009 Aug;17(8):1086-91. Epub 2009 Feb 18.
DOI Direct Link
Pbx acts with Hand2 in early myocardial differentiation.
Transcription factors of the basic helix-loop-helix (bHLH) family are...
1st October, 2009
Division of Human Biology, Fred Hutchinson Cancer Research Center, Dev Biol. 2009 Sep 15;333(2):409-18. Epub 2009 Jul 14.
DOI Direct Link
The bHLH transcription factor Hand2 regulates the expression of nanog in ANS differentiation.
The basic helix-loop-helix transcription factor Hand2 is induced by bone...
30th September, 2009
Laboratory of Genome Biology, Department of Biological Science and Biochem Biophys Res Commun. 2009 Dec 11;390(2):223-9. Epub 2009 Sep 26.
DOI Direct Link
Clonal Differentiation of Skeletal Muscle-Derived CD34-/45- Stem Cells into Cardiomyocytes in vivo.
The differentiation and/or therapeutic potential of skeletal...
29th July, 2009
Tokai University School of Medicine, Regenerative Medicine, 143 Stem Cells Dev. 2009 Jul 27.
DOI Direct Link
Labeled microRNA pull-down assay system: an experimental approach for high-throughput identification of microRNA-target mRNAs.
We developed a simple, direct and cost-effective approach to search for...
2nd July, 2009
Institute of Molecular and Cellular Biology, National Taiwan University, Nucleic Acids Res. 2009 Jun;37(10):e77. Epub 2009 May 6.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7601532 Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma
7384045 Method for providing a blackjack double down wager
7250496 Bioinformatically detectable group of novel regulatory genes and uses thereof
6572470 Apparatus and method for playing a card game
5551010 Arithmetic operation unit and memory accessing device for accessing primary and secondary cache memories independently of a CPU

View more patents.

HAND2 results (if any) from reagent suppliers

Google CSE Logo
HAND2 antibodies: Cardiovascular > Heart > Cardiogenesis ...
HAND2 antibodies. ... HAND2 antibody - Carboxyterminal end. IHC-P, ELISA. Images . Rabbit polyclonal. Reacts with: Hu. Terms and conditions · Legal ...
http://www.abcam.com/index.html?t=55717&pt=1&c=4445&ei=&mu=r...

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ORDERING INFORMATION
26 Feb 2007 ... HAND2 is essential for cardiac morphogenesis and required for ... HAND2 is also implicated in limb development acting as an ...
http://www.rndsystems.com/pdf/AF3876.pdf...

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Abgent - Transcription and Regulation Antibodies ...
AP6117a, HAND2 Antibody (C-term), WB, IHC, E, H. AT2314aNEW, HAND2 monoclonal antibody (M05), ELISA,WB-Re,WB-Tr, H. AT2315aNEW, HAND2 monoclonal antibody ...
http://www.abgent.com/products/category/nuclear_signaling/tr...

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Search for Products - R&D Systems
Molecule: HAND2. You are viewing records 1-2 out of 2 total records on 1 page Pages: ... HAND2, Human/Mouse HAND2 Affinity Purified Polyclonal Ab, Goat IgG
...
http://www.rndsystems.com/product_results.aspx?m=3381&c=0...

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Genetic Disease Markers
Heart and neural crest derivatives expressed 2 (HAND2) polyclonal antibody, PAB- 10481, $175.00. Kallmann syndrome 1 (KAL1) polyclonal antibody, PAB-10758 ...
http://www.orbigen.com/dictionary/cat1052.htm...

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Antibody Products - IgG Polyclonal Antibodies - GenWay
hand2; dhand - Heart and neural crest derivatives expressed transcript 2 [Danio rerio]; N/A, IgG Polyclonal E, Source: Goat Reactivity: Zebrafish ...
http://www.genwaybio.com/all_polyclonal_antibodies.php?fl=H...

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Paired-like Homeobox 2a (Gene PHOX2A)
Hand2 plays a major role in the induction of the noradrenalin phenotype, Morikawa Y, ... (2007) Hand2 determines the noradrenergic phenotype in the mouse
...
http://www.sigmaaldrich.com/life-science/your-favorite-gene-...

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