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MAGED1


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Symbol:MAGED1
Name(s):melanoma antigen family D, 1
Type:protein-coding
Organism:Homo sapiens
Synonyms:DLXIN-1, NRAGE
Links: Pubmed, Entrez Gene, GeneCards, BioGPS, Map Viewer.

Gene Information from Publications

Publication Link Summary of findings
17453828 These findings provide new insight into the ability of MAGE-D1 to suppress the motility and adhesion response of tumor cells by interfering with actin cytoskeleton reorganization and hypoxia inducible factor 1-dependent gene expression.
17149546 MAGE-D1 might be a novel inhibitor of angiogenesis in vitro and in vivo.
11959851 A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1.
17140727 studies indicate for the first time that NRAGE could suppress metastasis of melanoma and pancreatic cancer probably through downregulation of MMP-2
17488777 Che-1 interacts with NRAGE and NRAGE overexpression downregulates endogenous Che-1 by targeting it for proteasome-dependent degradation.
15930293 MAGE-D1 protein expression was reduced in 6 of 16 breast carcinoma cell lines as compared with untransformed immortal mammary epithelial cell lines; suppression of MAGE-D1 expression may be involved in the tumorigenesis of some sporadic breast cancers.
15162511 The expression pattern of Maged1 roughly summarizes that of Maged2 and Maged3
16125672 demonstrate the importance of human NRAGE in homotypic cell-to-cell adhesion and illuminate the mechanism of human NRAGE in the process of inhibition of cell adhesion
15094062 hNRAGE arrests cell growth through a p53 dependent pathway. hNRAGE also increases the p53 protein level as well as its phosphorylation (Ser392).

Interacting gene products

Interaction Type Gene 1 Gene 2 Interaction description Complex Publication Link
HPRDbaculoviral IAP repeat-containing protein 4Melanoma antigen family D, 1--Pubmed
HPRDbaculoviral IAP repeat-containing protein 4Melanoma antigen family D, 1--Pubmed
HPRDdistal-less homeobox 4 isoform aMelanoma antigen family D1--Pubmed
HPRDMSX2Melanoma antigen family D, 1--Pubmed
HPRDmsh homeobox 2Melanoma antigen family D1--Pubmed
HPRDROR2 receptor tyrosine kinaseMelanoma antigen family D, 1--Pubmed
HPRDreceptor tyrosine kinase-like orphan receptor 2 precursorMelanoma antigen family D1--Pubmed
HPRDMelanoma antigen family D1unnamed protein product--Pubmed
HPRDMelanoma antigen family D1praja 2, RING-H2 motif containing--Pubmed
HPRDMelanoma antigen family D, 1Melanoma antigen family D, 1--Pubmed

Recent Publications on MAGED1:

Pubmed Logo
MAGE-D1 inhibits proliferation, migration and invasion of human breast cancer cells.
MAGE-D1, also known as NRAGE or Dlxin-1, is a member of the MAGE family of...
25th September, 2009
Department of Pathology, Key Laboratory of Carcinogenesis and Oncol Rep. 2009 Sep;22(3):659-65.
NRAGE: a potential rheostat during branching morphogenesis.
Branching morphogenesis is a developmental process characteristic of many...
28th July, 2009
Maine Medical Center Research Institute, Center for Molecular Medicine, Mech Dev. 2009 May-Jun;126(5-6):337-49. Epub 2009 Mar 4.
DOI Direct Link
An integrated approach of differential mass spectrometry and gene ontology analysis identified novel proteins regulating neuronal differentiation and survival.
MS-based quantitative proteomics is widely used for large scale...
16th June, 2009
Department of Tumor Genetics and Biology, Graduate School of Medical Mol Cell Proteomics. 2009 Oct;8(10):2350-67. Epub 2009 Jun 13.
DOI Direct Link
[Construction of recombinant adenovirus vector of hNRAGE gene and its effect on cell cycle of 293 cells]
AIM: To construct the recombinant adenovirus vector of hNRAGE gene and...
25th April, 2009
Jiangsu Key Laboratory for Molecular and Medical Biotechnology, Nanjing Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2006 Jan;22(1):18-21.
NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo.
NRAGE (also known as Maged1, Dlxin) is a member of the MAGE gene family...
29th January, 2009
URPHYM (Unite de Recherches en Physiologie Moleculaire), FUNDP School of Cell Death Differ. 2008 Dec;15(12):1921-9. Epub 2008 Sep 5.
DOI Direct Link

View more research publications.

Patents:

Patents logo
US Patent No.Title
7608395 Systemic lupus erythematosus diagnostic assay
7547687 Therapeutic treatment methods
7501281 Compositions, methods and kits related to thrombin, Notch signaling and stamatogenesis and growth of stem cells
7482334 Therapeutic treatment methods

MAGED1 results (if any) from reagent suppliers

Google CSE Logo
MAGED1 antibodies: Cell Biology > Apoptosis > Intracellular ...
MAGED1 antibodies. ... MAGED1 antibody. IP, ICC, WB. Rabbit polyclonal. Reacts with: Hu, Ms, Rat. ab77045 · MAGED1 antibody. WB, I-ELISA, sELISA ...
http://www.abcam.com/index.html?t=162921&pt=1&c=298&ei=&mu=r...

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Melanoma antigen family D 1 (MAGED1) polyclonal antibody - Orbigen ...
KLH conjugated synthetic peptide comprised of amino acids 441 - 456 [ NLRPSPNLRPSPNSRA] of the human melanoma antigen family D 1 (MAGED1) protein. ...
http://www.orbigen.com/commerce/catalog/product.jsp?product_...

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NRAGE (H-300) Antibody sc-28243
Human, MAGED1, 9500, Xp11.22, NM_001005332, NM_001005333, NM_006986 · Q9Y5V3 · 300224. Mouse, Maged1, 94275, X C3, Q9QYH6 ...
http://www.scbt.com/datasheet-28243-nrage-h-300-antibody.htm...

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Oncoproteins
Melanoma antigen family C 1 (MAGEC1) polyclonal antibody, PAB-10803, $175.00. Melanoma antigen family D 1 (MAGED1) polyclonal antibody, PAB-10804, $175.00 ...
http://www.orbigen.com/dictionary/cat1054.htm...

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NRAGE (C-20) Antibody sc-14400
Species, Gene Name, Gene ID, Chromosome Location, Isoform (mRNA) Accession #, Protein Accession #, OMIM™ Number. Human, MAGED1, 9500, Xp11.22, NM_001005332,
...
http://www.scbt.com/datasheet-14400-nrage-c-20-antibody.html...

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Oncoproteins - Orbigen Inc. - Orbigen Inc.
PAB-10804, Melanoma antigen family D 1 (MAGED1) polyclonal antibody · NM_006986, 100 µg, $210.00. PAB-10805, Melanoma antigen family D 2 (MAGED2) polyclonal ...
http://www.orbigen.com/commerce/catalog/spcategory.jsp?categ...

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Abgent - Neurosciences Antibodies
AP1467c, Latexin Antibody (Center), WB, IHC, E, H. AP1467a, Latexin Antibody (N- term), WB, E, H. AP6176a, MAGED1 Antibody (Center), WB, IHC, E, H ...
http://www.abgent.com/products/category/neurosciences...

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